Well-being improvement through the Integration of healthcare and reSearch Data and models with Out border for chronic iMmune-mediated diseases

Informazioni relative al progetto

WISDOM

ID dell’accordo di sovvenzione: 101137154

DOI

10.3030/101137154

Data della firma CE 23 Novembre 2023

Data di avvio 1 Dicembre 2023

Data di completamento 30 Novembre 2028

Finanziato da

• Health

Costo totale

€ 9 598 516,50

Contributo UE

€ 9 598 516,50

Coordinato da

KAROLINSKA INSTITUTET
Sweden

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (2)

Study recruitment report RISK-MS
Report on KPIs baselines

Websites, patent fillings, videos etc. (2)

Project website
First press release and 2D Video presentation

Pubblicazioni

Peer reviewed articles (22)

Leveraging network motifs to improve artificial neural networks

Autori: Haoling Zhang, Chao-Han Huck Yang, Hector Zenil, Pin-Yu Chen, Yue Shen, Narsis A. Kiani, Jesper N. Tegnér
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-66533-X

Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis

Autori: Olivia G. Thomas, Urszula Rykaczewska, Marina Galešić, Rianne T.M. van der Burgt, Nils Hallén, Filippo Ferro, Mattias Bronge, Zoe Marti, Yue Li, Alexandra Hill Riqué, Jianing Lin, Aleksa Krstic, Alicja Gromadzka, András Levente Szonder, Chiara Sorini, María Reina-Campos, Ting Sun, Leslie A. Rubio Rodríguez-Kirby, Özge Dumral, Rasmus Berglund, Majid Pahlevan Kakhki, Milena Z. Adzemovic, Manuel Zeitelhofer, Birce Akpinar, Katarina Tengvall, Ola B. Nilsson, Erik Holmgren, Chiara Starvaggi Cucuzza, Klara Asplund Högelin, Guro Gafvelin, Katharina Fink, Gonçalo Castelo-Branco, Maria Needhamsen, Mohsen Khademi, Fredrik Piehl, Torbjörn Gräslund, Lars Alfredsson, Harald Lund, Per Uhlén, Ingrid Kockum, Roland Martin, Maja Jagodic, Hans Grönlund, André Ortlieb Guerreiro-Cacais, Tomas Olsson
Pubblicato in: Cell, Numero 189, 2026, ISSN 0092-8674
Editore: Elsevier BV
DOI: 10.1016/J.CELL.2025.12.032

Early comorbidities and diagnostic challenges in people with multiple sclerosis with possible impact on disease management

Autori: Christine Makarov, Ewan Donnachie, Alexander Hapfelmeier, Bernhard Hemmer, Christiane Gasperi
Pubblicato in: Multiple Sclerosis Journal - Experimental, Translational and Clinical, Numero 11, 2025, ISSN 2055-2173
Editore: SAGE Publications
DOI: 10.1177/20552173251315458

Multiple Sclerosis

Autori: Sonia Darvishi; Ewan Donnachie; Christiane Gasperi; Alexander Hapfelmeier; Bernhard Hemmer
Pubblicato in: Multiple Sclerosis Journal, 2024, ISSN 1352-4585
Editore: Sage
DOI: 10.1177/13524585241297003

Antibody reactivity against EBNA1 and GlialCAM differentiates multiple sclerosis patients from healthy controls

Autori: Neda Sattarnezhad; Ingrid Kockum; Olivia G. Thomas; Yicong Liu; Peggy P. Ho; Alison K. Barrett; Alexandros I. Comanescu; Tilini U. Wijeratne; Paul J. Utz; Lars Alfredsson; Lawrence Steinman; William H. Robinson; Tomas Olsson; Tobias V. Lanz
Pubblicato in: Proceedings of the National Academy of Sciences, 2025, ISSN 1091-6490
Editore: the National Academy of Sciences (NAS)
DOI: 10.1073/PNAS.2424986122

