Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques
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Autores:
Katyayani Sukhavasi, Giuseppe Mocci, Lijiang Ma, Chani J. Hodonsky, Ernest Diez Benevante, Lars Muhl, Jianping Liu, Sonja Gustafsson, Byambajav Buyandelger, Simon Koplev, Urban Lendahl, Michael Vanlandewijck, Prosanta Singha, Tiit Örd, Mustafa Beter, Ilakya Selvarajan, Johanna P. Laakkonen, Marika Väli, Hester M. den Ruijter, Mete Civelek, Ke Hao, Arno Ruusalepp, Christer Betsholtz, Heli Järve, Jason C. Kovacic, Clint L. Miller, Casey Romanoski, Minna U. Kaikkonen, Johan L. M. Björkegren
Publicado en:
Nature Cardiovascular Research, Edición 4, 2025, ISSN 2731-0590
Editor:
Springer Science and Business Media LLC
DOI:
10.1038/S44161-025-00628-Y
Decreased degree of adipocyte differentiation in visceral adipose tissue contributes to metabolic dysfunction-associated steatotic liver disease
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Autores:
Kyla Z. Gelev, Seung Hyuk T. Lee, Marcus Alvarez, Rosellina M. Mancina, Federica Tavaglione, Oveis Jamialahmadi, Umberto Vespasiani-Gentilucci, Asha Kar, Zitian Wang, Dorota Kaminska, Minna U. Kaikkonen, Ville Männistö, Sini Heinonen, Tuure Saarinen, Anne Juuti, Kirsi H. Pietiläinen, Jussi Pihlajamäki, Stefano Romeo, Päivi Pajukanta
Publicado en:
Nature Communications, Edición 17, 2026, ISSN 2041-1723
Editor:
Springer Science and Business Media LLC
DOI:
10.1038/S41467-026-73660-6
Adipose single cell epigenome and transcriptome localize genetic risk for cardiometabolic disease and accelerated aging
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Autores:
Seung Hyuk T. Lee, Asha Kar, Kyla Z. Gelev, Zeyuan Johnson Chen, Sankha Subhra Das, Sini Heinonen, Tuure Saarinen, Maija Vaittinen, Dorota Kaminska, Hilkka Peltoniemi, Chongyuan Luo, Anne Juuti, Ville Männistö, Jussi Pihlajamäki, Minna U. Kaikkonen, Kirsi H. Pietiläinen, Brunilda Balliu, Päivi Pajukanta
Publicado en:
Nature Communications, Edición 17, 2026, ISSN 2041-1723
Editor:
Springer Science and Business Media LLC
DOI:
10.1038/S41467-026-72248-4
Female-Biased VSMC GRNs Predict MYH9 as Regulator of Fibrous Plaque Phenotype
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Autores:
R. Noah Perry, Graham Lenert, Ernest Diez Benavente, Aydin Bölük, Rebecca Hernandez, Lijiang Ma, Nicolas Barbera, Kelsey Watts, Victor D. Mendoza, Tiit Örd, Mari Taipale, Nadja Sachs, Jessica Pauli, Michal Mokry, Dominique P.V. de Kleijn, Menno P.J. de Winther, Manuel Mayr, Lars Maegdefessel, Karen Reue, Minna U. Kaikkonen, Johan L.M. Björkegren, Hester M. den Ruijter, Mete Civelek
Publicado en:
Circulation Research, Edición 138, 2026, ISSN 0009-7330
Editor:
Ovid Technologies (Wolters Kluwer Health)
DOI:
10.1161/CIRCRESAHA.125.326941
