REAL-WORLD IMPLEMENTATION, DEPLOYMENT AND VALIDATION OF EARLY DETECTION TOOLS AND LIFESTYLE ENHANCEMENT

Deliverables

AD-RIDDLE communications pack.

AD-RIDDLE communications pack, including visual identity and communication guidelines.

Development of predictive algorithms

Report on predictive algorithms for at-risk/early AD stages based on existing cohorts.

Core protocol for digital cognitive assessments

Core protocol including library of digital cognitive tools for real-world testing.

Communication and dissemination strategy

Report on communication strategy of the project.

Review on ethics of dementia risk

Report scoping review on the ethics of dementia risk communication.

Study initiation package: BBMs Core Protocol with sub-studies

Core Protocol with sub-studies for real-world testing of BBMs.

Study initiation package: Core protocol with all sub-studies for digital cognitive assessments

Core protocol including all sub-studies for real-world testing of digital cognitive

DMP

Addresses the relevant aspects of making the data FAIR – findable, accessible, interoperable and re-usable, including what data the project will generate, whether and how the data will be made accessible for verification and re-use, and how it will be circulated and preserved.

Publications

Real-world brain imaging in a population-based cohort enables accurate markers for dementia

Author(s): Reijo Sund; Juho Seppänen; Elaheh Moradi; Sami Väänänen; Jani Miettinen; Juhana Hakumäki; Toni Rikkonen; Heikki Kröger; Heli Koivumaa-Honkanen; Alina Solomon; Jussi Tohka
Published in: Alzheimer's & Dementia, 2025, ISSN 1552-5279
Publisher: Wiley (John Wiley & Sons)
DOI: 10.1002/ALZ.70227

Mechanisms of interventions targeting modifiable factors for dementia risk reduction

Author(s): Anna Matton, Ruth Stephen, Makrina Daniilidou, Mariagnese Barbera, Vilma Alanko, Marcel Ballin, Jamie Ford, Katri Hemiö, Jenni Lehtisalo, Sabsil López Rocha, Francesca Mangialasche, Tiia Ngandu, Anna Rosenberg, Gazi Saadmaan, Chinedu Udeh-Momoh, Kerttu Uusimäki, Alina Solomon, Miia Kivipelto
Published in: Molecular Neurodegeneration, Issue 20, 2025, ISSN 1750-1326
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13024-025-00845-W

Modernizing diagnosis of Alzheimer's disease: A review of global trends and Asia‐specific perspectives

Author(s): Takeshi Iwatsubo, Reisa A. Sperling, Alicia Algeciras‐Schimnich, Hidenori Arai, Anna M. Barron, Tammie L. S. Benzinger, Maria C. Carrillo, Christopher Chen, Seong Hye Choi, Igor C. Fontana, Jonathan Graff‐Radford, Joshua D. Grill, Judith Heidebrink, Chaur‐Jong Hu, Ryoko Ihara, Takeshi Ikeuchi, Atsushi Iwata, Fanny C. F. Ip, Fasihah Irfani Fitri, Clifford R. Jack, Jee Hyang Jeong, Jianping Jia, Nagaendran Kandiah, SangYun Kim, Hisatomo Kowa, Renaud La Joie, Yoshiki Niimi, Ryoji Noritake, Ozioma C. Okonkwo, Sebastian Palmqvist, Michael S. Rafii, Rema Raman, Yong Shen, Tanya Simuni, Heather M. Snyder, Orapitchaya Sriwannopas, Luke E. Stoeckel, Wiesje M. van der Flier, Huali Wang, Donna M. Wilcock, Henrik Zetterberg, Jin Zhou, Simin Mahinrad, Claire E. Sexton
Published in: Alzheimer's & Dementia, Issue 21, 2025, ISSN 1552-5260
Publisher: Wiley
DOI: 10.1002/ALZ.70536

Enhancing diagnostic precision in Alzheimer's disease: Impact of comorbidities on blood biomarkers for clinical integration

Author(s): Makrina Daniilidou, Ulf Öhlund‐Wistbacka, Göran Hagman, Anna Rosenberg, Nicholas Ashton, Henrik Zetterberg, Kaj Blennow, Anna Matton, Miia Kivipelto
Published in: Alzheimer's & Dementia, Issue 21, 2026, ISSN 1552-5260
Publisher: Wiley
DOI: 10.1002/ALZ.70931