Multiomics integration prioritizes potential drug targets for multiple sclerosis

Autori: Yuan Jiang, Qianwen Liu, Pernilla Stridh, Ingrid Kockum, Tomas Olsson, Lars Alfredsson, Lina-Marcela Diaz-Gallo, Xia Jiang
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 122, 2025, ISSN 0027-8424
Editore: Proceedings of the National Academy of Sciences
DOI: 10.1073/PNAS.2425537122

Seropositivity against rubella virus envelope protein 1, but not 2, is associated with an increased risk of multiple sclerosis

Autori: Jens Ingvarsson, Viktor Grut, Martin Biström, Linn Persson Berg, Julia Butt, Birgitta Michels, Pernilla Stridh, Tomas Olsson, Lars Alfredsson, Ingrid Kockum, Tim Waterboer, Staffan Nilsson, Peter Sundström
Pubblicato in: Clinical & Translational Immunology, Numero 15, 2026, ISSN 2050-0068
Editore: Wiley
DOI: 10.1002/CTI2.70094

Prospective study validating a multidimensional treatment decision score predicting the 24-month outcome in untreated patients with clinically isolated syndrome and early relapsing–remitting multiple sclerosis, the ProVal-MS study

Autori: Antonios Bayas, Ulrich Mansmann, Begum Irmak Ön, Verena S. Hoffmann, Achim Berthele, Mark Mühlau, Markus C. Kowarik, Markus Krumbholz, Makbule Senel, Verena Steuerwald, Markus Naumann, Julia Hartberger, Martin Kerschensteiner, Eva Oswald, Christoph Ruschil, Ulf Ziemann, Hayrettin Tumani, Ioannis Vardakas, Fady Albashiti, Frank Kramer, Iñaki Soto-Rey, Helmut Spengler, Gerhard Mayer, Hans Armin Kestler, Oliver Kohlbacher, Marlien Hagedorn, Martin Boeker, Klaus Kuhn, Stefan Buchka, Florian Kohlmayer, Jan S. Kirschke, Lars Behrens, Hanna Zimmermann, Benjamin Bender, Nico Sollmann, Joachim Havla, Bernhard Hemmer, null null, Ansgar Berlis, Benedikt Wiestler, Tania Kümpfel, Klaus Seelos, Jutta Dünschede, Roswitha Kemmner, Meinrad Beer, Jennifer Dietrich, Jonas Schaller
Pubblicato in: Neurological Research and Practice, Numero 6, 2024, ISSN 2524-3489
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S42466-024-00310-X

Pharmacogenomics of response to interferon-beta and glatiramer acetate in Multiple Sclerosis: A multi-centric study

Autori: Andrea Corona, Ferdinando Clarelli, Kimmo Pääkkönen, Adil Harroud, Klementy Shchetynsky, Alen Zollo, Alessandra Mingione, Melissa Sorosina, Elisabetta Mascia, Antonino Giordano, Maria Assunta Rocca, Fredrik Piehl, Pernilla Stridh, Bernhard Hemmer, An Goris, Bénédicte Dubois, Helle Bach Søndergaard, Finn Sellebjerg, Sandra D’alfonso, Hanne Flinstad Harbo, Tomas Olsson, Janna Saarela, Alberto Priori, Massimo Filippi, Ingrid Kockum, Federica Esposito, Filippo Martinelli Boneschi
Pubblicato in: Multiple Sclerosis Journal, Numero 32, 2026, ISSN 1352-4585
Editore: SAGE Publications
DOI: 10.1177/13524585261417130

Neurofilament light chain as a surrogate candidate for disease activity in multiple sclerosis (LUMINOUS)—A meta-regression of randomized controlled trials

Autori: Roxanne Pretzsch, Sahla El Mahdaoui, Poljanka Johnson, Mafalda Delgado Soares, Kimberly Koerbel, Friederike Held, Albulena Bajrami, Valeria Pozzilli, Matteo Lucchini, Elena Barbuti, Frederik Bartels, Robert Barket, Christian Cordano, Bernhard Hemmer, Alessandro Cagol, Irene Schiavetti, Maria Pia Sormani, null null
Pubblicato in: Multiple Sclerosis Journal, Numero 32, 2026, ISSN 1352-4585
Editore: SAGE Publications
DOI: 10.1177/13524585251407973

