TUMOUR-HOST INTERACTIONS IN LIVER CANCER OF CHILDHOOD AND ADULTS

Información del proyecto

THRIVE

Identificador del acuerdo de subvención: 101136622

DOI

10.3030/101136622

Fecha de la firma de la CE 11 Diciembre 2023

Fecha de inicio 1 Diciembre 2023

Fecha de finalización 30 Noviembre 2028

Financiado con arreglo a

• Health

Coste total

€ 10 396 703,00

Aportación de la UE

€ 10 396 703,00

Coordinado por

FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (19)

HBV-related HCC development in mice is STAT3 dependent and indicates an oncogenic effect of HBx

Autores: Marc Ringelhan, Svenja Schuehle, Maarten van de Klundert, Elena Kotsiliti, Marie-Laure Plissonnier, Suzanne Faure-Dupuy, Tobias Riedl, Sebastian Lange, Karin Wisskirchen, Frank Thiele, Cho-Chin Cheng, Detian Yuan, Valentina Leone, Ronny Schmidt, Juliana Hünergard, Fabian Geisler, Kristian Unger, Hana Algül, Roland M. Schmid, Roland Rad, Heiner Wedemeyer, Massimo Levrero, Ulrike Protzer, Mathias Heikenwalder
Publicado en: JHEP Reports, Edición 6, 2024, ISSN 2589-5559
Editor: Elsevier BV
DOI: 10.1016/J.JHEPR.2024.101128

Preneoplastic liver colonization by 11p15.5 altered mosaic cells in young children with hepatoblastoma

Autores: Jill Pilet, Theo Z. Hirsch, Barkha Gupta, Amélie Roehrig, Guillaume Morcrette, Aurore Pire, Eric Letouzé, Brice Fresneau, Sophie Taque, Laurence Brugières, Sophie Branchereau, Christophe Chardot, Isabelle Aerts, Sabine Sarnacki, Monique Fabre, Catherine Guettier, Sandra Rebouissou, Jessica Zucman-Rossi
Publicado en: Nature Communications, Edición 14, 2023, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41467-023-42418-9

Ribosomal S6 kinase 1 regulates inflammaging via the senescence secretome

Autores: Suchira Gallage, Elaine E. Irvine, Jose Efren Barragan Avila, Virinder Reen, Silvia M. A. Pedroni, Imanol Duran, Vikas Ranvir, Sanjay Khadayate, Joaquim Pombo, Sharon Brookes, Danijela Heide, Gopuraja Dharmalingham, Agharul I. Choudhury, Indrabahadur Singh, Nicolás Herranz, Santiago Vernia, Mathias Heikenwalder, Jesús Gil, Dominic J. Withers
Publicado en: Nature Aging, Edición 4, 2024, ISSN 2662-8465
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S43587-024-00695-Z

Adjuvant and neoadjuvant immunotherapies in hepatocellular carcinoma

Autores: Josep M. Llovet, Roser Pinyol, Mark Yarchoan, Amit G. Singal, Thomas U. Marron, Myron Schwartz, Eli Pikarsky, Masatoshi Kudo, Richard S. Finn
Publicado en: Nature Reviews Clinical Oncology, Edición 21, 2024, ISSN 1759-4774
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41571-024-00868-0

Adjuvant and neoadjuvant immunotherapies in hepatocellular carcinoma

Autores: Josep M. Llovet, Roser Pinyol, Mark Yarchoan, Amit G. Singal, Thomas U. Marron, Myron Schwartz, Eli Pikarsky, Masatoshi Kudo, Richard S. Finn
Publicado en: Nature Reviews Clinical Oncology, Edición 21, 2024, ISSN 1759-4774
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41571-024-00868-0

Oncogenic role of PMEPA1 and its association with immune exhaustion and TGF-β activation in HCC

Autores: Marta Piqué-Gili, Carmen Andreu-Oller, Agavni Mesropian, Roger Esteban-Fabró, Marina Bárcena-Varela, Marina Ruiz de Galarreta, Carla Montironi, Iris Martinez-Quetglas, Sarah Cappuyns, Judit Peix, Ieva Keraite, Albert Gris-Oliver, Elisa Fernández-Martínez, Ezequiel Mauro, Miguel Torres-Martin, Jordi Abril-Fornaguera, Katherine E. Lindblad, Diether Lambrechts, Jeroen Dekervel, Swan N. Thung, Daniela Sia, Amaia Lujambio, Roser Pinyol, Josep M. Llovet
Publicado en: JHEP Reports, Edición 6, 2024, ISSN 2589-5559
Editor: Elsevier BV
DOI: 10.1016/J.JHEPR.2024.101212

Mutational signature, cancer driver genes mutations and transcriptomic subgroups predict HB survival.

