CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.
Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .
Livrables
For sponge cell line the process will be developped on Geodia barretti and then applied to another species of sponges targeted in the project: Haplosclerida or Crambeidae. WU will demonstrate the transfer of TRL from 2 to 4. This will represent a key output of task 3.2
Seaweed cell cultures for Dictyota sp. and Laurencia sp. (s’ouvre dans une nouvelle fenêtre)Hortimare will expand the current collection of brown and red seaweed species' gametophytes and sporophytes, which includes cultures of S. latissima, A. taxiformis and Palmaria palmata.This creates a stable supply of stable seaweed cultures to use as model species in developing protocols for the propagation of Dictyota sp. and Laurencia sp. The cultures of model species will be used for deliverable D3.6, co-culture system of seaweed cell lines. The set up cultures of Dictyota sp. and Laurencia sp. will contribute to all further research on terpene extraction and scaling up terpene production, for example D4.1, Annotation of terpenoids in Laurencia and Dictyota as well as the scaling up of cultures at UG. This will correspond to the change of TRL from 3 to 5. This will correspond mainly to task 3.1
A website will be developped for COMBO that will include a link towards a sharepoint and the webdatabase. This will be addressed early in the project and will address task 8.2
Visual identity of COMBO (s’ouvre dans une nouvelle fenêtre)A logo and templates for presentations and leaflets will be developped for COMBO. This will be addressed early in the project and will address task 8.2
The first policy brief will detail the value of untapped natural marine resources for novel applications in the blue bioeconomy. To this end, recommendations of areas that need to be considered for special environmental protection will be identified. Predictions of hotspots for biodiversity and biodiscovery will be made and sites identified for protection. This will correspond to part of the work on task 8.1NKUA will contribute to this deliverable
Events during COMBO (s’ouvre dans une nouvelle fenêtre)A first report will be made about events organised within COMBO: workshops and outreach activities. This will be an important component of task 8.2NKUA will contribute to this deliverable
Reporter cell lines for 4 marine microorganisms (s’ouvre dans une nouvelle fenêtre)Genomic data and omics-based gene-to-molecule association algorithms will be used to link metabolites to putative biosynthetic genes in both the host and the microbiome, which can then be prioritized for experimental characterisation. It will be part of task 5.1
Project management guidelines (s’ouvre dans une nouvelle fenêtre)Details about the management of the project with input from all partners will be provided. A teams group will be created and guidelines will be provided about the management of the project as indicated in Task 1.1. The consortium agreement will also be signed
Annotation of alkaloids in sponges (s’ouvre dans une nouvelle fenêtre)GALWAY will develop a database of alkaloids: PGA from Crambeidae and 3-AP from Haplosclerida to be used for metabolomic studies on these groups MS/MS and NMR data will be stored. It will correspond to task 4.1 and will be enriched with the natural products isolated during the project and reported in D4.5
Annotation of acetogenins in Laurencia (s’ouvre dans une nouvelle fenêtre)A database of C15 acetogenins from Laurencia will be produced and this will correspond to the task 4.2
Identification of suitable seaweed and sponge candidates (s’ouvre dans une nouvelle fenêtre)A list of terpene-producing seaweeds and alkaloid-producing sponges will be sourced from the literature. Common species or closely related species in the same genera from the north west, north east and south east Atlantic will be given priority for collection so as to optimally benefit from partners from a wide geographic area. All specimens will be saved as vouchers and identified using morphology (microcopy) and a multigene barcoding approach. All barcodes will be uploaded onto Genbank. This will report part of the work from tasks 2.1
Annotation of terpenoids in Laurencia and Dictyota (s’ouvre dans une nouvelle fenêtre)GALWAY will prepare a database of metabolites from the two genera of seaweeds to be used during the metabolomic studies. MS/MS and NMR data will be generated and stored for model species of Dictyota and Laurencia. It will be part of task 4.1 as a first step but will be enriched later with data and compounds purified during the project in D4.6NKUA will contribute to this deliverable
