Ion channels in erythrocytes: A novel understanding from regulation of erythropoiesis and physiological function to diagnostic measures and therapeutic concepts

Informations projet

INNOVATION

N° de convention de subvention: 101120168

DOI

10.3030/101120168

Date de signature de la CE 11 Juillet 2023

Date de début 1 Septembre 2023

Date de fin 31 Août 2027

Financé au titre de

• Marie Skłodowska-Curie Actions (MSCA)

Coût total

Aucune donnée

Contribution de l’UE

€ 2 690 092,80

Coordonné par

UNIVERSITAT DES SAARLANDES
Germany

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Data Management Plan (1)

Data management plan

Entire handling structure and instruction for all data collected or generated in INNOVATION

Documents, reports (7)

Functional role of ion channels in mature genetically modified and wild-type cRBC

Typical indices for healthy RBCs will be measured in RBCs with or without ion channel mutations.

A diagnostic algorithm for channelopathies developed on CBC automated analysers

Prediction of putative channelopathies among other haematological disorders

Imaging software identifying fused RBC

Complementary microscopic visual and statistical proof of what is otherwise measured from the more global diffraction pattern

Selection of channelrhodopsins

Report about evaluation based on literature research

RBC micro-thrombi test protocol (M24)

Combining developed ion channel manipulation D4.3, RBC-disorders, thromboelastography and other methods to measure clot formation/retraction

Validation of new osmoscan parameters

Channel function related to new ektacytometry biomarkers

Project website

The website will inform the public about the project’s aims, updates and results. The website will be continuously updated throughout the project’s lifetime. Links to social media will be implemented as well

Publications

Peer reviewed articles (2)

Not-So-Rare Defects of RBC Lipidic Composition: Four New Cases of Flippase Deficiency Due to ATP11C Mutations

Auteurs: Elisa Fermo, Elena Trombetta, Anna Paola Marcello, Cristina Vercellati, Giulia Maria Ferrari, Anna Zaninoni, Valentina Brancaleoni, Elena Di Pierro, Sara Beneventi, Marta Tornese, Bruno Fattizzo, Tommaso Casini, Paola Corti, Paola Bianchi
Publié dans: International Journal of Molecular Sciences, Numéro 26, 2025, ISSN 1422-0067
Éditeur: MDPI AG
DOI: 10.3390/IJMS26167722

Not so Rare, Not so Mild Disease: Defects of Flippase Activity Due to ATP11C Mutations. Description of Three New Cases

Auteurs: Elisa Fermo, Elena Trombetta, Anna Marcello, Cristina Vercellati, Giulia Maria Ferrari, Anna Zaninoni, Valentina Brancaleoni, Marta Tornese, Wilma Barcellini, Tommaso Casini, Paola Consuelo Corti, Paola Bianchi
Publié dans: Blood, Numéro 144, 2024, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/BLOOD-2024-204922

Other (1)

Sodium-Selective Channelrhodopsins

Auteurs: Ariel Coli; Shiqiang Gao; Lars Kaestner
Publié dans: Cells, 2024
DOI: 10.22028/D291-43572