Objective
Currently available pre-birth surgical treatments for Spina Bifida Aperta (SBA) still do not provide a complete recovery in babies and would potentially benefit from a tissue engineering approach, indeed the first clinical trial using stem cells for SBA has recently started, however this is performed via an open-uterus approach. This made me wonder, what if we can develop an innovative system to deliver via fetoscopy a bioprinted tissue engineering costructfor SBA repair? Such an approach would promote tissue regeneration and ease the surgery.
In 3D.FETOPRINT I will develop a system for the in-situ fetoscopic bioprinting of a gel composed of extracellular matrix (ECM) proteins and amniotic fluid stem cells (AFSCs) to close the defect of spina bifida aperta (SBA) in a large animal model.
The project will be divided into three work packages. First work package will address the development and testing of the gel, by studying the interaction between fetal ECM proteins and AFSCs, to define a gel formulation that could be bioprinted in-utero. Second work package will focus on the design and development of an innovative fetoscopic bioprinting device capable of bioprinting a gel patch on the fetus. Last work package will finally validate the innovative approach. We will first validate through in-vitro testing using a laparoscopic simulator, then we will perform a sheep spina bifida aperta model where the innovative fetoscopic 3D bioprinting system will be vaildated.
We will leverage my expertise in biomaterials, cells and tissue engineering device design to carry out this project that will deliver a revolutionary system that will open up the possibility to bioprint tissue engineered constructs on the fetus.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine surgery
- engineering and technology industrial biotechnology biomaterials
- medical and health sciences clinical medicine embryology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2023-COG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
20133 Milano
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.