Environmental footprints for bioactive compounds (s’ouvre dans une nouvelle fenêtre)Based on Product Environmental Footprint methodology, 16 environmental indicators will be calculated for key processes involved in bioactive compound extraction. A report will describe the methodology behind these process footprints, including system diagrams and life cycle inventories, to ensure full transparency and addressing task 7.1NKUA will contribute to this deliverable
Structures 4 families of metabolites for biological profiling (s’ouvre dans une nouvelle fenêtre)The first set of molecules from the 4 targeted families will be provided by GALWAY and MEDINA to MEDINA, UA and USC for biological profiling in order to address tasks 6.2 6.3 and 6.4NKUA will contribute to this deliverable
Optimized purification procedures for target molecules (s’ouvre dans une nouvelle fenêtre)SOP will be developed for the extraction and purification of all 4 targeted families of natural products produced either by the holobiont from GALWAY or an associated bacteria/fungus from MEDINA. This will address task 6.1NKUA will contribute to this deliverable
Dissemination and communication plan (s’ouvre dans une nouvelle fenêtre)Dissemination and communication plan will be developped including outreach activities and public engagement with all local partners especially where the samples are collected: South Africa, Ireland and French Guiana. This deliverable will capture information from tasks 8.1 and 8.2 and will be completed by D8.10
Certification for GMO manipulation and ABS (s’ouvre dans une nouvelle fenêtre)Certification will be obtained for GMO by DTU and permits for ABS will be obtained for additional collections by GALWAY UCT and CNRS. This will be part of the ethical issues in COMBO and related to task 1.3
A second version of the data management plan will be elaborated before the first reporting period and will still contribute to task 1.2NKUA will contribute to this deliverable
Data Management Plan 6 (s’ouvre dans une nouvelle fenêtre)A first version of the data management plan will be elaborated after 6 months of COMBO in task 1.2. It will be updated in the same task for the following deliverables 1.3 and 1.4
The webdatabase will be created for all samples collected and studied in COMBO and will correspond to Tasks 8.1 and 8.2 to disseminate the less sensitive information on a CMS. It will be linked to WP2. In WP2 2 deliverables will report all the information uploaded in the webdatase. Improvement is expected for the system until the end of the project
Publications
Auteurs:
Juan Ortega-Vidal, Maggie M. Reddy, Nadia Pérez-Fuentes, Rebeca Alvariño, Svenja Burth, Amparo Alfonso, Carmen Vale, Jorge R. Virués-Segovia, Augustine Mungkaje, Luis M. Botana, Olivier P. Thomas
Publié dans:
Journal of Natural Products, Numéro 88, 2025, ISSN 0163-3864
Éditeur:
American Chemical Society (ACS)
DOI:
10.1021/ACS.JNATPROD.5C00118
Auteurs:
Camille V. Leal, André Bispo, Mirelle Takaki, Vitor F. Freire, Maggie M. Reddy, Fabiano L. Thompson, Eduardo Hajdu, Olivier P. Thomas, Roberto G.S. Berlinck
Publié dans:
Biochemical Systematics and Ecology, Numéro 120, 2025, ISSN 0305-1978
Éditeur:
Elsevier BV
DOI:
10.1016/J.BSE.2025.104971
Auteurs:
Rebeca Alvariño, Amparo Alfonso, Jioji N. Tabudravu, Jesús González-Jartín, Khalid S. Al Maqbali, Marwa Elhariry, Mercedes R. Vieytes, Luis M. Botana
Publié dans:
Journal of Natural Products, Numéro 87, 2024, ISSN 0163-3864
Éditeur:
American Chemical Society (ACS)
DOI:
10.1021/ACS.JNATPROD.4C00153
Auteurs:
Laurence K. Jennings, Filippo Spriano, Maggie M. Reddy, Luciano Cascione, Elisa Civanelli, Andrea Rinaldi, Francesco Bertoni, Olivier P. Thomas
Publié dans:
ChemBioChem, 2025, ISSN 1439-4227
Éditeur:
Wiley
DOI:
10.1002/CBIC.202500500
Auteurs:
Castedo Caldeiro, Noelia; Alfonso Rancaño, María Amparo; Alvariño Romero, Rebeca; Rodríguez Vieytes, Mercedes; Botana López, Luis Miguel
Publié dans:
Molecular Neurobiology, 2025, ISSN 1559-1182
Éditeur:
Springer
DOI:
10.1007/S12035-025-04921-6
Auteurs:
Adrian Galitz; Sergio Vargas; Olivier P. Thomas; Maggie M. Reddy; Gert Wörheide; Dirk Erpenbeck
Publié dans:
Chemistry and Biodiversity, 2024, ISSN 1612-1880
Éditeur:
Wiley
DOI:
10.1002/CBDV.202400549
Auteurs:
Sébastien Besseau, Mickael Durand, Duchesse-Lacours Zamar, Enzo Lezin, Louis-Valentin Méteignier, Caroline Birer Williams, Christelle Dutilleul, Thomas Perrot, Arnaud Lanoue, Audrey Oudin, Nicolas Papon, Georges Massiot, Chao Sun, Benoit St-Pierre, Vincent Courdavault
Publié dans:
Plant Communications, Numéro 6, 2025, ISSN 2590-3462
Éditeur:
Elsevier BV
DOI:
10.1016/J.XPLC.2025.101381
Auteurs:
Lezin, Enzo; Papon, Nicolas; Courdavault, Vincent
Publié dans:
Plant Communications, 2025, ISSN 2590-3462
Éditeur:
Cell Press - Elsevier
DOI:
10.1016/J.XPLC.2024.101201
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