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A federated paradigm of real-world data sources utilization for the empowerment of diagnosis, prognosis and risk assessment of cardiovascular conditions

Project description

Revolutionising cardiovascular health, one link at a time

Each year, over 6 million new cases of cardiovascular disease (CVD) plague the EU, claiming 1.8 million lives and straining healthcare systems. The lack of effective preventive interventions exacerbates this crisis, burdening both patients and society. In this context, the EU-funded CVDLINK project aims to harness a privacy-by-design European-wide federated platform. It aims to integrate disparate data sources, offering personalised interventions. Specifically, CVDLINK integrates diverse data sources securely, enabling tailored interventions. It offers AI-driven precision medicine tools for diagnosis and treatment, addressing seven cardiovascular conditions across seven countries. Prospectively validated in five nations, CVDLINK promises significant benefits for health systems and citizens. With best practices and cost-effectiveness analyses, it aims for widespread adoption, heralding a new era in CVD care and prevention.

Objective

In the EU more than 6 million new cardiovascular disease (CVD) cases are reported yearly, along with 1.8 million related deaths, posing a substantial burden on the national healthcare systems and society in general. Development of effective preventive interventions, adopted for each individual and population, will not only reduce the overall cost of patient management, but will also justify the assertion that CVDs could be ultimately prevented and controlled. The exploration of existing clinical, genetic and real-world data sources can contribute to this direction, however several challenges related to the data availability, management and processing remain open.
The 48-month project CVDLINK aims to tackle these challenges by implementing a privacy-by-design European-wide federated platform-as-a-service (PaaS) for the delivery of effective data-driven human-centric interventions and the advancement of research and management in the CVD domain. CVDLINK is based on two major offerings: (1) the seamless and legally compliant linking and integration, secure sharing and automated curation of existing data; and (2) a set of AI and data-enabled precision medicine tools and pipelines, for better diagnosis, risk stratification and treatment.
In the context of the project, 7 different cardiovascular conditions will be examined, making use of different retrospective datasets, cohort studies and biobanks from 7 counties, aiming to set a paradigm of the how heterogeneous data sources, can be effectively exploited for building comprehensive AI-driven tools, in order to bring substantial benefits for health systems, patients, industry and EU citizens. The developed tools will be prospectively validated in 5 countries, demonstrating the impact of CVDLINK. Additionally, a set of best practices will be generated, which along with a cost-effectiveness analysis, and systematic raising awareness campaigns will promote its wide adoption in the mid-term.

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Programme(s)

Topic(s)

Funding Scheme

HORIZON-RIA - HORIZON Research and Innovation Actions

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Call for proposal

(opens in new window) HORIZON-HLTH-2023-TOOL-05

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Coordinator

SOFTWARE IMAGINATION AND VISION SRL
Net EU contribution
€ 928 750,00
Address
SOSEAUA BUCURESTI-PLOIESTI 73-81 COMPLEX VICTORIA PARK CORP CLADIRE C4 PARTER ZONA B
013685 BUCURESTI
Romania
SME
Yes
Region
Macroregiunea Trei Bucureşti-Ilfov Bucureşti
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
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Total cost
€ 928 750,00

Participants (18)