MICROBOTS – Unravel the power of MICRObial metaBOliTeS to prevent graft versus host disease and cure leukemia relapse

Project Information

MICROBOTS

Grant agreement ID: 101124680

DOI

10.3030/101124680

EC signature date 9 February 2024

Start date 1 June 2024

End date 31 May 2029

Funded under

• European Research Council (ERC)

Total cost

€ 1 999 901,00

EU contribution

€ 1 999 901,00

Coordinated by

KLINIKUM DER UNIVERSITAET REGENSBURG
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (4)

Tissue-adapted Tregs harness inflammatory signals to promote intestinal repair from therapy-related injury

Author(s): Julius C. Fischer, Sascha Göttert, Maximilian Giller, Paul Heinrich, Kaiji Fan, Omer Khalid, Caroline N. Walther, Maria Drießlein, Sophie M. Nefzger, Gabriel Eisenkolb, Vincent R. Timnik, Sebastian Jarosch, Lena Klostermeier, Thomas Engleitner, Nicholas Strieder, Claudia Gebhard, Sarah Diederich, Nicole A. Schmid, Laura Lansink Rotgerink, Laura Joachim, Sakhila Ghimire, Eva Vonbrunn, Maike Büttner-Herold, Marianne Remke, Katja Steiger, Rupert Öllinger, Roland Rad, Daniel Wolff, Markus Feuerer, Petra Hoffmann, Matthias Edinger, Michael Rehli, Markus Tschurtschenthaler, Oliver Kepp, Guido Kroemer, Erik Thiele Orberg, Stephanie E. Combs, Wolfgang Herr, Florian Bassermann, Dirk H. Busch, Ernst Holler, Simon Heidegger, Hendrik Poeck
Published in: Signal Transduction and Targeted Therapy, Issue 10, 2025, ISSN 2059-3635
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41392-025-02476-5

The microbial metabolite desaminotyrosine protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration

Author(s): Sascha Göttert, Erik Thiele Orberg, Kaiji Fan, Paul Heinrich, Diana M. Matthe, Omer Khalid, Lena Klostermeier, Chiara Suriano, Nicholas Strieder, Claudia Gebhard, Eva Vonbrunn, Andreas Mamilos, Daniela Hirsch, Elisabeth Meedt, Karin Kleigrewe, Andreas Hiergeist, Alix Schwarz, Joachim Gläsner, Sakhila Ghimire, Laura Joachim, Florian Voll, Klaus Neuhaus, Klaus-Peter Janssen, Markus Perl, Franziska Pielmeier, Jürgen Ruland, Marina Kreutz, Daniela Weber, Christian Schmidl, Natalie Köhler, Markus Tschurtschenthaler, Petra Hoffmann, Matthias Edinger, Daniel Wolff, Florian Bassermann, Michael Rehli, Dirk Haller, Matthias Evert, Kai Hildner, Maike Büttner-Herold, Wolfgang Herr, André Gessner, Simon Heidegger, Ernst Holler, Hendrik Poeck
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-65180-6

Microbiome, GvHD, and immune reconstitution in allogeneic hematopoietic cell transplantation

Author(s): Daniela Weber, Misbah Tariq, Mette Hazenberg, Hendrik Poeck, Florent Malard
Published in: Bone Marrow Transplantation, Issue 61, 2026, ISSN 0268-3369
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41409-026-02798-0

Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantation

Author(s): Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Paul Heinrich, Jinlong Ru, Sakhila Ghimire, Oriana Miltiadous, Sarah Lindner, Melanie Tiefgraber, Sophia Göldel, Tina Eismann, Alix Schwarz, Sascha Göttert, Sebastian Jarosch, Katja Steiger, Christian Schulz, Michael Gigl, Julius C. Fischer, Klaus-Peter Janssen, Michael Quante, Simon Heidegger, Peter Herhaus, Mareike Verbeek, Jürgen Ruland, Marcel R. M. van den Brink, Daniela Weber, Matthias Edinger, Daniel Wolff, Dirk H. Busch, Karin Kleigrewe, Wolfgang Herr, Florian Bassermann, André Gessner, Li Deng, Ernst Holler, Hendrik Poeck
Published in: Nature Cancer, Issue 5, 2024, ISSN 2662-1347
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S43018-023-00669-X