REAL-WORLD IMPLEMENTATION, DEPLOYMENT AND VALIDATION OF EARLY DETECTION TOOLS AND LIFESTYLE ENHANCEMENT

Project Information

AD-RIDDLE

Grant agreement ID: 101132933

DOI

10.3030/101132933

EC signature date 13 November 2023

Start date 1 January 2024

End date 31 December 2028

Funded under

• Health

Total cost

€ 29 051 202,25

EU contribution

€ 12 090 250,00

Coordinated by

REGION STOCKHOLM
Sweden

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (10)

AD-RIDDLE communications pack.

AD-RIDDLE communications pack, including visual identity and communication guidelines.

Literature review of funding models

Report on literature review of funding models.

Development of predictive algorithms

Report on predictive algorithms for at-risk/early AD stages based on existing cohorts.

Review on dementia risk reduction

Report on policy and practice review on dementia risk reduction in Europe.

Core protocol for digital cognitive assessments

Core protocol including library of digital cognitive tools for real-world testing.

Communication and dissemination strategy

Report on communication strategy of the project.

Review on ethics of dementia risk

Report scoping review on the ethics of dementia risk communication.

Study initiation package: BBMs Core Protocol with sub-studies

Core Protocol with sub-studies for real-world testing of BBMs.

Study initiation package: Core protocol with all sub-studies for digital cognitive assessments

Core protocol including all sub-studies for real-world testing of digital cognitive

Public awareness strategy

Report on public awareness strategy.

Data Management Plan (1)

DMP

Addresses the relevant aspects of making the data FAIR – findable, accessible, interoperable and re-usable, including what data the project will generate, whether and how the data will be made accessible for verification and re-use, and how it will be circulated and preserved.

Publications

Peer reviewed articles (7)

Real-world brain imaging in a population-based cohort enables accurate markers for dementia

Author(s): Reijo Sund; Juho Seppänen; Elaheh Moradi; Sami Väänänen; Jani Miettinen; Juhana Hakumäki; Toni Rikkonen; Heikki Kröger; Heli Koivumaa-Honkanen; Alina Solomon; Jussi Tohka
Published in: Alzheimer's & Dementia, 2025, ISSN 1552-5279
Publisher: Wiley (John Wiley & Sons)
DOI: 10.1002/ALZ.70227

Mechanisms of interventions targeting modifiable factors for dementia risk reduction

Author(s): Anna Matton, Ruth Stephen, Makrina Daniilidou, Mariagnese Barbera, Vilma Alanko, Marcel Ballin, Jamie Ford, Katri Hemiö, Jenni Lehtisalo, Sabsil López Rocha, Francesca Mangialasche, Tiia Ngandu, Anna Rosenberg, Gazi Saadmaan, Chinedu Udeh-Momoh, Kerttu Uusimäki, Alina Solomon, Miia Kivipelto
Published in: Molecular Neurodegeneration, Issue 20, 2025, ISSN 1750-1326
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13024-025-00845-W

Enhancing diagnostic precision in Alzheimer's disease: Impact of comorbidities on blood biomarkers for clinical integration

Author(s): Makrina Daniilidou, Ulf Öhlund‐Wistbacka, Göran Hagman, Anna Rosenberg, Nicholas Ashton, Henrik Zetterberg, Kaj Blennow, Anna Matton, Miia Kivipelto
Published in: Alzheimer's & Dementia, Issue 21, 2026, ISSN 1552-5260
Publisher: Wiley
DOI: 10.1002/ALZ.70931

Validation, Deployment, and Real-World Implementation of a Modular Toolbox for Alzheimer's Disease Detection and Dementia Risk Reduction: The AD-RIDDLE Project

Author(s): K. Malzbender, P. Barbarino, P. Barkman Ferrell, A. Bradshaw, A.J. Brookes, C. Díaz, W.M. van der Flier, J. Georges, O. Hansson, M. Hartmanis, L. Jönsson, R. Krishnan, T. MacLeod, F. Mangialasche, P. Mecocci, C. Minguillon, L. Middleton, S. Pla, S.P. Sardi, M. Schöll, M. Suárez-Calvet, W. Weidner, P.J. Visser, H. Zetterberg, N. Bose, A. Solomon, Miia Kivipelto
Published in: The Journal of Prevention of Alzheimer's Disease, Issue 11, 2024, ISSN 2274-5807
Publisher: Elsevier BV
DOI: 10.14283/JPAD.2024.32

Associations of Prediabetes, Diabetes and Glucose‐Related Markers With Cognition and Neuroimaging in a 2‐Year Multidomain Lifestyle Randomised Controlled Trial

Author(s): Thais Lorenzo, Tiia Ngandu, Jenni Lehtisalo, Riitta Antikainen, Juan Domingo Gispert, Nina Kemppainen, Tiina Laatikainen, Jaana Lindström, Juha Rinne, Hilkka Soininen, Timo Strandberg, Rafael de la Torre, Jaakko Tuomilehto, Alina Solomon, Miia Kivipelto
Published in: Diabetes/Metabolism Research and Reviews, Issue 41, 2025, ISSN 1520-7552
Publisher: Wiley
DOI: 10.1002/DMRR.70053

Association of modifiable risk factors with progression to dementia in relation to amyloid and tau pathology

Author(s): Zsolt Huszár, Alina Solomon, Marie Anne Engh, Vanda Koszovácz, Tamás Terebessy, Zsolt Molnár, Péter Hegyi, András Horváth, Francesca Mangialasche, Miia Kivipelto, Gábor Csukly
Published in: Alzheimer's Research & Therapy, Issue 16, 2024, ISSN 1758-9193
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13195-024-01602-9

Clinical staging in Swedish primary care using the Amsterdam Instrumental Activities of Daily Living Questionnaire

Author(s): Ayesha Fawad, Sophie M. van der Landen, Pontus Tideman, Angela van der Putten‐Toorenburg, Elke Butterbrod, Ruben Smith, Danielle van Westen, Susanna Calling, Patrik Midlöv, Niklas Mattsson‐Carlgren, Beata Borgström Bolmsjö, Erik Stomrud, Maria H. Nilsson, Oskar Hansson, Sietske A. M. Sikkes, Sebastian Palmqvist
Published in: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Issue 18, 2026, ISSN 2352-8729
Publisher: Wiley
DOI: 10.1002/DAD2.70344