A CEllulaR immunoTherapy virtuAl twin for personalIsed cancer treatmeNT

Información del proyecto

CERTAINTY

Identificador del acuerdo de subvención: 101136379

DOI

10.3030/101136379

Fecha de la firma de la CE 11 Diciembre 2023

Fecha de inicio 1 Diciembre 2023

Fecha de finalización 31 Mayo 2028

Financiado con arreglo a

• Health

Coste total

€ 10 060 452,50

Aportación de la UE

€ 9 999 252,50

Coordinado por

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (1)

Project website

Website presenting the project to the general public

Data Management Plan (1)

Data Quality Management Plan

1st version of plan describing the steps, measurements, and KPIs for assuring the project's utilization of high quality data (will be continuously updated)

Documents, reports (3)

Plan for dissemination, communication & exploitation

Report detailing the plan for dissemination & communication

"FAIR ""cookbook"""

Description of FAIRification methods for the project released

1st stakeholder workshop

Multi-disciplinary, multi-initiative, and multi-stakeholder workshop to revise specified VT requirements

Publicaciones

Peer reviewed articles (11)

Emerging T-cell lymphomas after CAR T-cell therapy

Autores: Till Braun, Florian Kuschel, Kristin Reiche, Maximilian Merz, Marco Herling
Publicado en: Leukemia, Edición 39, 2025, ISSN 0887-6924
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41375-025-02574-X

Remission conversion drives outcomes after CAR T-cell therapy for multiple myeloma: a registry analysis from the DRST

Autores: Maximilian Merz, Nico Gagelmann, Samih Smaili, Sarah Flossdorf, Sandra Sauer, Christof Scheid, Bastian von Tresckow, Gerald Georg Wulf, Katja C Weisel, Igor Blau, Monika Engelhardt, Ralph Wäsch, Natalie Schub, Raphael Teipel, Judith S. Hecker, Johannes M. Waldschmidt, Britta Besemer, Ben-Niklas Baermann, Simon Call, Leo Hansmann, Francis Ayuketang Ayuk, Marc S. Raab, Hermann Einsele, Uwe Platzbecker, Nicolaus Kröger
Publicado en: Blood Journal, 2025, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/BLOOD.2025028330

Building multiscale models with PhysiBoSS, an agent-based modeling tool

Autores: Marco Ruscone, Andrea Checcoli, Randy Heiland, Emmanuel Barillot, Paul Macklin, Laurence Calzone, Vincent Noël
Publicado en: Briefings in Bioinformatics, Edición 25, 2024, ISSN 1467-5463
Editor: Oxford University Press (OUP)
DOI: 10.1093/BIB/BBAE509

Virtual twins for personalised CAR T-cell therapy in myeloma

Autores: Kristin Reiche, Ulrike Weirauch, Markus Kreuz, Luise Fischer, Luuk Gras, Thomas Neumuth, Uwe Platzbecker, Ulrike Köhl, Regina Demlova, Andreas Kremer, Holger Fröhlich, Stefan Franke, Maximilian Merz, Colin Birkenbihl, Miriam Alb, Maria Quaranta, Laurence Calzone, Sophia Orozco-Ruiz, Stefanie Binder, Solène Clavreul, Morine Maguri, Maximilian Ferle, Michael Rade, Guillaume Azarias, Jay R. Hydren, Jakub Jamarik, Daniel Schwarz, Zsolt Sebastyen, Jurgen Kuball, Georg Popp, Chloé Antoine, Manon Knockaert, Clara T. Schoeder, David Fandrei, Carmen Sanges, Vaclovas Radvilas, Nico Gagelmann, Markus Rückert, Olaf Penack, Stephan Fricke, Andreas Schmidt, Carol Ward, Carl Steinbeisser, Jean-Marc Van Gyseghem, Anna Niarakis, Laurent Garderet, Michael Hudecek
Publicado en: The Lancet Haematology, Edición 12, 2025, ISSN 2352-3026
Editor: Elsevier BV
DOI: 10.1016/S2352-3026(25)00170-X

Immune digital twins for complex human pathologies: applications, limitations, and challenges

Autores: Anna Niarakis, Reinhard Laubenbacher, Gary An, Yaron Ilan, Jasmin Fisher, Åsmund Flobak, Kristin Reiche, María Rodríguez Martínez, Liesbet Geris, Luiz Ladeira, Lorenzo Veschini, Michael L. Blinov, Francesco Messina, Luis L. Fonseca, Sandra Ferreira, Arnau Montagud, Vincent Noël, Malvina Marku, Eirini Tsirvouli, Marcella M. Torres, Leonard A. Harris, T. J. Sego, Chase Cockrell, Amanda E. Shick, Hasan Balci, Albin Salazar, Kinza Rian, Ahmed Abdelmonem Hemedan, Marina Esteban-Medina, Bernard Staumont, Esteban Hernandez-Vargas, Shiny Martis B, Alejandro Madrid-Valiente, Panagiotis Karampelesis, Luis Sordo Vieira, Pradyumna Harlapur, Alexander Kulesza, Niloofar Nikaein, Winston Garira, Rahuman S. Malik Sheriff, Juilee Thakar, Van Du T. Tran, Jose Carbonell-Caballero, Soroush Safaei, Alfonso Valencia, Andrei Zinovyev, James A. Glazier
Publicado en: npj Systems Biology and Applications, Edición 10, 2024, ISSN 2056-7189
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41540-024-00450-5