A susceptibility network analysis of disease trajectories leading to multiple sclerosis: A nationwide cohort study

Autori: Ali Ebrahimi, Uffe Kock Wiil, Tomas Olsson, Pietro Liò, Ingrid Kockum, Ali Manouchehrinia, Narsis A Kiani
Pubblicato in: Multiple Sclerosis Journal, Numero 32, 2026, ISSN 1352-4585
Editore: SAGE Publications
DOI: 10.1177/13524585261421480

Multi-omics integration provides biological insight and prioritizes potential drug targets in multiple sclerosis progression

Autori: Yuan Jiang, Jinyu Xiao, Ingrid Kockum, Pernilla Stridh, Qianwen Liu, Tomas Olsson, Lars Alfredsson, Xia Jiang
Pubblicato in: Journal of Neuroinflammation, Numero 23, 2026, ISSN 1742-2094
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S12974-026-03895-Z

Real-world practices and challenges of radiologically isolated syndrome: results of a cross-sector survey by the DACH MS guidelines group

Autori: Friederike Held, Antonios Bayas, Katharina Christe, Christian Dettmers, Burkhard Domurath, Juliane Ebert, Edeltraud Faßhauer, Peter Flachenecker, Jutta Gärtner, Dzenita Hasanbasic, Christoph Heesen, Harald Hegen, Thomas Henze, Peter Huppke, Veronika Kana, Michael Khalil, Ruth Kirschner-Hermanns, Thomas Korn, Tania Kümpfel, Sabine Lamprecht, Uwe Meier, Gerd Meyer zu Horste, Mathias Mäurer, Frederike Cosima Oertel, Caroline Pot, Anne-Katrin Pröbstel, Kevin Rostásy, Anke Salmen, Jutta Scheiderbauer, Markus Schmidt, Erwin Stark, Corinna Trebst, Regina Trollmann, Clemens Warnke, Mike P. Wattjes, Benedikt Wiestler, Brigitte Wildemann, Uwe Zimmermann, Klaus Gehring, Achim Berthele, Bernhard Hemmer
Pubblicato in: Frontiers in Neurology, Numero 17, 2026, ISSN 1664-2295
Editore: Frontiers Media SA
DOI: 10.3389/FNEUR.2026.1822692

Single Cell Analysis of Cerebrospinal Fluid Reveals Common Features of Neuroinflammation

Autori: Jacobs, Benjamin M; Gasperi, Christiane; Kalluri, Sudhakar Reddy; Al-Najjar, Raghda; McKeon, Mollie O; Else, Jonathan; Pukaj, Albert; Held, Friederike; Sawcer, Stephen; Ban, Maria; Hemmer, Bernhard
Pubblicato in: Cell Reports Medicine, 2023, ISSN 2666-3791
Editore: Cell press
DOI: 10.1016/J.XCRM.2024.101733

LEP-AD: language embedding of proteins and attention to drugs predicts drug-target interactions

Autori: Reem Alsulami, Robert Lehmann, Anuj Daga, Sumeer A. Khan, Raik Grünberg, Ahmed Abogosh, David Gomez Cabrero, Stefan T. Arold, Robert Hoehndorf, Jesper Tegner, Narsis A. Kiani
Pubblicato in: Journal of Cheminformatics, Numero 18, 2026, ISSN 1758-2946
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S13321-026-01167-9

Depression Polygenicity and Disease Activity and Disability Worsening in Multiple Sclerosis

