Project description
Bat teeth to understand mammalian tooth classes’ origin
Advancements across various disciplines have revealed fundamental principles governing the development of new physical features in evolutionary biology. However, there remains a need to comprehend the precise mechanisms through which traits originate from ancestral genomic and developmental programmes and subsequently diversify in new ecological contexts. The ERC-funded NOVELTEETH project uses bat teeth as a model to investigate the origin and diversification of mammalian tooth classes, a significant evolutionary innovation in mammals. The research entails identifying variations in tooth class morphologies and analysing developmental transcriptomic signatures to elucidate underlying genomic and developmental programmes. Additionally, the project aims to develop an integrative data-driven model of tooth class evolution using machine learning techniques and extend these models to other mammalian species.
Objective
One long-standing question in evolutionary biology is: how do new morphological innovations arise? Integrative advances in palaeontology, genomics, development and evolution have unveiled general principles behind evolutionary novelties. However, we are far from understanding the mechanisms by which novelties emerge from ancestral genomic and developmental programs and then diversify in new ecological contexts. To solve this problem, my research uses the dramatic morphological and ecological diversity of bat teeth as a model system to study the origin and diversification of a major mammalian innovation, the tooth classes. Using morphological, genomic, developmental and modelling approaches on multiple species of bats from various ecological contexts, my goal is to understand the origin of mammalian tooth classes and establish a predictive model to study their evolution. Using geometric morphometric approaches, I will first characterize the differences and unique traits in tooth class morphologies in adults and during ontogeny on CT scans (Aim 1). Then, to link the morphological variation with the underlying changes in the genomic and developmental program, I will establish a developmental transcriptomic signature for each tooth class using Spatial Transcriptomics and MERFISH in multiple species across developmental stages (Aim 2). Finally, I will link these morphological and transcriptomic changes by developing an integrative data-driven model of tooth class evolution using machine learning and extend these models to other mammals (Aim 3). By establishing bat teeth as a unique study system, my research constitutes an integrative framework using natural variation as a starting point to understand the evolution of morphological novelties in various ecological contexts.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences biological sciences zoology mammalogy
- natural sciences earth and related environmental sciences palaeontology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2023-COG
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75794 PARIS
France
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