Project description
Advancing bone health for an aging population
Advancing bone health for an aging populationAgeing bones often lead to fractures and reduced mobility among the elderly. This compromises quality of life and imposes considerable social and economic burdens on healthcare systems. Traditional animal testing methods for understanding bone ageing often fail to accurately represent human-specific features. Supported by the Marie Skłodowska-Curie Actions programme, the REGENERATION project aims to create reliable and sustainable in vitro models of healthy and aged bone tissue. By establishing a research network across France, Greece, Italy, and Switzerland, REGENERATION will explore the effects of Quantum Molecular Resonance (QMR) on bone biology. This initiative will also train scientists to enhance knowledge of bone ageing, fostering personalised therapies and improving preventive care for the elderly.
Objective
REGENERATION aims to (i) build a multidisciplinary research network involving experts of technical and medical disciplines to merge their expertise and exploit possible synergies for the development of reliable and sustainable in vitro cell models of healthy and aged bone tissue treated with or without QMR (Quantum Molecular Resonance) and (ii) train a cohort of scientists and technologists in exploiting the model features to increase knowledge on the effects of aging on bone biology and mechanobiology, and on bone response to QMR, to leverage the use of cell models in clinics and basic/industrial research labs. Bone aging reduces the quality of life of the elderly and puts social and economic burden on society. Aging bones fail more easily when challenged mechanically or with toxicants or pollutants, and respond differently to drugs than healthy bone. To personalize therapies and enable better preventive care for the elderly it is essential to develop reliable and sustainable in vitro models of aged bone tissue alternative to animal tests which often fail to capture human-specific features. REGENERATION will involve 7 participants from 4 countries (Italy, France, Greece and Switzerland) and with 3 academic partners and 4 SMEs. The networking activities planned in REGENERATION will generate new knowledge about the mechanisms of bone growth, regeneration and aging, about drug and technologies development for bone pathologies and will study the effect of QMR stimuli in cell proliferation, differentiation and trasfection by in vitro and computational models.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff Exchanges
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-SE-01
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151 25 MAROUSSI
Greece
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