TUMOUR-HOST INTERACTIONS IN LIVER CANCER OF CHILDHOOD AND ADULTS

Project Information

THRIVE

Grant agreement ID: 101136622

DOI

10.3030/101136622

EC signature date 11 December 2023

Start date 1 December 2023

End date 30 November 2028

Funded under

• Health

Total cost

€ 10 396 703,00

EU contribution

€ 10 396 703,00

Coordinated by

FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (19)

HBV-related HCC development in mice is STAT3 dependent and indicates an oncogenic effect of HBx

Author(s): Marc Ringelhan, Svenja Schuehle, Maarten van de Klundert, Elena Kotsiliti, Marie-Laure Plissonnier, Suzanne Faure-Dupuy, Tobias Riedl, Sebastian Lange, Karin Wisskirchen, Frank Thiele, Cho-Chin Cheng, Detian Yuan, Valentina Leone, Ronny Schmidt, Juliana Hünergard, Fabian Geisler, Kristian Unger, Hana Algül, Roland M. Schmid, Roland Rad, Heiner Wedemeyer, Massimo Levrero, Ulrike Protzer, Mathias Heikenwalder
Published in: JHEP Reports, Issue 6, 2024, ISSN 2589-5559
Publisher: Elsevier BV
DOI: 10.1016/J.JHEPR.2024.101128

Preneoplastic liver colonization by 11p15.5 altered mosaic cells in young children with hepatoblastoma

Author(s): Jill Pilet, Theo Z. Hirsch, Barkha Gupta, Amélie Roehrig, Guillaume Morcrette, Aurore Pire, Eric Letouzé, Brice Fresneau, Sophie Taque, Laurence Brugières, Sophie Branchereau, Christophe Chardot, Isabelle Aerts, Sabine Sarnacki, Monique Fabre, Catherine Guettier, Sandra Rebouissou, Jessica Zucman-Rossi
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-023-42418-9

Ribosomal S6 kinase 1 regulates inflammaging via the senescence secretome

Author(s): Suchira Gallage, Elaine E. Irvine, Jose Efren Barragan Avila, Virinder Reen, Silvia M. A. Pedroni, Imanol Duran, Vikas Ranvir, Sanjay Khadayate, Joaquim Pombo, Sharon Brookes, Danijela Heide, Gopuraja Dharmalingham, Agharul I. Choudhury, Indrabahadur Singh, Nicolás Herranz, Santiago Vernia, Mathias Heikenwalder, Jesús Gil, Dominic J. Withers
Published in: Nature Aging, Issue 4, 2024, ISSN 2662-8465
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S43587-024-00695-Z

Adjuvant and neoadjuvant immunotherapies in hepatocellular carcinoma

Author(s): Josep M. Llovet, Roser Pinyol, Mark Yarchoan, Amit G. Singal, Thomas U. Marron, Myron Schwartz, Eli Pikarsky, Masatoshi Kudo, Richard S. Finn
Published in: Nature Reviews Clinical Oncology, Issue 21, 2024, ISSN 1759-4774
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41571-024-00868-0

Adjuvant and neoadjuvant immunotherapies in hepatocellular carcinoma

Author(s): Josep M. Llovet, Roser Pinyol, Mark Yarchoan, Amit G. Singal, Thomas U. Marron, Myron Schwartz, Eli Pikarsky, Masatoshi Kudo, Richard S. Finn
Published in: Nature Reviews Clinical Oncology, Issue 21, 2024, ISSN 1759-4774
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41571-024-00868-0

Oncogenic role of PMEPA1 and its association with immune exhaustion and TGF-β activation in HCC

Author(s): Marta Piqué-Gili, Carmen Andreu-Oller, Agavni Mesropian, Roger Esteban-Fabró, Marina Bárcena-Varela, Marina Ruiz de Galarreta, Carla Montironi, Iris Martinez-Quetglas, Sarah Cappuyns, Judit Peix, Ieva Keraite, Albert Gris-Oliver, Elisa Fernández-Martínez, Ezequiel Mauro, Miguel Torres-Martin, Jordi Abril-Fornaguera, Katherine E. Lindblad, Diether Lambrechts, Jeroen Dekervel, Swan N. Thung, Daniela Sia, Amaia Lujambio, Roser Pinyol, Josep M. Llovet
Published in: JHEP Reports, Issue 6, 2024, ISSN 2589-5559
Publisher: Elsevier BV
DOI: 10.1016/J.JHEPR.2024.101212

Mutational signature, cancer driver genes mutations and transcriptomic subgroups predict HB survival.