Validation, Deployment, and Real-World Implementation of a Modular Toolbox for Alzheimer's Disease Detection and Dementia Risk Reduction: The AD-RIDDLE Project

Author(s): K. Malzbender, P. Barbarino, P. Barkman Ferrell, A. Bradshaw, A.J. Brookes, C. Díaz, W.M. van der Flier, J. Georges, O. Hansson, M. Hartmanis, L. Jönsson, R. Krishnan, T. MacLeod, F. Mangialasche, P. Mecocci, C. Minguillon, L. Middleton, S. Pla, S.P. Sardi, M. Schöll, M. Suárez-Calvet, W. Weidner, P.J. Visser, H. Zetterberg, N. Bose, A. Solomon, Miia Kivipelto
Published in: The Journal of Prevention of Alzheimer's Disease, Issue 11, 2024, ISSN 2274-5807
Publisher: Elsevier BV
DOI: 10.14283/JPAD.2024.32

Author(s): Rosanne L. van den Berg, Elke Butterbrod, Casper de Boer, Lisa‐Marie Schlüter, Argonde C. van Harten, Charlotte E. Teunissen, Elsmarieke van de Giessen, Wiesje M. van der Flier, Sietske A. M. Sikkes
Published in: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Issue 17, 2025, ISSN 2352-8729
Publisher: Wiley
DOI: 10.1002/DAD2.70063

Plasma p‐tau217 identifies cognitively normal older adults who will develop cognitive impairment in a 10‐year window

Author(s): Yara Yakoub, Fernando Gonzalez‐Ortiz, Nicholas J. Ashton, Christine Déry, Cherie Strikwerda‐Brown, Frédéric St‐Onge, Valentin Ourry, Michael Schöll, Maiya R. Geddes, Simon Ducharme, Maxime Montembeault, Pedro Rosa‐Neto, Jean‐Paul Soucy, John C. S. Breitner, Henrik Zetterberg, Kaj Blennow, Judes Poirier, Sylvia Villeneuve, null null
Published in: Alzheimer's & Dementia, Issue 21, 2025, ISSN 1552-5260
Publisher: Wiley
DOI: 10.1002/ALZ.14537

Associations of Prediabetes, Diabetes and Glucose‐Related Markers With Cognition and Neuroimaging in a 2‐Year Multidomain Lifestyle Randomised Controlled Trial

Author(s): Thais Lorenzo, Tiia Ngandu, Jenni Lehtisalo, Riitta Antikainen, Juan Domingo Gispert, Nina Kemppainen, Tiina Laatikainen, Jaana Lindström, Juha Rinne, Hilkka Soininen, Timo Strandberg, Rafael de la Torre, Jaakko Tuomilehto, Alina Solomon, Miia Kivipelto
Published in: Diabetes/Metabolism Research and Reviews, Issue 41, 2025, ISSN 1520-7552
Publisher: Wiley
DOI: 10.1002/DMRR.70053

Computerized decision support to optimally funnel patients through the diagnostic pathway for dementia

Author(s): Aniek M. van Gils, Antti Tolonen, Argonde C. van Harten, Sinthujah Vigneswaran, Frederik Barkhof, Leonie N. C. Visser, Juha Koikkalainen, Sanna-Kaisa Herukka, Steen Gregers Hasselbalch, Patrizia Mecocci, Anne M. Remes, Hilkka Soininen, Afina W. Lemstra, Charlotte E. Teunissen, Linus Jönsson, Jyrki Lötjönen, Wiesje M. van der Flier, Hanneke F. M. Rhodius-Meester
Published in: Alzheimer's Research & Therapy, Issue 16, 2024, ISSN 1758-9193
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13195-024-01614-5

Association of modifiable risk factors with progression to dementia in relation to amyloid and tau pathology

Author(s): Zsolt Huszár, Alina Solomon, Marie Anne Engh, Vanda Koszovácz, Tamás Terebessy, Zsolt Molnár, Péter Hegyi, András Horváth, Francesca Mangialasche, Miia Kivipelto, Gábor Csukly
Published in: Alzheimer's Research & Therapy, Issue 16, 2024, ISSN 1758-9193
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13195-024-01602-9

