Objective Biophysical biomarkers of cell state can reveal physiologically relevant changes that occur during disease progression. For example, cell deformability, cytoskeletal and nuclear organization, and macromolecular crowding are biophysical parameters implicated in migration and growth, which are essential processes for cellular functions. As biophysical parameters reflect physio-pathological cell states, they have the potential to be used as biomarkers for early diagnostics and clinical treatments in medicine. Current techniques based on microfluidics can be used to perform biophysical measurements in a high-throughput manner. However, these systems are not able to provide multiparameter, biophysical and same-cell measurements, making it difficult to find insightful relationships in heterogenous cellular mixtures. SameMultiPhys will develop and produce customized microfluidic systems to measure multiple features in the same cells and evaluate their potential applications as biophysical biomarkers. These new technologies will allow us to study multiscale biological questions of immune T cells from an interdisciplinary perspective and other cell lines. This project aims to facilitate the transfer of knowledge and resources between institutions with expertise in microengineering, materials science, chemistry, mathematics, biology, and biophysics to promote collaboration between researchers, and to develop innovative microfluidic technologies for mechanobiology. The project will involve state-of-the-art microfabrication techniques, deep-learning analysis of images, and computational modelling to develop and validate the technologies developed. The ultimate goal of this project is to gain a deeper understanding of the mechanobiology of cells, enabling progress toward more effective identification of biomarkers. Fields of science natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidicsnatural sciencescomputer and information sciencesartificial intelligencemachine learningdeep learningnatural sciencesbiological sciencesbiophysicsnatural sciencesmathematics Keywords Mechanobiology Cell Mechanics Biomarkers Microfluidics Microengineering Cell Biophysical Properties Cell Label-free Biomarkers Quantitative biology Soft Matter Deformability Physics of cells Programme(s) HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme Topic(s) HORIZON-MSCA-2022-SE-01-01 - MSCA Staff Exchanges 2022 Call for proposal HORIZON-MSCA-2022-SE-01 See other projects for this call Funding Scheme HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff Exchanges Coordinator UNIVERSIDAD POLITECNICA DE MADRID Net EU contribution € 69 000,00 Address Calle ramiro de maeztu 7 edificio rectorado 28040 Madrid Spain See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window EU contribution No data Participants (3) Sort alphabetically Sort by Net EU contribution Expand all Collapse all TEL AVIV UNIVERSITY Israel Net EU contribution € 36 800,00 Address Ramat aviv 69978 Tel aviv See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window EU contribution No data UNIVERSITA DEGLI STUDI DI FIRENZE Italy Net EU contribution € 32 200,00 Address Piazza san marco 4 50121 Florence See on map Region Centro (IT) Toscana Firenze Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window EU contribution No data CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France Net EU contribution € 41 400,00 Address Rue michel ange 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window EU contribution No data Partners (4) Sort alphabetically Sort by Net EU contribution Expand all Collapse all NEW YORK UNIVERSITY United States Net EU contribution € 0,00 Address 70 washington square south 10003 1526 New york See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding No data UNIVERSITY OF WASHINGTON United States Net EU contribution € 0,00 Address Brooklyn avenue ne 4333 98195 9472 Seattle wa See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding No data UNIVERSIDAD DE SANTIAGO DE CHILE Chile Net EU contribution € 0,00 Address Avenida libertador bernardo o'higgins 3363 9170022 Santiago See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding No data THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO Canada Net EU contribution € 0,00 Address Kings college circle 27 M5S 1A1 Toronto See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding No data
