Well-being improvement through the Integration of healthcare and reSearch Data and models with Out border for chronic iMmune-mediated diseases

Deliverables

Study recruitment report RISK-MS
Report on KPIs baselines

Project website
First press release and 2D Video presentation

Publications

Leveraging network motifs to improve artificial neural networks

Author(s): Haoling Zhang, Chao-Han Huck Yang, Hector Zenil, Pin-Yu Chen, Yue Shen, Narsis A. Kiani, Jesper N. Tegnér
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-66533-X

Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis

Author(s): Olivia G. Thomas, Urszula Rykaczewska, Marina Galešić, Rianne T.M. van der Burgt, Nils Hallén, Filippo Ferro, Mattias Bronge, Zoe Marti, Yue Li, Alexandra Hill Riqué, Jianing Lin, Aleksa Krstic, Alicja Gromadzka, András Levente Szonder, Chiara Sorini, María Reina-Campos, Ting Sun, Leslie A. Rubio Rodríguez-Kirby, Özge Dumral, Rasmus Berglund, Majid Pahlevan Kakhki, Milena Z. Adzemovic, Manuel Zeitelhofer, Birce Akpinar, Katarina Tengvall, Ola B. Nilsson, Erik Holmgren, Chiara Starvaggi Cucuzza, Klara Asplund Högelin, Guro Gafvelin, Katharina Fink, Gonçalo Castelo-Branco, Maria Needhamsen, Mohsen Khademi, Fredrik Piehl, Torbjörn Gräslund, Lars Alfredsson, Harald Lund, Per Uhlén, Ingrid Kockum, Roland Martin, Maja Jagodic, Hans Grönlund, André Ortlieb Guerreiro-Cacais, Tomas Olsson
Published in: Cell, Issue 189, 2026, ISSN 0092-8674
Publisher: Elsevier BV
DOI: 10.1016/J.CELL.2025.12.032

Early comorbidities and diagnostic challenges in people with multiple sclerosis with possible impact on disease management

Author(s): Christine Makarov, Ewan Donnachie, Alexander Hapfelmeier, Bernhard Hemmer, Christiane Gasperi
Published in: Multiple Sclerosis Journal - Experimental, Translational and Clinical, Issue 11, 2025, ISSN 2055-2173
Publisher: SAGE Publications
DOI: 10.1177/20552173251315458

Multiple Sclerosis

Author(s): Sonia Darvishi; Ewan Donnachie; Christiane Gasperi; Alexander Hapfelmeier; Bernhard Hemmer
Published in: Multiple Sclerosis Journal, 2024, ISSN 1352-4585
Publisher: Sage
DOI: 10.1177/13524585241297003

Antibody reactivity against EBNA1 and GlialCAM differentiates multiple sclerosis patients from healthy controls

Author(s): Neda Sattarnezhad; Ingrid Kockum; Olivia G. Thomas; Yicong Liu; Peggy P. Ho; Alison K. Barrett; Alexandros I. Comanescu; Tilini U. Wijeratne; Paul J. Utz; Lars Alfredsson; Lawrence Steinman; William H. Robinson; Tomas Olsson; Tobias V. Lanz
Published in: Proceedings of the National Academy of Sciences, 2025, ISSN 1091-6490
Publisher: the National Academy of Sciences (NAS)
DOI: 10.1073/PNAS.2424986122

Multiomics integration prioritizes potential drug targets for multiple sclerosis

Author(s): Yuan Jiang, Qianwen Liu, Pernilla Stridh, Ingrid Kockum, Tomas Olsson, Lars Alfredsson, Lina-Marcela Diaz-Gallo, Xia Jiang
Published in: Proceedings of the National Academy of Sciences, Issue 122, 2025, ISSN 0027-8424
Publisher: Proceedings of the National Academy of Sciences
DOI: 10.1073/PNAS.2425537122

