Project description
A new chapter for applied chemistry and materials science
Darwinian evolution, described as a remarkable force shaping life, has been a cornerstone for human advancements in agriculture and biotechnology. However, its application has been confined to biological and computational realms, leaving vast untapped potential. The challenge has been extending its creative prowess beyond living organisms. With the support of Marie Skłodowska-Curie Actions, the DarChemDN project aims to create synthetic chemical systems capable of undergoing open-ended Darwinian evolution. This collaborative effort by 10 doctoral candidates marks a pioneering leap into uncharted territory, promising profound implications for applied chemistry and materials science. The project involves developing autocatalytic systems, integrating them into compartments, and enhancing evolvability through metabolism.
Objective
Darwinian evolution is unrivalled in its ability to invent, which Humankind has already exploited for various purposes such as plant and animal breeding and directed evolution of proteins. In these examples, evolution acts on living species or material derived from them, but so far it has not been possible to apply Darwinian evolution outside the realm of biological and some computational systems. The aim of the DarChemDN research programme is to develop Darwinian Chemistry by creating, for the first time, synthetic chemical systems that can reproduce and undergo open-ended Darwinian evolution.
Our pioneering concept will be implemented in a joint effort by 10 doctoral candidates (DCs) working on (1) the identification and development of viable autocatalytic systems, (2) incorporating these systems into compartments (emulsions and coacervates) to couple autocatalysis to compartment growth and division and (3) integrating metabolism in the new systems, to (4) enhance evolvability and achieve Darwinian evolution.
We have assembled a consortium of scientific excellence that brings together multiple ERC grant holders, supervisors of several previous MSCA-ITNs and highly innovative companies with complementary expertise to deliver this unique research and training programme. Exploiting the full potential of the envisioned scientific breakthroughs requires a structured training programme to equip the first generation of Darwinian Chemists with advanced scientific, business, and transferable skills. In the long-term, we envision that the DarChemDN DCs will unleash the power of Darwinian evolution to have a profound impact on applied chemistry and materials science in areas ranging from catalysis to sensing and signalling by allowing optimisation of functions through evolution.
Fields of science
Keywords
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral NetworksCoordinator
9712CP Groningen
Netherlands