Single-cell multiomic dissection of response and resistance to chimeric antigen receptor T cells against BCMA in relapsed multiple myeloma

Autores: Michael Rade, Nora Grieb, Ronald Weiss, Jaren Sia, Luise Fischer, Patrick Born, Andreas Boldt, Stephan Fricke, Paul Franz, Jonathan Scolnick, Lakshmi Venkatraman, Stacy Xu, Christina Kloetzer, Simone Heyn, Anne Sophie Kubasch, Ronny Baber, Song Yau Wang, Enrica Bach, Sandra Hoffmann, Jule Ussmann, Birthe Schetschorke, Saskia Hell, Sebastian Schwind, Klaus H. Metzeler, Marco Herling, Madlen Jentzsch, Georg-Nikolaus Franke, Ulrich Sack, Ulrike Köhl, Uwe Platzbecker, Kristin Reiche, Vladan Vucinic, Maximilian Merz
Publicado en: Nature Cancer, Edición 5, 2024, ISSN 2662-1347
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S43018-024-00763-8

Prognostic implications of splenomegaly in BCMA-directed CAR T-Cell therapy for relapsed myeloma

Autores: Thomas Wiemers, Maximilian Ferle, Jonas Ader, Veronika Sotikova, David Fandrei, Nora Grieb, Luise Fischer, Patrick Born, Heike Weidner, Song Yau Wang, Madlen Jentzsch, Georg-Nikolaus Franke, Carmen Herling, Klaus Metzeler, Marco Herling, Simone Heyn, Timm Denecke, Kristin Reiche, Uwe Platzbecker, Vladan Vucinic, Thomas Neumuth, Hans-Jonas Meyer, Maximilian Merz
Publicado en: Transplantation and Cellular Therapy, 2025, ISSN 2666-6367
Editor: Elsevier BV
DOI: 10.1016/J.JTCT.2025.07.003

Bispecific Antibodies as Bridging to BCMA CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma

Autores: David Fandrei, Sabine Seiffert, Michael Rade, Susanne Rieprecht, Nico Gagelmann, Patrick Born, Thomas Wiemers, Heike Weidner, Markus Kreuz, Tamara Schassberger, Jannik Koßmann, Marlene Mangold, Daniel Fürst, Luise Fischer, Ronny Baber, Simone Heyn, Song Yau Wang, Enrica Bach, Sandra Hoffmann, Klaus H. Metzeler, Marco Herling, Madlen Jentzsch, Georg-Nikolaus Franke, Ulrike Köhl, Maik Friedrich, Andreas Boldt, Kristin Reiche, Uwe Platzbecker, Vladan Vucinic, Maximilian Merz
Publicado en: Blood Cancer Discovery, Edición 6, 2025, ISSN 2643-3230
Editor: American Association for Cancer Research (AACR)
DOI: 10.1158/2643-3230.BCD-24-0118

Multiomic profiling of T cell lymphoma after therapy with anti-BCMA CAR T cells and GPRC5D-directed bispecific antibody

Autores: Till Braun, Michael Rade, Maximilian Merz, Hanna Klepzig, Florian Große, David Fandrei, Nhu-Nguyen Pham, Markus Kreuz, Christina Katharina Kuhn, Florian Kuschel, Dennis Löffler, Jörn Meinel, Eva Heger, Viola Schweinsberg, Natali Pflug, Uwe Platzbecker, Michael Hallek, Udo Holtick, Ulrike Köhl, Christof Scheid, Kristin Reiche, Marco Herling, Tim Richardson
Publicado en: Nature Medicine, Edición 31, 2025, ISSN 1078-8956
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41591-025-03499-9

Predicting progression events in multiple myeloma from routine blood work

Autores: Maximilian Ferle, Nora Grieb, Markus Kreuz, Jonas Ader, Hartmut Goldschmidt, Elias K. Mai, Uta Bertsch, Uwe Platzbecker, Thomas Neumuth, Kristin Reiche, Alexander Oeser, Maximilian Merz
Publicado en: npj Digital Medicine, Edición 8, 2025, ISSN 2398-6352
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41746-025-01636-9

Prognostic significance of PET/CT for CAR T cell therapy in relapsed/refractory multiple myeloma

Autores: Patrick Born, David Fandrei, Song Yau Wang, Carmen Perez‐Fernandez, Luise Fischer, Jule Ussmann, Enrica Bach, Sandra Hoffmann, Klaus H. Metzeler, Marco Herling, Carmen Herling, Madlen Jentzsch, Andreas Boldt, Sabine Seiffert, Ronny Baber, Heike Weidner, Georg‐Nikolaus Franke, Timm Denecke, Osama Sabri, Uwe Platzbecker, Vladan Vucinic, Hans Jonas Meyer, Lars Kurch, Maximilian Merz
Publicado en: HemaSphere, Edición 9, 2025, ISSN 2572-9241
Editor: Wiley
DOI: 10.1002/HEM3.70159