Author(s): Pire A, Hirsch TZ, … Zucman-Rossi J.
Published in: Eur J Cancer., Issue 200, 2024, ISSN 0346-251X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/J.EJCA.2024.113583.EPUB2024FEB1

Modeling cancer–microbiome interactions in vitro: A guide to co‐culture platforms

Author(s): Kamil Moskal, Nimisha Khurana, Luisa Siegert, Ye Seul Lee, Hans Clevers, Eran Elinav, Jens Puschhof
Published in: International Journal of Cancer, 2025, ISSN 0020-7136
Publisher: Wiley
DOI: 10.1002/ijc.35298

Molecular insights into early malignant transition of hepatocellular carcinoma

Author(s): Zhengtao Zhang; Hong Li; Lingli Chen; Tao lu; Xinyi Shentu; Yuanhua Liu; Shuyi Ji; Zhixin Qiu; Yining Zou; Hong Wen; Jing Han; Zhengzeng Jiang; Jie Fan; Dianfan Li; Agavni Mesropian; Roser Pinyol; Josep M Llovet; Hui Dong; Yuan Ji; Lijian Hui
Published in: bioRxiv, 2025, ISSN 2692-8205
Publisher: -
DOI: 10.1101/2025.04.14.648739

Diet-microbiome interactions in cancer

Author(s): Suhaib K. Abdeen, Ignacio Mastandrea, Nina Stinchcombe, Jens Puschhof, Eran Elinav
Published in: Cancer Cell, Issue 43, 2025, ISSN 1535-6108
Publisher: Elsevier BV
DOI: 10.1016/J.CCELL.2025.03.013

Neoadjuvant atezolizumab plus bevacizumab prior liver transplantation for hepatocellular carcinoma

Author(s): Parissa Tabrizian, Rebecca Marino, Sherrie Bhoori, Marcus Zeitlhoefler, Neil Mehta, Vanessa Banz, Salvatore Gruttadauria, Massimo Iavarone, Chiara Mazzarelli, Nicolò Simonotti, Francis Yao, Vincenzo Mazzaferro, Josep M. Llovet
Published in: JHEP Reports, Issue 7, 2025, ISSN 2589-5559
Publisher: Elsevier BV
DOI: 10.1016/J.JHEPR.2024.101246

Single-cell Profiling of Intrahepatic Immune Cells Reveals an Expansion of Tissue-resident Cytotoxic CD4+ T Lymphocyte Subset Associated With Pathogenesis of Alcoholic-associated Liver Diseases

Author(s): Chao Gao, Shiguan Wang, Xiaoyu Xie, Pierluigi Ramadori, Xinying Li, Xiaoyu Liu, Xue Ding, Jinyuan Liang, Bowen Xu, Yawei Feng, Xueying Tan, Haoran Wang, Yan Zhang, Haiyan Zhang, Tingguo Zhang, Ping Mi, Shiyang Li, Cuijuan Zhang, Detian Yuan, Mathias Heikenwalder, Peng Zhang
Published in: Cellular and Molecular Gastroenterology and Hepatology, Issue 19, 2025, ISSN 2352-345X
Publisher: Elsevier BV
DOI: 10.1016/j.jcmgh.2024.101411

Hepatocellular carcinoma hosts cholinergic neural cells and tumoral hepatocytes harboring targetable muscarinic receptors

Author(s): Charlotte A. Hernandez, Claire Verzeroli, Armando Andres Roca Suarez, Abud-José Farca-Luna, Laurie Tonon, Roger Esteban-Fabró, Roser Pinyol, Marie-Laure Plissonnier, Ievgeniia Chicherova, Anaëlle Dubois, Pascale Bellaud, Marine Seffals, Bruno Turlin, Alain Fautrel, Gabriel Ichim, Michel Rivoire, Guillaume Passot, Zuzana Macek-Jilkova, Thomas Decaens, Alain Viari, Barbara Testoni, Sandra Rebouissou, Josep M. Llovet, Fabien Zoulim, Romain Parent
Published in: JHEP Reports, Issue 7, 2025, ISSN 2589-5559
Publisher: Elsevier BV
DOI: 10.1016/J.JHEPR.2024.101245

Immune exclusion in hepatoblastoma: is β-catenin to blame again?

