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Origami Paper-based tecHnology fOr the innovativE aNd sustaInable Organ-on-Chip devices

Descripción del proyecto

Dispositivos de órgano en un chip en papel de papiroflexia

En el proyecto PHOENIX-OoC, financiado por el Consejo Europeo de Innovación, se pretende dar un vuelco al campo de los órganos en un chip (OoC, por sus siglas en inglés) aprovechando las propiedades versátiles del papel. Para ello, se desarrollarán dispositivos de OoC en papel de papiroflexia, que se emplearán en cocultivos celulares para simular mejor diferentes tejidos de órganos y para integrar (bio)sensores que supervisen de forma continua e «in situ» el estado de las células y su respuesta a estímulos. El objetivo último es efectuar estudios farmacológicos precisos. La idea principal es el desarrollo de una tecnología capaz de proporcionar un conjunto versátil de dispositivos con nuevas funcionalidades, en los que será posible crear modelos de cultivo celular listos para su uso en el cribado de fármacos personalizado.

Objetivo

Sustainability is one of the most important concepts nowadays, being able to drive activities in several sectors, namely environment preservation, society, and economy. In Analytical Chemistry, the development of sustainable devices was boosted by the introduction of microfluidic paper-based analytical devices (μPADs) whose advantages, however, are not only confined to the concept of sustainability. Indeed, paper as a functional material, confers unprecedented features to μPADs. However, paper-based devices remain exploited as only analytical tools, but have not (yet) been adopted by the Organ-on-Chip (OoC) world. The objective of the present project proposal is to alter this scenario. PHOENIX-OoC, we will radically change the OoC field by making use of paper’s versatile properties, and develop OoC devices using paper in origami configuration used (i) for cell co-cultures with the aim to better simulate different organ tissues, (ii) for (bio)sensors integration with the aim of on site/continuous monitoring of cells status/response to stimuli, and (iii) with the ultimate goal of performing accurate pharmacological studies. The main new idea is the introduction of a technology which can deliver a versatile set of electrochemical devices with new functionalities, in which, it will be possible to create ready-to-use cell culture models for drug screenings, in a custom-made manner. Because, OoC is a complex system with respect to μPADs, partners with different and needed skills have been gathered among the most important European scientists/entities in the field required. PHOENIX-OoC consortium brings together 6 partners, 4 Universities, 1 research organization, and 1 industrial partner (1 SME), 5 from 4 EU (associated)countries (Italy, Sweden, Spain, Serbia), and 1 non-EU member: Switzerland, which are renowned experts in the world on paper-based biosensors, in vitro/vivo studies, modelling, microfluidics, biomaterials, and joint tissue engineering.

Ámbito científico (EuroSciVoc)

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Régimen de financiación

HORIZON-EIC - HORIZON EIC Grants

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Convocatoria de propuestas

(se abrirá en una nueva ventana) HORIZON-EIC-2023-PATHFINDEROPEN-01

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Coordinador

UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Aportación neta de la UEn
€ 492 500,00
Coste total
€ 492 500,00

Participantes (4)

Socios (1)