Project description
Enhancing IVF with advanced embryo detection
In vitro fertilisation (IVF) is a vital option for those struggling with infertility, yet its success rate hovers around 20 %. This low rate is partly due to the challenge of selecting the most viable embryo for implantation. Currently, this selection process is both critical and imperfect, contributing to lower-than-expected outcomes. Improving embryo selection could significantly enhance IVF success. With this in mind, the EU-funded EMBRYOVOCS project will analyse the volatile organic compounds emitted by developing embryos. Researchers will use gas chromatography-mass spectrometry to identify the volatile organic compound patterns associated with successful blastocysts. These patterns will guide the creation of a portable electronic nose system, initially tested on bovine embryos and later adapted for human use, to improve embryo selection and IVF success rates.
Objective
In vitro fertilisation (IVF) has irrupted as the most important alternative for getting pregnant in a global world with decreasing natality rates. Currently, IVF success rate is around 20%. In order to improve it, the selection of the most suitable embryo for implantation is the most important factor. In the proposed project, we aim to assess embryo selection based on the analysis of the volatile organic compounds (VOCs) they emit during their development. Gas chromatography coupled to mass spectrometry (GC-MS) technique will be employed in the first step of the project for identifying the pattern of VOCs that characterise the embryos that successfully reach the blastocyst stage, as well as the blastocysts that hatch. An electronic nose system, which possesses several advantages over the GC-MS technique, such as portability, ease of use and considerably lower price, will be next developed for the selective detection of the VOC patterns identified by the GC-MS studies. Initially, the study will be performed on bovine during fellow’s placement at the Beneficiary. The electronic nose that will be developed for the bovine model will be tested on humans in a real-world environment during the additional non-academic placement of the researcher at the business partner. The results of this test will constitute the basis for the future development of a reliable device for the selection of the most suitable embryos for successful IVF outcomes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine gynaecology reproductive medicine
- medical and health sciences clinical medicine embryology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.4.1 - Widening participation and spreading excellence
MAIN PROGRAMME
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HORIZON.4.1.5 - Fostering brain circulation of researchers and excellence initiatives
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-WIDERA-2022-TALENTS-04
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
51014 Tartu
Estonia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.