Seropositivity against rubella virus envelope protein 1, but not 2, is associated with an increased risk of multiple sclerosis

Author(s): Jens Ingvarsson, Viktor Grut, Martin Biström, Linn Persson Berg, Julia Butt, Birgitta Michels, Pernilla Stridh, Tomas Olsson, Lars Alfredsson, Ingrid Kockum, Tim Waterboer, Staffan Nilsson, Peter Sundström
Published in: Clinical & Translational Immunology, Issue 15, 2026, ISSN 2050-0068
Publisher: Wiley
DOI: 10.1002/CTI2.70094

Prospective study validating a multidimensional treatment decision score predicting the 24-month outcome in untreated patients with clinically isolated syndrome and early relapsing–remitting multiple sclerosis, the ProVal-MS study

Author(s): Antonios Bayas, Ulrich Mansmann, Begum Irmak Ön, Verena S. Hoffmann, Achim Berthele, Mark Mühlau, Markus C. Kowarik, Markus Krumbholz, Makbule Senel, Verena Steuerwald, Markus Naumann, Julia Hartberger, Martin Kerschensteiner, Eva Oswald, Christoph Ruschil, Ulf Ziemann, Hayrettin Tumani, Ioannis Vardakas, Fady Albashiti, Frank Kramer, Iñaki Soto-Rey, Helmut Spengler, Gerhard Mayer, Hans Armin Kestler, Oliver Kohlbacher, Marlien Hagedorn, Martin Boeker, Klaus Kuhn, Stefan Buchka, Florian Kohlmayer, Jan S. Kirschke, Lars Behrens, Hanna Zimmermann, Benjamin Bender, Nico Sollmann, Joachim Havla, Bernhard Hemmer, null null, Ansgar Berlis, Benedikt Wiestler, Tania Kümpfel, Klaus Seelos, Jutta Dünschede, Roswitha Kemmner, Meinrad Beer, Jennifer Dietrich, Jonas Schaller
Published in: Neurological Research and Practice, Issue 6, 2024, ISSN 2524-3489
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S42466-024-00310-X

Pharmacogenomics of response to interferon-beta and glatiramer acetate in Multiple Sclerosis: A multi-centric study

Author(s): Andrea Corona, Ferdinando Clarelli, Kimmo Pääkkönen, Adil Harroud, Klementy Shchetynsky, Alen Zollo, Alessandra Mingione, Melissa Sorosina, Elisabetta Mascia, Antonino Giordano, Maria Assunta Rocca, Fredrik Piehl, Pernilla Stridh, Bernhard Hemmer, An Goris, Bénédicte Dubois, Helle Bach Søndergaard, Finn Sellebjerg, Sandra D’alfonso, Hanne Flinstad Harbo, Tomas Olsson, Janna Saarela, Alberto Priori, Massimo Filippi, Ingrid Kockum, Federica Esposito, Filippo Martinelli Boneschi
Published in: Multiple Sclerosis Journal, Issue 32, 2026, ISSN 1352-4585
Publisher: SAGE Publications
DOI: 10.1177/13524585261417130

Neurofilament light chain as a surrogate candidate for disease activity in multiple sclerosis (LUMINOUS)—A meta-regression of randomized controlled trials

Author(s): Roxanne Pretzsch, Sahla El Mahdaoui, Poljanka Johnson, Mafalda Delgado Soares, Kimberly Koerbel, Friederike Held, Albulena Bajrami, Valeria Pozzilli, Matteo Lucchini, Elena Barbuti, Frederik Bartels, Robert Barket, Christian Cordano, Bernhard Hemmer, Alessandro Cagol, Irene Schiavetti, Maria Pia Sormani, null null
Published in: Multiple Sclerosis Journal, Issue 32, 2026, ISSN 1352-4585
Publisher: SAGE Publications
DOI: 10.1177/13524585251407973

A susceptibility network analysis of disease trajectories leading to multiple sclerosis: A nationwide cohort study