Autores: Pire A, Hirsch TZ, … Zucman-Rossi J.
Publicado en: Eur J Cancer., Edición 200, 2024, ISSN 0346-251X
Editor: Pergamon Press Ltd.
DOI: 10.1016/J.EJCA.2024.113583.EPUB2024FEB1

Modeling cancer–microbiome interactions in vitro: A guide to co‐culture platforms

Autores: Kamil Moskal, Nimisha Khurana, Luisa Siegert, Ye Seul Lee, Hans Clevers, Eran Elinav, Jens Puschhof
Publicado en: International Journal of Cancer, 2025, ISSN 0020-7136
Editor: Wiley
DOI: 10.1002/ijc.35298

Molecular insights into early malignant transition of hepatocellular carcinoma

Autores: Zhengtao Zhang; Hong Li; Lingli Chen; Tao lu; Xinyi Shentu; Yuanhua Liu; Shuyi Ji; Zhixin Qiu; Yining Zou; Hong Wen; Jing Han; Zhengzeng Jiang; Jie Fan; Dianfan Li; Agavni Mesropian; Roser Pinyol; Josep M Llovet; Hui Dong; Yuan Ji; Lijian Hui
Publicado en: bioRxiv, 2025, ISSN 2692-8205
Editor: -
DOI: 10.1101/2025.04.14.648739

Diet-microbiome interactions in cancer

Autores: Suhaib K. Abdeen, Ignacio Mastandrea, Nina Stinchcombe, Jens Puschhof, Eran Elinav
Publicado en: Cancer Cell, Edición 43, 2025, ISSN 1535-6108
Editor: Elsevier BV
DOI: 10.1016/J.CCELL.2025.03.013

Neoadjuvant atezolizumab plus bevacizumab prior liver transplantation for hepatocellular carcinoma

Autores: Parissa Tabrizian, Rebecca Marino, Sherrie Bhoori, Marcus Zeitlhoefler, Neil Mehta, Vanessa Banz, Salvatore Gruttadauria, Massimo Iavarone, Chiara Mazzarelli, Nicolò Simonotti, Francis Yao, Vincenzo Mazzaferro, Josep M. Llovet
Publicado en: JHEP Reports, Edición 7, 2025, ISSN 2589-5559
Editor: Elsevier BV
DOI: 10.1016/J.JHEPR.2024.101246

Single-cell Profiling of Intrahepatic Immune Cells Reveals an Expansion of Tissue-resident Cytotoxic CD4+ T Lymphocyte Subset Associated With Pathogenesis of Alcoholic-associated Liver Diseases

Autores: Chao Gao, Shiguan Wang, Xiaoyu Xie, Pierluigi Ramadori, Xinying Li, Xiaoyu Liu, Xue Ding, Jinyuan Liang, Bowen Xu, Yawei Feng, Xueying Tan, Haoran Wang, Yan Zhang, Haiyan Zhang, Tingguo Zhang, Ping Mi, Shiyang Li, Cuijuan Zhang, Detian Yuan, Mathias Heikenwalder, Peng Zhang
Publicado en: Cellular and Molecular Gastroenterology and Hepatology, Edición 19, 2025, ISSN 2352-345X
Editor: Elsevier BV
DOI: 10.1016/j.jcmgh.2024.101411

Hepatocellular carcinoma hosts cholinergic neural cells and tumoral hepatocytes harboring targetable muscarinic receptors

Autores: Charlotte A. Hernandez, Claire Verzeroli, Armando Andres Roca Suarez, Abud-José Farca-Luna, Laurie Tonon, Roger Esteban-Fabró, Roser Pinyol, Marie-Laure Plissonnier, Ievgeniia Chicherova, Anaëlle Dubois, Pascale Bellaud, Marine Seffals, Bruno Turlin, Alain Fautrel, Gabriel Ichim, Michel Rivoire, Guillaume Passot, Zuzana Macek-Jilkova, Thomas Decaens, Alain Viari, Barbara Testoni, Sandra Rebouissou, Josep M. Llovet, Fabien Zoulim, Romain Parent
Publicado en: JHEP Reports, Edición 7, 2025, ISSN 2589-5559
Editor: Elsevier BV
DOI: 10.1016/J.JHEPR.2024.101245

Immune exclusion in hepatoblastoma: is β-catenin to blame again?