Smartphone- and Tablet-Based Tools to Assess Cognition in Individuals With Preclinical Alzheimer Disease and Mild Cognitive Impairment: Scoping Review

Author(s): Rosanne L van den Berg, Sophie M van der Landen, Matthijs J Keijzer, Aniek M van Gils, Maureen van Dam, Kirsten A Ziesemer, Roos J Jutten, John E Harrison, Casper de Boer, Wiesje M van der Flier, Sietske AM Sikkes
Published in: Journal of Medical Internet Research, Issue 27, 2025, ISSN 1438-8871
Publisher: JMIR Publications Inc.
DOI: 10.2196/65297

Focus groups on digital cognitive assessment in the context of Alzheimer's disease

Author(s): Sophie M van der Landen, Rosanne L van den Berg, Matthijs J Keijzer, Mariska N van Liere, Casper de Boer, Leonie N C Visser, Wiesje M van der Flier, Hanneke F M Rhodius-Meester, Sietske A M Sikkes
Published in: DIGITAL HEALTH, Issue 11, 2025, ISSN 2055-2076
Publisher: SAGE Publications
DOI: 10.1177/20552076251318903

Integrating visual assessments and quantification methods for tau PET staging

Author(s): Yuna Gu, Jihwan Yun, Alexis Moscoso, Michael Schöll, Daeun Shin, Eun Hye Lee, Heekyong Kang, Sohyun Yim, Hyunjin Jo, Jun Pyo Kim, Sung Hoon Kang, Hee Jin Kim, Duk L. Na, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez‐Ortiz, Nicholas J Ashton, Hyemin Jang, Michael W. Weiner, Seung Hwan Moon, Hanna Cho, Jae Yong Choi, Kyung Rok Nam, Byung Hyun Byun, Su Yeon Park, Jeong Ho Ha, Soo Hyun Cho, Sang Won Seo, null null
Published in: Alzheimer's & Dementia, Issue 21, 2025, ISSN 1552-5260
Publisher: Wiley
DOI: 10.1002/ALZ.70352

Towards a national registry for Alzheimer’s disease and related dementias: rationale, design, and initial observations of the ABOARD cohort

Author(s): Casper de Boer, Hanneke F. M. Rhodius-Meester, Sophie M. van der Landen, Jurgen Claassen, Romy de Haan, Janne M. Papma, Harro Seelaar, Marleen Kloppenburg-Lagendijk, Barbara van Munster, Marjolein de Vugt, Derk Arts, Marco Blom, Tanja J. de Rijke, Miriam Beusink, Robbert Huijsman, Evert-Ben van Veen, Argonde van Harten, Jort Vijverberg, Marissa Zwan, Henk-Jan Mutsaerts, Sven J. van der Lee, Wiesje M. van der Flier
Published in: Alzheimer's Research & Therapy, Issue 17, 2025, ISSN 1758-9193
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13195-025-01725-7

REAL AD—Validation of a realistic screening approach for early Alzheimer's disease

Author(s): Antoine Leuzy, Fiona Heeman, Iris Bosch, Frida Lenér, Maria Dottori, Kajsa Quitz, Alexis Moscoso, Silke Kern, Henrik Zetterberg, Kaj Blennow, Michael Schöll
Published in: Alzheimer's & Dementia, Issue 20, 2024, ISSN 1552-5260
Publisher: Wiley
DOI: 10.1002/ALZ.14219

Digital remote assessment of speech acoustics in cognitively unimpaired adults: feasibility, reliability and associations with amyloid pathology

Author(s): Rosanne L. van den Berg, Casper de Boer, Marissa D. Zwan, Roos J. Jutten, Mariska van Liere, Marie-Christine A.B.J. van de Glind, Mark A. Dubbelman, Lisa Marie Schlüter, Argonde C. van Harten, Charlotte E. Teunissen, Elsmarieke van de Giessen, Frederik Barkhof, Lyduine E. Collij, Jessica Robin, William Simpson, John E Harrison, Wiesje M. van der Flier, Sietske A.M. Sikkes
Published in: Alzheimer's Research & Therapy, Issue 16, 2024, ISSN 1758-9193
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13195-024-01543-3