Author(s): Ali Ebrahimi, Uffe Kock Wiil, Tomas Olsson, Pietro Liò, Ingrid Kockum, Ali Manouchehrinia, Narsis A Kiani
Published in: Multiple Sclerosis Journal, Issue 32, 2026, ISSN 1352-4585
Publisher: SAGE Publications
DOI: 10.1177/13524585261421480

Multi-omics integration provides biological insight and prioritizes potential drug targets in multiple sclerosis progression

Author(s): Yuan Jiang, Jinyu Xiao, Ingrid Kockum, Pernilla Stridh, Qianwen Liu, Tomas Olsson, Lars Alfredsson, Xia Jiang
Published in: Journal of Neuroinflammation, Issue 23, 2026, ISSN 1742-2094
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S12974-026-03895-Z

Real-world practices and challenges of radiologically isolated syndrome: results of a cross-sector survey by the DACH MS guidelines group

Author(s): Friederike Held, Antonios Bayas, Katharina Christe, Christian Dettmers, Burkhard Domurath, Juliane Ebert, Edeltraud Faßhauer, Peter Flachenecker, Jutta Gärtner, Dzenita Hasanbasic, Christoph Heesen, Harald Hegen, Thomas Henze, Peter Huppke, Veronika Kana, Michael Khalil, Ruth Kirschner-Hermanns, Thomas Korn, Tania Kümpfel, Sabine Lamprecht, Uwe Meier, Gerd Meyer zu Horste, Mathias Mäurer, Frederike Cosima Oertel, Caroline Pot, Anne-Katrin Pröbstel, Kevin Rostásy, Anke Salmen, Jutta Scheiderbauer, Markus Schmidt, Erwin Stark, Corinna Trebst, Regina Trollmann, Clemens Warnke, Mike P. Wattjes, Benedikt Wiestler, Brigitte Wildemann, Uwe Zimmermann, Klaus Gehring, Achim Berthele, Bernhard Hemmer
Published in: Frontiers in Neurology, Issue 17, 2026, ISSN 1664-2295
Publisher: Frontiers Media SA
DOI: 10.3389/FNEUR.2026.1822692

Single Cell Analysis of Cerebrospinal Fluid Reveals Common Features of Neuroinflammation

Author(s): Jacobs, Benjamin M; Gasperi, Christiane; Kalluri, Sudhakar Reddy; Al-Najjar, Raghda; McKeon, Mollie O; Else, Jonathan; Pukaj, Albert; Held, Friederike; Sawcer, Stephen; Ban, Maria; Hemmer, Bernhard
Published in: Cell Reports Medicine, 2023, ISSN 2666-3791
Publisher: Cell press
DOI: 10.1016/J.XCRM.2024.101733

LEP-AD: language embedding of proteins and attention to drugs predicts drug-target interactions

Author(s): Reem Alsulami, Robert Lehmann, Anuj Daga, Sumeer A. Khan, Raik Grünberg, Ahmed Abogosh, David Gomez Cabrero, Stefan T. Arold, Robert Hoehndorf, Jesper Tegner, Narsis A. Kiani
Published in: Journal of Cheminformatics, Issue 18, 2026, ISSN 1758-2946
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13321-026-01167-9

Depression Polygenicity and Disease Activity and Disability Worsening in Multiple Sclerosis

Author(s): Ali Manouchehrinia, Kathryn C. Fitzgerald, Amber Salter, Ruth Ann Marrie, Lars Alfredsson, Charles N. Bernstein, James M. Bolton, Gary Cutter, John D. Fisk, Lesley A. Graff, Carol A. Hitchon, Jan Hillert, Ingrid Kockum, Yi Lu, Fred D. Lublin, Kyla McKay, Tomas Olsson, Scott Patten, Amit Patki, Hayley Riel, Klementy Shchetynsky, Pernilla Stridh, Hemant K. Tiwari, Jerry S. Wolinsky, Kaarina Kowalec
Published in: Annals of Neurology, 2025, ISSN 0364-5134
Publisher: Wiley
DOI: 10.1002/ANA.70020

