Project description
Origami paper-based organ-on-chip devices
Funded by the European Innovation Council, the PHOENIX-OoC project aims to radically change the organ-on-chip (OoC) field by making use of paper’s versatile properties. To that end, it will develop OoC devices using a paper in origami configuration targeting cell co-cultures to better simulate different organ tissues and aiming towards (bio)sensor integration for on site/continuous monitoring of cell status/response to stimuli. The ultimate goal is to perform accurate pharmacological studies. The main idea is the introduction of a technology that can deliver a versatile set of devices with new functionalities, where it will be possible to create ready-to-use cell culture models for drug screenings in a custom-made manner.
Objective
Sustainability is one of the most important concepts nowadays, being able to drive activities in several sectors, namely environment preservation, society, and economy. In Analytical Chemistry, the development of sustainable devices was boosted by the introduction of microfluidic paper-based analytical devices (μPADs) whose advantages, however, are not only confined to the concept of sustainability. Indeed, paper as a functional material, confers unprecedented features to μPADs. However, paper-based devices remain exploited as only analytical tools, but have not (yet) been adopted by the Organ-on-Chip (OoC) world. The objective of the present project proposal is to alter this scenario. PHOENIX-OoC, we will radically change the OoC field by making use of paper’s versatile properties, and develop OoC devices using paper in origami configuration used (i) for cell co-cultures with the aim to better simulate different organ tissues, (ii) for (bio)sensors integration with the aim of on site/continuous monitoring of cells status/response to stimuli, and (iii) with the ultimate goal of performing accurate pharmacological studies. The main new idea is the introduction of a technology which can deliver a versatile set of electrochemical devices with new functionalities, in which, it will be possible to create ready-to-use cell culture models for drug screenings, in a custom-made manner. Because, OoC is a complex system with respect to μPADs, partners with different and needed skills have been gathered among the most important European scientists/entities in the field required. PHOENIX-OoC consortium brings together 6 partners, 4 Universities, 1 research organization, and 1 industrial partner (1 SME), 5 from 4 EU (associated)countries (Italy, Sweden, Spain, Serbia), and 1 non-EU member: Switzerland, which are renowned experts in the world on paper-based biosensors, in vitro/vivo studies, modelling, microfluidics, biomaterials, and joint tissue engineering.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidics
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsbiosensors
- engineering and technologyother engineering and technologiesmicrotechnologyorgan on a chip
- engineering and technologyindustrial biotechnologybiomaterials
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Programme(s)
- HORIZON.3.1 - The European Innovation Council (EIC) Main Programme
Funding Scheme
HORIZON-EIC - HORIZON EIC GrantsCoordinator
00133 Roma
Italy