Autori: Ali Manouchehrinia, Kathryn C. Fitzgerald, Amber Salter, Ruth Ann Marrie, Lars Alfredsson, Charles N. Bernstein, James M. Bolton, Gary Cutter, John D. Fisk, Lesley A. Graff, Carol A. Hitchon, Jan Hillert, Ingrid Kockum, Yi Lu, Fred D. Lublin, Kyla McKay, Tomas Olsson, Scott Patten, Amit Patki, Hayley Riel, Klementy Shchetynsky, Pernilla Stridh, Hemant K. Tiwari, Jerry S. Wolinsky, Kaarina Kowalec
Pubblicato in: Annals of Neurology, 2025, ISSN 0364-5134
Editore: Wiley
DOI: 10.1002/ANA.70020

Multiple Sclerosis and Related Disorders

Autori: Sonia Darvishi; Ewan Donnachie; Paula Anne Uibel; Martina Flaskamp; Christiane Gasperi; Alexander Hapfelmeier; Bernhard Hemmer
Pubblicato in: Multiple Sclerosis and Related Disorders, 2025, ISSN 2211-0348
Editore: Elsevier
DOI: 10.1016/J.MSARD.2025.106366

Large-scale proteomics across neurological disorders uncovers biomarker panel and targets in multiple sclerosis

Autori: Jakob Maximilian Bader, Christine Makarov, Sabrina Richter, Maximilian Thomas Strauss, Friederike Held, Maria Wahle, Michael Baggio Lorenz, Lara Pöschl, Patricia Skowronek, Marvin Thielert, Achim Berthele, Wen-Feng Zeng, Constantin Ammar, Isabell Bludau, Benjamin Schubert, Fabian J. Theis, Christiane Gasperi, Bernhard Hemmer, Matthias Mann
Pubblicato in: Cell, Numero 189, 2026, ISSN 0092-8674
Editore: Elsevier BV
DOI: 10.1016/J.CELL.2026.01.017

Nicotine, Alcohol Consumption, and Risk of Myasthenia Gravis

Autori: Malin Petersson, Daniel Jons, Amalia Feresiadou, Andreea Ilinca, Fredrik Lundin, Rune Johansson, Anna Budzianowska, Anna-Karin Roos, Viktor Kagstrom, Martin Gunnarsson, Peter Sundström, Lars Klareskog, Tomas Olsson, Ingrid Kockum, Fredrik Piehl, Lars Alfredsson, Susanna Brauner
Pubblicato in: Neurology, Numero 105, 2025, ISSN 0028-3878
Editore: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1212/WNL.0000000000213771

Predicting and interpreting cell-type-specific drug responses in the small-data regime using inductive priors

Autori: Reem Alsulami, Robert Lehmann, Sumeer A. Khan, Vincenzo Lagani, Alberto Maillo, David Gomez-Cabrero, Narsis A. Kiani, Jesper Tegner
Pubblicato in: Nature Machine Intelligence, Numero 8, 2026, ISSN 2522-5839
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S42256-026-01202-2

Proteomics Reveals Age as Major Modifier of Inflammatory CSF Signatures in Multiple Sclerosis

Autori: Friederike Held, Christine Makarov, Christiane Gasperi, Martina Flaskamp, Verena Grummel, Achim Berthele, Bernhard Hemmer
Pubblicato in: Neurology Neuroimmunology & Neuroinflammation, Numero 12, 2025, ISSN 2332-7812
Editore: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1212/NXI.0000000000200322

Co-exposure to PFAS and hydroxylated PCBs is associated with increased odds of multiple sclerosis

Autori: Aina Vaivade, Akshai Parakkal Sreenivasan, Ida Erngren, Eva Freyhult, Payam Emami Khoonsari, Jakob Siljebo, Asma Al-Grety, Henrik Carlsson, Torbjörn Åkerfeldt, Ola Spjuth, Anna Karin Hedström, Ingrid Kockum, Lars Alfredsson, Tomas Olsson, Joachim Burman, Kim Kultima
Pubblicato in: Environment International, Numero 207, 2026, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2025.109993

Other (1)

For AI in medicine, there is one thing on which all patients agree: Not without my (human) doctor

Autori: Amanda Shapiro & Mette Hartlev
Pubblicato in: WISDOM Blog post for audience of scholars, patient advocates, and policy-makers, 2025
Editore: https://wisdomhorizon.eu/blog