Descripción del proyecto
Una prueba innovadora para detectar las fases de infección tuberculosa y la progresión de la enfermedad
La tuberculosis (TB) tiene una elevada tasa de mortalidad debido a la capacidad de la bacteria «Mycobacterium tuberculosis» (Mtb) para ocultarse tras la infección y a la falta de pruebas precisas y sensibles para detectar las distintas formas de TB y la progresión de la enfermedad. El equipo del proyecto DET-TB, financiado con fondos europeos, pretende determinar e investigar nuevos antígenos que puedan utilizarse para la detección de las fases de infección por Mtb y como herramienta de pronóstico preciso. El objetivo principal es comprender mejor los mecanismos moleculares de la infección tuberculosa e identificar los nuevos antígenos para el diseño de novedosas pruebas de ensayo de liberación de interferón γ para la detección de las diferentes fases de la infección y la progresión de la enfermedad.
Objetivo
Tuberculosis disease (TB) is the second leading infectious killer after COVID-19 (above HIV/AIDS). The main reason is due to high ability of the bacteria Mycobacterium tuberculosis (Mtb) to hide after infection and lack of the precise and sensitive tests able to detect different forms of TB and indicate disease progression. Therefore the aim of this project is to search and investigate new antigens that could be used not only for the detection of different phases of Mycobacterium tuberculosis infection but also could be used for precise prognostic tool. To achieve this goal, the experience of the applicant in a LTBI diagnostics, medical microbiology and molecular biology will be combined with hands on training in a field of bioinformatics, and in silico approaches supported by artificial intelligence computational and experimental methods applied for structural analysis of proteins supporting strategic decisions in detection system development.
As part of the World Health Organization's (WHO) End TB Strategy to reduce the mortality and incidence rates of TB by 90% and 80%, respectively, in 2025 and further reduction by 95% and 90% in 2035, reverse efforts to focus on TB infection management as one of the TB preventive care approaches for the long-term situation of TB prevention and treatment are highly needed.
The main goal of this proposal is to better understand molecular basic of the TB infection and progression aiming identification of the new antigens which later can provide a new avenue for designing of novel interferon gamma release assays (IGRA) test for detection of different phases of TB infection and predict active TB disease progression. We hypothesise that using latency associated protein candidates and IFN-γ-producing CD8+ T cells specific Mtb antigens we will be able to achieve these goals.
Ámbito científico
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- medical and health scienceshealth sciencesinfectious diseasesRNA virusesHIV
- medical and health sciencesclinical medicinepneumologytuberculosis
- medical and health scienceshealth sciencesinfectious diseasesRNA virusescoronaviruses
- natural sciencesbiological sciencesmolecular biology
Palabras clave
Programa(s)
Convocatoria de propuestas
HORIZON-WIDERA-2022-TALENTS-04
Consulte otros proyectos de esta convocatoriaRégimen de financiación
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsCoordinador
44-100 GLIWICE
Polonia