REAL-WORLD IMPLEMENTATION, DEPLOYMENT AND VALIDATION OF EARLY DETECTION TOOLS AND LIFESTYLE ENHANCEMENT

Livrables

AD-RIDDLE communications pack.

AD-RIDDLE communications pack, including visual identity and communication guidelines.

Development of predictive algorithms

Report on predictive algorithms for at-risk/early AD stages based on existing cohorts.

Core protocol for digital cognitive assessments

Core protocol including library of digital cognitive tools for real-world testing.

Communication and dissemination strategy

Report on communication strategy of the project.

Review on ethics of dementia risk

Report scoping review on the ethics of dementia risk communication.

Study initiation package: BBMs Core Protocol with sub-studies

Core Protocol with sub-studies for real-world testing of BBMs.

Study initiation package: Core protocol with all sub-studies for digital cognitive assessments

Core protocol including all sub-studies for real-world testing of digital cognitive

DMP

Addresses the relevant aspects of making the data FAIR – findable, accessible, interoperable and re-usable, including what data the project will generate, whether and how the data will be made accessible for verification and re-use, and how it will be circulated and preserved.

Publications

Real-world brain imaging in a population-based cohort enables accurate markers for dementia

Auteurs: Reijo Sund; Juho Seppänen; Elaheh Moradi; Sami Väänänen; Jani Miettinen; Juhana Hakumäki; Toni Rikkonen; Heikki Kröger; Heli Koivumaa-Honkanen; Alina Solomon; Jussi Tohka
Publié dans: Alzheimer's & Dementia, 2025, ISSN 1552-5279
Éditeur: Wiley (John Wiley & Sons)
DOI: 10.1002/ALZ.70227

Enhancing diagnostic precision in Alzheimer's disease: Impact of comorbidities on blood biomarkers for clinical integration

Auteurs: Makrina Daniilidou, Ulf Öhlund‐Wistbacka, Göran Hagman, Anna Rosenberg, Nicholas Ashton, Henrik Zetterberg, Kaj Blennow, Anna Matton, Miia Kivipelto
Publié dans: Alzheimer's & Dementia, Numéro 21, 2026, ISSN 1552-5260
Éditeur: Wiley
DOI: 10.1002/ALZ.70931

Validation, Deployment, and Real-World Implementation of a Modular Toolbox for Alzheimer's Disease Detection and Dementia Risk Reduction: The AD-RIDDLE Project

Auteurs: K. Malzbender, P. Barbarino, P. Barkman Ferrell, A. Bradshaw, A.J. Brookes, C. Díaz, W.M. van der Flier, J. Georges, O. Hansson, M. Hartmanis, L. Jönsson, R. Krishnan, T. MacLeod, F. Mangialasche, P. Mecocci, C. Minguillon, L. Middleton, S. Pla, S.P. Sardi, M. Schöll, M. Suárez-Calvet, W. Weidner, P.J. Visser, H. Zetterberg, N. Bose, A. Solomon, Miia Kivipelto
Publié dans: The Journal of Prevention of Alzheimer's Disease, Numéro 11, 2024, ISSN 2274-5807
Éditeur: Elsevier BV
DOI: 10.14283/JPAD.2024.32

Auteurs: Rosanne L. van den Berg, Elke Butterbrod, Casper de Boer, Lisa‐Marie Schlüter, Argonde C. van Harten, Charlotte E. Teunissen, Elsmarieke van de Giessen, Wiesje M. van der Flier, Sietske A. M. Sikkes
Publié dans: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Numéro 17, 2025, ISSN 2352-8729
Éditeur: Wiley
DOI: 10.1002/DAD2.70063

Computerized decision support to optimally funnel patients through the diagnostic pathway for dementia

Auteurs: Aniek M. van Gils, Antti Tolonen, Argonde C. van Harten, Sinthujah Vigneswaran, Frederik Barkhof, Leonie N. C. Visser, Juha Koikkalainen, Sanna-Kaisa Herukka, Steen Gregers Hasselbalch, Patrizia Mecocci, Anne M. Remes, Hilkka Soininen, Afina W. Lemstra, Charlotte E. Teunissen, Linus Jönsson, Jyrki Lötjönen, Wiesje M. van der Flier, Hanneke F. M. Rhodius-Meester
Publié dans: Alzheimer's Research & Therapy, Numéro 16, 2024, ISSN 1758-9193
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S13195-024-01614-5

Association of modifiable risk factors with progression to dementia in relation to amyloid and tau pathology

Auteurs: Zsolt Huszár, Alina Solomon, Marie Anne Engh, Vanda Koszovácz, Tamás Terebessy, Zsolt Molnár, Péter Hegyi, András Horváth, Francesca Mangialasche, Miia Kivipelto, Gábor Csukly
Publié dans: Alzheimer's Research & Therapy, Numéro 16, 2024, ISSN 1758-9193
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S13195-024-01602-9

Focus groups on digital cognitive assessment in the context of Alzheimer's disease

