Single-nuclei UPR profiling by flow cytometry reveals bortezomib resistance mechanisms in multiple myeloma
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Author(s):
Julien P Gigan, Paulina Garcia-Gonzalez, Angelo Pilotti, Lou Galliot, Alexandre Reynaud, Yoan Ghaffar, Felipe Flores-Santibáñez, Sara Ghafoori, Eve Seillier, Rosario Lavignolle-Heguy, Daniela Barros, Caroline Bret, Sharon Fichaux, Alexis Combes, Alessandro Bani, Rejane Rua, Evelina Gatti, Béatrice Nal-Rogier, Stéphane Rocchi, Jérôme Moreaux, Philippe Pierre, Rafael J Argüello
Published in:
EMBO Molecular Medicine, Issue 18, 2026, ISSN 1757-4684
Publisher:
Springer Science and Business Media LLC
DOI:
10.1038/S44321-026-00469-7
Induction of the ISR by AB5 subtilase cytotoxin drives type-I IFN expression in pDCs via STING activation
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Author(s):
Daniela Barros, Beatriz H. Ferreira, Paulina Garcia-Gonzalez, Francesco Carbone, Marine Luka, Fátima Leite-Pinheiro, Mariana D. Machado, Theopisti Nikolaou, Angelo Pilotti, Eliot Goguet, Paulo Antas, Andreia Mendes, Lichen Zhang, Marina Cresci, Lou Galliot, Julien P. Gigan, Marisa Reverendo, Bing Su, Miwako Narita, Adrienne W. Paton, James C. Paton, Stéphane Rocchi, Frédéric Rieux-Laucat, Rafael J. Argüello, Béatrice Nal, Yinming Liang, Mickaël Ménager, Evelina Gatti, Catarina R. Almeida, Philippe Pierre
Published in:
Proceedings of the National Academy of Sciences, Issue 122, 2025, ISSN 0027-8424
Publisher:
Proceedings of the National Academy of Sciences
DOI:
10.1073/PNAS.2421258122
