Project description
Empowering scientists to advance sepsis care
Sepsis, which claims 7-9 million lives annually, is a critical global issue, with intensive care units in the EU facing the brunt of its impact. The lack of timely diagnostic methods and effective treatments has perpetuated its high mortality rate. With the support of the Marie Skłodowska-Curie Actions programme, the PRAETORIAN project has pioneered a unique doctoral programme, nurturing a new generation of scientists dedicated to revolutionising sepsis care. These aspiring researchers are set to pool their talents and skills to create cutting-edge approaches in precision sepsis care. Recent findings pinpoint neutrophil activation and damage-associated patterns as key players in sepsis onset, yet translating this knowledge into practical diagnostic and therapeutic solutions has remained a challenge that PRAETORIAN hopes to help address.
Objective
Sepsis remains one of the major challenges for societies worldwide, causing an estimated 7-9 million deaths every year. It is the leading cause of death at intensive care units in the EU. This high mortality persists because at present methods for timely diagnosis are lacking and no effective therapy is available. Therefore, there is a clear and urgent medical need to provide novel diagnostics and therapeutics for use in sepsis. The PRAETORIAN Doctoral Network has created a doctorate programme to deliver innovative training on preclinical and clinical science, business- and entrepreneurial aspects, intellectual properties and more, covering multiple aspects of the drug discovery and development process. This programme is unique as it will deliver a new generation of young scientists, each Doctoral Candidates (DCs), who will collaboratively work to develop novel approaches in precision sepsis patient care providing new diagnostics and therapeutics to answer to an urgent unmet clinical need. Recent insights have indicated a pivotal role for neutrophil activation and so-called damage associated patterns in the initiation and propagation of sepsis. However a comprehensive view on how these processes cause the onset of sepsis remains elusive and there is an urgent need to translate experimental findings into adequate diagnostic and therapeutic solutions. PRAETORIAN was designed to address this urgent need by bringing together specialists from academia and industry to shape a new generation of entrepreneurial scientists who have skills, expertise and knowhow to further our understanding of sepsis pathophysiology into tangible and effective solutions for novel diagnosis and therapy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- social sciencessociologydemographymortality
- medical and health sciencesbasic medicinephysiologypathophysiology
- medical and health sciencesclinical medicinecritical care medicine
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Keywords
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral NetworksCoordinator
6200 MD Maastricht
Netherlands