Considerations in the clinical use of amyloid PET and CSF biomarkers for Alzheimer's disease

Author(s): Antoine Leuzy, Ariane Bollack, Daniela Pellegrino, Charlotte E. Teunissen, Renaud La Joie, Gil D. Rabinovici, Nicolai Franzmeier, Keith Johnson, Frederik Barkhof, Leslie M. Shaw, Alexander Arkhipenko, Suzanne E. Schindler, Lawrence S. Honig, Alexis Moscoso Rial, Michael Schöll, Henrik Zetterberg, Kaj Blennow, Oskar Hansson, Gill Farrar
Published in: Alzheimer's & Dementia, Issue 21, 2025, ISSN 1552-5260
Publisher: Wiley
DOI: 10.1002/ALZ.14528

A novel approach to resilience and its links with education and Alzheimer's disease genetics

Author(s): Maria Carrigan; Diana I. Bocancea; Jacob Vogel; Anna C. van Loenhoud; Niccoló Tesi; Frederik Barkhof; Paul J. Lucassen; Wiesje M. van der Flier; Harm J. Krugers; Sven J. Van der Lee; Rik Ossenkoppele
Published in: Alzheimer's & Dementia, 2025, ISSN 1552-5279
Publisher: Wiley (John Wiley & Sons)
DOI: 10.1002/ALZ.70379

Additional file 2 of Mechanisms of interventions targeting modifiable factors for dementia risk reduction

Author(s): Matton, Anna; Stephen, Ruth; Daniilidou, Makrina; Barbera, Mariagnese; Alanko, Vilma; Ballin, Marcel; Ford, Jamie; Hemiö, Katri; Lehtisalo, Jenni; Rocha, Sabsil López; Mangialasche, Francesca; Ngandu, Tiia; Rosenberg, Anna; Saadmaan, Gazi; Udeh-Momoh, Chinedu; Uusimäki, Kerttu; Solomon, Alina; Kivipelto, Miia
Published in: 2025
Publisher: Springer Science and Business Media LLC
DOI: 10.6084/M9.FIGSHARE.29388223

Additional file 1 of Association of modifiable risk factors with progression to dementia in relation to amyloid and tau pathology

Author(s): Huszár, Zsolt; Solomon, Alina; Engh, Marie Anne; Koszovácz, Vanda; Terebessy, Tamás; Molnár, Zsolt; Hegyi, Péter; Horváth, András; Mangialasche, Francesca; Kivipelto, Miia; Csukly, Gábor
Published in: 2024
Publisher: Springer Science and Business Media LLC
DOI: 10.6084/M9.FIGSHARE.27312441

Additional file 1 of Mechanisms of interventions targeting modifiable factors for dementia risk reduction

Author(s): Matton, Anna; Stephen, Ruth; Daniilidou, Makrina; Barbera, Mariagnese; Alanko, Vilma; Ballin, Marcel; Ford, Jamie; Hemiö, Katri; Lehtisalo, Jenni; Rocha, Sabsil López; Mangialasche, Francesca; Ngandu, Tiia; Rosenberg, Anna; Saadmaan, Gazi; Udeh-Momoh, Chinedu; Uusimäki, Kerttu; Solomon, Alina; Kivipelto, Miia
Published in: 2025
Publisher: Springer Science and Business Media LLC
DOI: 10.6084/M9.FIGSHARE.29388220.V1

Additional file 1 of Computerized decision support to optimally funnel patients through the diagnostic pathway for dementia

Author(s): van Gils, Aniek M.; Tolonen, Antti; van Harten, Argonde C.; Vigneswaran, Sinthujah; Barkhof, Frederik; Visser, Leonie N. C.; Koikkalainen, Juha; Herukka, Sanna-Kaisa; Hasselbalch, Steen Gregers; Mecocci, Patrizia; Remes, Anne M.; Soininen, Hilkka; Lemstra, Afina W.; Teunissen, Charlotte E.; Jönsson, Linus; Lötjönen, Jyrki; van der Flier, Wiesje M.; Rhodius-Meester, Hanneke F. M.
Published in: 2024
Publisher: Springer Science and Business Media LLC
DOI: 10.6084/M9.FIGSHARE.27907617.V1

Deliverables

Publications

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