Author(s): Theo Z. Hirsch
Published in: Journal of Hepatology, 2025, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/J.JHEP.2025.05.005

A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1

Author(s): Suchira Gallage, Adnan Ali, Jose Efren Barragan Avila, Nogayhan Seymen, Pierluigi Ramadori, Vera Joerke, Laimdota Zizmare, David Aicher, Indresh K. Gopalsamy, Winnie Fong, Jan Kosla, Enrico Focaccia, Xin Li, Suhail Yousuf, Tjeerd Sijmonsma, Mohammad Rahbari, Katharina S. Kommoss, Adrian Billeter, Sandra Prokosch, Ulrike Rothermel, Florian Mueller, Jenny Hetzer, Danijela Heide, Benjamin Schinkel, Tim Machauer, Bernd Pichler, Nisar P. Malek, Thomas Longerich, Susanne Roth, Adam J. Rose, Johannes Schwenck, Christoph Trautwein, Mohammad M. Karimi, Mathias Heikenwalder
Published in: Cell Metabolism, Issue 36, 2024, ISSN 1550-4131
Publisher: Elsevier BV
DOI: 10.1016/J.CMET.2024.04.015

Single-cell multiomics reveals the interplay of clonal evolution and cellular plasticity in hepatoblastoma

Author(s): Amélie Roehrig, Theo Z. Hirsch, Aurore Pire, Guillaume Morcrette, Barkha Gupta, Charles Marcaillou, Sandrine Imbeaud, Christophe Chardot, Emmanuel Gonzales, Emmanuel Jacquemin, Masahiro Sekiguchi, Junko Takita, Genta Nagae, Eiso Hiyama, Florent Guérin, Monique Fabre, Isabelle Aerts, Sophie Taque, Véronique Laithier, Sophie Branchereau, Catherine Guettier, Laurence Brugières, Brice Fresneau, Jessica Zucman-Rossi, Eric Letouzé
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-47280-X

Single-cell RNA seq-derived signatures define response patterns to atezolizumab + bevacizumab in advanced hepatocellular carcinoma

Author(s): Sarah Cappuyns, Marta Piqué-Gili, Roger Esteban-Fabró, Gino Philips, Ugne Balaseviciute, Roser Pinyol, Albert Gris-Oliver, Vincent Vandecaveye, Jordi Abril-Fornaguera, Carla Montironi, Laia Bassaganyas, Judit Peix, Marcus Zeitlhoefler, Agavni Mesropian, Júlia Huguet-Pradell, Philipp K. Haber, Igor Figueiredo, Giorgio Ioannou, Edgar Gonzalez-Kozlova, Antonio D’Alessio, Raphael Mohr, Tim Meyer, Anja Lachenmayer, Jens U. Marquardt, Helen L. Reeves, Julien Edeline, Fabian Finkelmeier, Jörg Trojan, Peter R. Galle, Friedrich Foerster, Beatriz Mínguez, Robert Montal, Sacha Gnjatic, David J. Pinato, Mathias Heikenwalder, Chris Verslype, Eric Van Cutsem, Diether Lambrechts, Augusto Villanueva, Jeroen Dekervel, Josep M. Llovet
Published in: Journal of Hepatology, 2024, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/J.JHEP.2024.12.016

Modeling cancer–microbiome interactions in vitro: A guide to co‐culture platforms

Author(s): Kamil Moskal, Nimisha Khurana, Luisa Siegert, Ye Seul Lee, Hans Clevers, Eran Elinav, Jens Puschhof
Published in: International Journal of Cancer, Issue 156, 2025, ISSN 0020-7136
Publisher: Wiley
DOI: 10.1002/IJC.35298

Human-correlated genetic models identify precision therapy for liver cancer

Author(s): Miryam Müller, Stephanie May, Holly Hall, Timothy J. Kendall, Lynn McGarry, Lauriane Blukacz, Sandro Nuciforo, Anastasia Georgakopoulou, Thomas Jamieson, Narisa Phinichkusolchit, Sandeep Dhayade, Toshiyasu Suzuki, Júlia Huguet-Pradell, Ian R. Powley, Leah Officer-Jones, Rachel L. Pennie, Roger Esteban-Fabró, Albert Gris-Oliver, Roser Pinyol, George L. Skalka, Jack Leslie, Matthew Hoare, Joep Sprangers, Gaurav Malviya, Agata Mackintosh, Emma Johnson, Misti McCain, John Halpin, Christos Kiourtis, Colin Nixon, Graeme Clark, William Clark, Robin Shaw, Ann Hedley, Thomas M. Drake, Ee Hong Tan, Matt Neilson, Daniel J. Murphy, David Y. Lewis, Helen L. Reeves, John Le Quesne, Derek A. Mann, Leo M. Carlin, Karen Blyth, Josep M. Llovet, Markus H. Heim, Owen J. Sansom, Crispin J. Miller, Thomas G. Bird
Published in: Nature, Issue 639, 2025, ISSN 0028-0836
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41586-025-08585-Z