Multiple Sclerosis and Related Disorders

Author(s): Sonia Darvishi; Ewan Donnachie; Paula Anne Uibel; Martina Flaskamp; Christiane Gasperi; Alexander Hapfelmeier; Bernhard Hemmer
Published in: Multiple Sclerosis and Related Disorders, 2025, ISSN 2211-0348
Publisher: Elsevier
DOI: 10.1016/J.MSARD.2025.106366

Large-scale proteomics across neurological disorders uncovers biomarker panel and targets in multiple sclerosis

Author(s): Jakob Maximilian Bader, Christine Makarov, Sabrina Richter, Maximilian Thomas Strauss, Friederike Held, Maria Wahle, Michael Baggio Lorenz, Lara Pöschl, Patricia Skowronek, Marvin Thielert, Achim Berthele, Wen-Feng Zeng, Constantin Ammar, Isabell Bludau, Benjamin Schubert, Fabian J. Theis, Christiane Gasperi, Bernhard Hemmer, Matthias Mann
Published in: Cell, Issue 189, 2026, ISSN 0092-8674
Publisher: Elsevier BV
DOI: 10.1016/J.CELL.2026.01.017

Nicotine, Alcohol Consumption, and Risk of Myasthenia Gravis

Author(s): Malin Petersson, Daniel Jons, Amalia Feresiadou, Andreea Ilinca, Fredrik Lundin, Rune Johansson, Anna Budzianowska, Anna-Karin Roos, Viktor Kagstrom, Martin Gunnarsson, Peter Sundström, Lars Klareskog, Tomas Olsson, Ingrid Kockum, Fredrik Piehl, Lars Alfredsson, Susanna Brauner
Published in: Neurology, Issue 105, 2025, ISSN 0028-3878
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1212/WNL.0000000000213771

Predicting and interpreting cell-type-specific drug responses in the small-data regime using inductive priors

Author(s): Reem Alsulami, Robert Lehmann, Sumeer A. Khan, Vincenzo Lagani, Alberto Maillo, David Gomez-Cabrero, Narsis A. Kiani, Jesper Tegner
Published in: Nature Machine Intelligence, Issue 8, 2026, ISSN 2522-5839
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S42256-026-01202-2

Proteomics Reveals Age as Major Modifier of Inflammatory CSF Signatures in Multiple Sclerosis

Author(s): Friederike Held, Christine Makarov, Christiane Gasperi, Martina Flaskamp, Verena Grummel, Achim Berthele, Bernhard Hemmer
Published in: Neurology Neuroimmunology & Neuroinflammation, Issue 12, 2025, ISSN 2332-7812
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1212/NXI.0000000000200322

Co-exposure to PFAS and hydroxylated PCBs is associated with increased odds of multiple sclerosis

Author(s): Aina Vaivade, Akshai Parakkal Sreenivasan, Ida Erngren, Eva Freyhult, Payam Emami Khoonsari, Jakob Siljebo, Asma Al-Grety, Henrik Carlsson, Torbjörn Åkerfeldt, Ola Spjuth, Anna Karin Hedström, Ingrid Kockum, Lars Alfredsson, Tomas Olsson, Joachim Burman, Kim Kultima
Published in: Environment International, Issue 207, 2026, ISSN 0160-4120
Publisher: Elsevier BV
DOI: 10.1016/J.ENVINT.2025.109993

For AI in medicine, there is one thing on which all patients agree: Not without my (human) doctor

Author(s): Amanda Shapiro & Mette Hartlev
Published in: WISDOM Blog post for audience of scholars, patient advocates, and policy-makers, 2025
Publisher: https://wisdomhorizon.eu/blog

Project Results

Deliverables

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