MICROBOTS – Unravel the power of MICRObial metaBOliTeS to prevent graft versus host disease and cure leukemia relapse

Informazioni relative al progetto

MICROBOTS

ID dell’accordo di sovvenzione: 101124680

DOI

10.3030/101124680

Data della firma CE 9 Febbraio 2024

Data di avvio 1 Giugno 2024

Data di completamento 31 Maggio 2029

Finanziato da

• European Research Council (ERC)

Costo totale

€ 1 999 901,00

Contributo UE

€ 1 999 901,00

Coordinato da

KLINIKUM DER UNIVERSITAET REGENSBURG
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (4)

Tissue-adapted Tregs harness inflammatory signals to promote intestinal repair from therapy-related injury

Autori: Julius C. Fischer, Sascha Göttert, Maximilian Giller, Paul Heinrich, Kaiji Fan, Omer Khalid, Caroline N. Walther, Maria Drießlein, Sophie M. Nefzger, Gabriel Eisenkolb, Vincent R. Timnik, Sebastian Jarosch, Lena Klostermeier, Thomas Engleitner, Nicholas Strieder, Claudia Gebhard, Sarah Diederich, Nicole A. Schmid, Laura Lansink Rotgerink, Laura Joachim, Sakhila Ghimire, Eva Vonbrunn, Maike Büttner-Herold, Marianne Remke, Katja Steiger, Rupert Öllinger, Roland Rad, Daniel Wolff, Markus Feuerer, Petra Hoffmann, Matthias Edinger, Michael Rehli, Markus Tschurtschenthaler, Oliver Kepp, Guido Kroemer, Erik Thiele Orberg, Stephanie E. Combs, Wolfgang Herr, Florian Bassermann, Dirk H. Busch, Ernst Holler, Simon Heidegger, Hendrik Poeck
Pubblicato in: Signal Transduction and Targeted Therapy, Numero 10, 2025, ISSN 2059-3635
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41392-025-02476-5

The microbial metabolite desaminotyrosine protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration

Autori: Sascha Göttert, Erik Thiele Orberg, Kaiji Fan, Paul Heinrich, Diana M. Matthe, Omer Khalid, Lena Klostermeier, Chiara Suriano, Nicholas Strieder, Claudia Gebhard, Eva Vonbrunn, Andreas Mamilos, Daniela Hirsch, Elisabeth Meedt, Karin Kleigrewe, Andreas Hiergeist, Alix Schwarz, Joachim Gläsner, Sakhila Ghimire, Laura Joachim, Florian Voll, Klaus Neuhaus, Klaus-Peter Janssen, Markus Perl, Franziska Pielmeier, Jürgen Ruland, Marina Kreutz, Daniela Weber, Christian Schmidl, Natalie Köhler, Markus Tschurtschenthaler, Petra Hoffmann, Matthias Edinger, Daniel Wolff, Florian Bassermann, Michael Rehli, Dirk Haller, Matthias Evert, Kai Hildner, Maike Büttner-Herold, Wolfgang Herr, André Gessner, Simon Heidegger, Ernst Holler, Hendrik Poeck
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-65180-6

Microbiome, GvHD, and immune reconstitution in allogeneic hematopoietic cell transplantation

Autori: Daniela Weber, Misbah Tariq, Mette Hazenberg, Hendrik Poeck, Florent Malard
Pubblicato in: Bone Marrow Transplantation, Numero 61, 2026, ISSN 0268-3369
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41409-026-02798-0

Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantation

Autori: Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Paul Heinrich, Jinlong Ru, Sakhila Ghimire, Oriana Miltiadous, Sarah Lindner, Melanie Tiefgraber, Sophia Göldel, Tina Eismann, Alix Schwarz, Sascha Göttert, Sebastian Jarosch, Katja Steiger, Christian Schulz, Michael Gigl, Julius C. Fischer, Klaus-Peter Janssen, Michael Quante, Simon Heidegger, Peter Herhaus, Mareike Verbeek, Jürgen Ruland, Marcel R. M. van den Brink, Daniela Weber, Matthias Edinger, Daniel Wolff, Dirk H. Busch, Karin Kleigrewe, Wolfgang Herr, Florian Bassermann, André Gessner, Li Deng, Ernst Holler, Hendrik Poeck
Pubblicato in: Nature Cancer, Numero 5, 2024, ISSN 2662-1347
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S43018-023-00669-X