Auteurs: Sophie M van der Landen, Rosanne L van den Berg, Matthijs J Keijzer, Mariska N van Liere, Casper de Boer, Leonie N C Visser, Wiesje M van der Flier, Hanneke F M Rhodius-Meester, Sietske A M Sikkes
Publié dans: DIGITAL HEALTH, Numéro 11, 2025, ISSN 2055-2076
Éditeur: SAGE Publications
DOI: 10.1177/20552076251318903

REAL AD—Validation of a realistic screening approach for early Alzheimer's disease

Auteurs: Antoine Leuzy, Fiona Heeman, Iris Bosch, Frida Lenér, Maria Dottori, Kajsa Quitz, Alexis Moscoso, Silke Kern, Henrik Zetterberg, Kaj Blennow, Michael Schöll
Publié dans: Alzheimer's & Dementia, Numéro 20, 2024, ISSN 1552-5260
Éditeur: Wiley
DOI: 10.1002/ALZ.14219

Digital remote assessment of speech acoustics in cognitively unimpaired adults: feasibility, reliability and associations with amyloid pathology

Auteurs: Rosanne L. van den Berg, Casper de Boer, Marissa D. Zwan, Roos J. Jutten, Mariska van Liere, Marie-Christine A.B.J. van de Glind, Mark A. Dubbelman, Lisa Marie Schlüter, Argonde C. van Harten, Charlotte E. Teunissen, Elsmarieke van de Giessen, Frederik Barkhof, Lyduine E. Collij, Jessica Robin, William Simpson, John E Harrison, Wiesje M. van der Flier, Sietske A.M. Sikkes
Publié dans: Alzheimer's Research & Therapy, Numéro 16, 2024, ISSN 1758-9193
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S13195-024-01543-3

A novel approach to resilience and its links with education and Alzheimer's disease genetics

Auteurs: Maria Carrigan; Diana I. Bocancea; Jacob Vogel; Anna C. van Loenhoud; Niccoló Tesi; Frederik Barkhof; Paul J. Lucassen; Wiesje M. van der Flier; Harm J. Krugers; Sven J. Van der Lee; Rik Ossenkoppele
Publié dans: Alzheimer's & Dementia, 2025, ISSN 1552-5279
Éditeur: Wiley (John Wiley & Sons)
DOI: 10.1002/ALZ.70379

Additional file 2 of Mechanisms of interventions targeting modifiable factors for dementia risk reduction

Auteurs: Matton, Anna; Stephen, Ruth; Daniilidou, Makrina; Barbera, Mariagnese; Alanko, Vilma; Ballin, Marcel; Ford, Jamie; Hemiö, Katri; Lehtisalo, Jenni; Rocha, Sabsil López; Mangialasche, Francesca; Ngandu, Tiia; Rosenberg, Anna; Saadmaan, Gazi; Udeh-Momoh, Chinedu; Uusimäki, Kerttu; Solomon, Alina; Kivipelto, Miia
Publié dans: 2025
Éditeur: Springer Science and Business Media LLC
DOI: 10.6084/M9.FIGSHARE.29388223

Additional file 1 of Association of modifiable risk factors with progression to dementia in relation to amyloid and tau pathology

Auteurs: Huszár, Zsolt; Solomon, Alina; Engh, Marie Anne; Koszovácz, Vanda; Terebessy, Tamás; Molnár, Zsolt; Hegyi, Péter; Horváth, András; Mangialasche, Francesca; Kivipelto, Miia; Csukly, Gábor
Publié dans: 2024
Éditeur: Springer Science and Business Media LLC
DOI: 10.6084/M9.FIGSHARE.27312441

Additional file 1 of Mechanisms of interventions targeting modifiable factors for dementia risk reduction

Auteurs: Matton, Anna; Stephen, Ruth; Daniilidou, Makrina; Barbera, Mariagnese; Alanko, Vilma; Ballin, Marcel; Ford, Jamie; Hemiö, Katri; Lehtisalo, Jenni; Rocha, Sabsil López; Mangialasche, Francesca; Ngandu, Tiia; Rosenberg, Anna; Saadmaan, Gazi; Udeh-Momoh, Chinedu; Uusimäki, Kerttu; Solomon, Alina; Kivipelto, Miia
Publié dans: 2025
Éditeur: Springer Science and Business Media LLC
DOI: 10.6084/M9.FIGSHARE.29388220.V1

Additional file 1 of Computerized decision support to optimally funnel patients through the diagnostic pathway for dementia

Auteurs: van Gils, Aniek M.; Tolonen, Antti; van Harten, Argonde C.; Vigneswaran, Sinthujah; Barkhof, Frederik; Visser, Leonie N. C.; Koikkalainen, Juha; Herukka, Sanna-Kaisa; Hasselbalch, Steen Gregers; Mecocci, Patrizia; Remes, Anne M.; Soininen, Hilkka; Lemstra, Afina W.; Teunissen, Charlotte E.; Jönsson, Linus; Lötjönen, Jyrki; van der Flier, Wiesje M.; Rhodius-Meester, Hanneke F. M.
Publié dans: 2024
Éditeur: Springer Science and Business Media LLC
DOI: 10.6084/M9.FIGSHARE.27907617.V1

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