Project description
Advancing bone health for an aging population
Advancing bone health for an aging populationAgeing bones often lead to fractures and reduced mobility among the elderly. This compromises quality of life and imposes considerable social and economic burdens on healthcare systems. Traditional animal testing methods for understanding bone ageing often fail to accurately represent human-specific features. Supported by the Marie Skłodowska-Curie Actions programme, the REGENERATION project aims to create reliable and sustainable in vitro models of healthy and aged bone tissue. By establishing a research network across France, Greece, Italy, and Switzerland, REGENERATION will explore the effects of Quantum Molecular Resonance (QMR) on bone biology. This initiative will also train scientists to enhance knowledge of bone ageing, fostering personalised therapies and improving preventive care for the elderly.
Objective
REGENERATION aims to build a multidisciplinary research network bringing together complementary expertise in life sciences, bioengineering, medical-device development, computational modelling, artificial intelligence and Quantum Molecular Resonance (QMR) technologies. The project will develop reliable and sustainable in vitro models of healthy and aged bone tissue, treated with or without QMR, and will train a cohort of scientists and technologists in exploiting these models to increase knowledge on bone ageing, mechanobiology, response to physical stimulation and drug-related effects.
Bone ageing reduces the quality of life of elderly people and creates a significant social and economic burden. Ageing bones fail more easily when challenged mechanically or exposed to toxicants or pollutants, and they may respond differently to drugs and physical stimuli compared with healthy bone. To personalise therapies and enable better preventive care for the elderly, it is essential to develop reliable human-based in vitro models of aged bone tissue, reducing dependence on animal models that are costly, ethically sensitive and often unable to capture human-specific features.
REGENERATION will involve 10 active participants from 5 countries: Italy, Greece, Germany, Spain and Switzerland. The consortium brings together universities, research centres and private companies with complementary expertise in cell culture, scaffold optimisation, QMR-based stimulation, dynamic bioreactor culture, microvascularisation, immune-cell interactions, computational modelling, artificial intelligence, bioengineering design and exploitation of biomedical technologies.
The project activities will focus on the development and optimisation of scaffold-based 3D bone models, the use of QMR technology to stimulate and functionalise bone constructs, the integration of vascular and immune-system components to better reproduce relevant in vivo conditions, and the development of computational and data-driven models to support interpretation and optimisation of the experimental results. Dynamic culture systems and advanced culture-device solutions will be used to improve the reproducibility and physiological relevance of the models.
Through international, interdisciplinary and intersectoral staff exchanges, REGENERATION will generate new knowledge on the mechanisms of bone growth, regeneration and ageing, and on the effects of QMR stimuli on cell proliferation, differentiation and transfection. The project will strengthen long-term collaboration between academic and non-academic partners, improve research and innovation capacities across the consortium, and support the development of new tools, protocols and exploitable results in the fields of tissue engineering, regenerative medicine, in vitro testing and biomedical technology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences artificial intelligence
- engineering and technology environmental biotechnology bioremediation bioreactors
- medical and health sciences medical biotechnology tissue engineering
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff Exchanges
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-SE-01
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151 25 MAROUSSI
Greece
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