Autores: Theo Z. Hirsch
Publicado en: Journal of Hepatology, 2025, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/J.JHEP.2025.05.005

A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1

Autores: Suchira Gallage, Adnan Ali, Jose Efren Barragan Avila, Nogayhan Seymen, Pierluigi Ramadori, Vera Joerke, Laimdota Zizmare, David Aicher, Indresh K. Gopalsamy, Winnie Fong, Jan Kosla, Enrico Focaccia, Xin Li, Suhail Yousuf, Tjeerd Sijmonsma, Mohammad Rahbari, Katharina S. Kommoss, Adrian Billeter, Sandra Prokosch, Ulrike Rothermel, Florian Mueller, Jenny Hetzer, Danijela Heide, Benjamin Schinkel, Tim Machauer, Bernd Pichler, Nisar P. Malek, Thomas Longerich, Susanne Roth, Adam J. Rose, Johannes Schwenck, Christoph Trautwein, Mohammad M. Karimi, Mathias Heikenwalder
Publicado en: Cell Metabolism, Edición 36, 2024, ISSN 1550-4131
Editor: Elsevier BV
DOI: 10.1016/J.CMET.2024.04.015

Single-cell multiomics reveals the interplay of clonal evolution and cellular plasticity in hepatoblastoma

Autores: Amélie Roehrig, Theo Z. Hirsch, Aurore Pire, Guillaume Morcrette, Barkha Gupta, Charles Marcaillou, Sandrine Imbeaud, Christophe Chardot, Emmanuel Gonzales, Emmanuel Jacquemin, Masahiro Sekiguchi, Junko Takita, Genta Nagae, Eiso Hiyama, Florent Guérin, Monique Fabre, Isabelle Aerts, Sophie Taque, Véronique Laithier, Sophie Branchereau, Catherine Guettier, Laurence Brugières, Brice Fresneau, Jessica Zucman-Rossi, Eric Letouzé
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-47280-X

Single-cell RNA seq-derived signatures define response patterns to atezolizumab + bevacizumab in advanced hepatocellular carcinoma

Autores: Sarah Cappuyns, Marta Piqué-Gili, Roger Esteban-Fabró, Gino Philips, Ugne Balaseviciute, Roser Pinyol, Albert Gris-Oliver, Vincent Vandecaveye, Jordi Abril-Fornaguera, Carla Montironi, Laia Bassaganyas, Judit Peix, Marcus Zeitlhoefler, Agavni Mesropian, Júlia Huguet-Pradell, Philipp K. Haber, Igor Figueiredo, Giorgio Ioannou, Edgar Gonzalez-Kozlova, Antonio D’Alessio, Raphael Mohr, Tim Meyer, Anja Lachenmayer, Jens U. Marquardt, Helen L. Reeves, Julien Edeline, Fabian Finkelmeier, Jörg Trojan, Peter R. Galle, Friedrich Foerster, Beatriz Mínguez, Robert Montal, Sacha Gnjatic, David J. Pinato, Mathias Heikenwalder, Chris Verslype, Eric Van Cutsem, Diether Lambrechts, Augusto Villanueva, Jeroen Dekervel, Josep M. Llovet
Publicado en: Journal of Hepatology, 2024, ISSN 0168-8278
Editor: Elsevier BV
DOI: 10.1016/J.JHEP.2024.12.016

Modeling cancer–microbiome interactions in vitro: A guide to co‐culture platforms

Autores: Kamil Moskal, Nimisha Khurana, Luisa Siegert, Ye Seul Lee, Hans Clevers, Eran Elinav, Jens Puschhof
Publicado en: International Journal of Cancer, Edición 156, 2025, ISSN 0020-7136
Editor: Wiley
DOI: 10.1002/IJC.35298

Human-correlated genetic models identify precision therapy for liver cancer

Autores: Miryam Müller, Stephanie May, Holly Hall, Timothy J. Kendall, Lynn McGarry, Lauriane Blukacz, Sandro Nuciforo, Anastasia Georgakopoulou, Thomas Jamieson, Narisa Phinichkusolchit, Sandeep Dhayade, Toshiyasu Suzuki, Júlia Huguet-Pradell, Ian R. Powley, Leah Officer-Jones, Rachel L. Pennie, Roger Esteban-Fabró, Albert Gris-Oliver, Roser Pinyol, George L. Skalka, Jack Leslie, Matthew Hoare, Joep Sprangers, Gaurav Malviya, Agata Mackintosh, Emma Johnson, Misti McCain, John Halpin, Christos Kiourtis, Colin Nixon, Graeme Clark, William Clark, Robin Shaw, Ann Hedley, Thomas M. Drake, Ee Hong Tan, Matt Neilson, Daniel J. Murphy, David Y. Lewis, Helen L. Reeves, John Le Quesne, Derek A. Mann, Leo M. Carlin, Karen Blyth, Josep M. Llovet, Markus H. Heim, Owen J. Sansom, Crispin J. Miller, Thomas G. Bird
Publicado en: Nature, Edición 639, 2025, ISSN 0028-0836
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41586-025-08585-Z