Objective
An intricate network of blood vessels perfuses the brain to support neural cells and carry signaling molecules from the periphery. It is mainly considered a rigid “transportation network” rather than a dynamic and plastic “information network” integrated to neurons and glia. This proposal revisits this concept and aims to define the nature of vascular remodeling in healthy brains (i) and which remodeling mechanisms play a role in shaping plastic neuronal functions (ii)
The project VIRGINS explores this in the context of the neurophysiological adaptations occurring during and after pregnancy. There, sexual hormones promote neuronal plasticity, which tunes the cerebral control of energy balance, and drives the emergence of parental behaviors.
Using our unbiased whole-brain vascular mapping technique TubeMap, we found that in pregnant mouse brains, vascular territories of regions controlling energy homeostasis and hormonal states are remodeled: the Arcuate, PeriVentricular, ParaVentricular, and DorsoMedial nuclei of the Hypothalamus. We also found remodeling of blood vessels in brain regions processing pup calls: the auditory and prefrontal cortex, the hippocampus, and subcortical relays. The regional specificity of this vascular plasticity suggests precise and complex regulatory mechanisms and a role in shaping neuronal functions in the pregnant state.
To link structural, functional, and molecular changes in the neurovascular unit during gestation, we will use light sheet brain mapping, neurovascular (fast ultrasounds), and 2-photon imaging with transcriptomics, molecular and behavioral tools to determine 1) the nature of whole brain vascular plasticity during pregnancy, 2) its mechanisms and impact on the control of energy homeostasis and 3) its role in the tuning of the auditory system to infant calls. This project will transform our view on the capacity of the NeuroVascular Unit to sculpt neuronal computation and behaviors.
Fields of science
Keywords
Programme(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Funding Scheme
HORIZON-ERC - HORIZON ERC GrantsHost institution
75654 Paris
France