Virtual Brain Twin for personalised treatment of Psychiatric Disorders

Project Information

VIRTUAL BRAIN TWIN

Grant agreement ID: 101137289

DOI

10.3030/101137289

EC signature date 22 November 2023

Start date 1 January 2024

End date 31 December 2027

Funded under

• Health

Total cost

€ 10 000 000,00

EU contribution

€ 10 000 000,00

Coordinated by

EBRAINS
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Project website

Establishment of a website to disseminate the activities and results of the Virtual Brain Twin Project.

Other (2)

Integrative workflows GUI – first version

Front end integrative application, with multiscale graphic tools exposed uniformly

Virtual Brain Twin software ecosystem toolset – Backend first version

The 5 deliverables for WP6 are all working towards the same end-product (a Virtual Brain Twin software ecosystem) intended to be modular (with 2 larger components: front-end and backend) and developed in an agile manner. The Back-end offers an integrating solution for wrapping multiple tools under one reusable deployment solution.

Documents, reports (3)

Report on workflows

Report for workflows bridging from the molecular to cellular/microcircuit and to point neuron levels

Initial DCE Plan

Plan for dissemination and exploitation including communication activities

Project Launch

In-person consortium meeting to kick-off the project and agree operational plans.

Publications

Peer reviewed articles (27)

Entropy and Complexity Tools Across Scales in Neuroscience: A Review

Author(s): Rodrigo Cofré, Alain Destexhe
Published in: Entropy, Issue 27, 2025, ISSN 1099-4300
Publisher: MDPI AG
DOI: 10.3390/E27020115

Would you publish unrealistic model?

Author(s): Damien Depannemaecker
Published in: Biological Cybernetics, 2024, ISSN 1432-0770
Publisher: Springer Nature
DOI: 10.1007/S00422-024-00999-8

Sharing brain imaging data in the Open Science era: how and why?

Author(s): Giehl, Kathrin; Mutsaerts, Henk-Jan; Aarts, Kristien; Barkhof, Frederik; Caspers, Svenja; Chetelat, Gaël; Colin, Marie-Elisabeth; Düzel, Emrah; Frisoni, Giovanni B; Ikram, M Arfan; Jovicich, Jorge; Morbelli, Silvia; Oertel, Wolfgang; Paret, Christian; Perani, Daniela; Ritter, Petra; Segura, Bàrbara; Wisse, Laura E M; De Witte, Elke; Cappa, Stefano F; van Eimeren, Thilo
Published in: The Lancet Digital Health, 2024, ISSN 2589-7500
Publisher: Elsevier
DOI: 10.34734/FZJ-2024-04789

Nature Communications

Author(s): Dominik P. Koller; Michael Schirner; Petra Ritter
Published in: Nature Communications, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-47860-x

Simulation-based inference on virtual brain models of disorders

Author(s): Meysam Hashemi; Abolfazl Ziaeemehr; Marmaduke M Woodman; Jan Fousek; Spase Petkoski; Viktor K Jirsa
Published in: Machine Learning: Science and Technology, 2024, ISSN 2632-2153
Publisher: IOP
DOI: 10.1088/2632-2153/AD6230

Frontiers in Cellular Neuroscience

Author(s): Pawan Faris; Doris Pischedda; Fulvia Palesi; Egidio D’Angelo; Egidio D’Angelo
Published in: Frontiers in Cellular Neuroscience, 2024, ISSN 1662-5102
Publisher: Frontiers Media
DOI: 10.3389/fncel.2024.1386583

Mapping global brain reconfigurations following local targeted manipulations

Author(s): Giovanni Rabuffo; Houefa-Armelle Lokossou; Zengmin Li; Abolfazl Ziaee-Mehr; Meysam Hashemi; Pascale P. Quilichini; Antoine Ghestem; Ouafae Arab; Monique Esclapez; Parul Verma; Ashish Raj; Alessandro Gozzi; Pierpaolo Sorrentino; Kai-Hsiang Chuang; Teodora-Adriana Perles-Barbacaru; Angèle Viola; Viktor K. Jirsa; Christophe Bernard
Published in: Proceedings of the National Academy of Sciences, 2025, ISSN 1091-6490
Publisher: National Academy of Sciences
DOI: 10.1073/PNAS.2405706122

Simulating the impact of white matter connectivity on processing time scales using brain network models

Author(s): Triebkorn, Paul; Jirsa, Viktor; Dominey, Peter
Published in: Communications Biology, 2025, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.1038/S42003-025-07587-X

The Virtual Parkinsonian Patient

Author(s): Marianna Angiolelli; Damien Depannemaecker; Hasnae Agouram; Jean Ŕegis; Romain Carron; Marmaduke Woodman; Letizia Chiodo; Paul Triebkorn; Abolfazl Ziaeemehr; Meysam Hashemi; Alexandre Eusebio; Viktor Jirsa; Pierpaolo Sorrentino
Published in: npj Systems Biology and Applications, 2025, ISSN 2056-7189
Publisher: Springer Nature
DOI: 10.1038/S41540-025-00516-Y

Frontiers in Neuroanatomy

Author(s): Ivan Velasco; Juan J. Garcia-Cantero; Juan J. Garcia-Cantero; Juan P. Brito; Juan P. Brito; Sofia Bayona; Sofia Bayona; Luis Pastor; Luis Pastor; Susana Mata; Susana Mata
Published in: Frontiers in Neuroanatomy, 2024, ISSN 1662-5129
Publisher: Frontiers Media
DOI: 10.3389/fnana.2024.1342762

The impact of Parkinson’s disease on striatal network connectivity and cortico-striatal drive: an in-silico study

Author(s): Ilaria Carannante; Martina Scolamiero; J. J. Johannes Hjorth; Alexander Kozlov; Bo Bekkouche; Lihao Guo; Arvind Kumar; Wojciech Chachólski; Jeanette Hellgren Kotaleski
Published in: Network Neuroscience, 2023, ISSN 2472-1751
Publisher: MIT Press Direct
DOI: 10.1162/NETN_A_00394

Homeodynamic feedback inhibition control in whole-brain simulations

Author(s): Jan Stasinski; Halgurd Taher; Jil Mona Meier; Michael Schirner; Dionysios Perdikis; Petra Ritter
Published in: PLOS Computational Biology, 2024, ISSN 1553-7358
Publisher: PLOS Computational Biology
DOI: 10.1371/JOURNAL.PCBI.1012595

Frontiers in Computational Neuroscience

Author(s): Federico Tesler; Roberta Maria Lorenzi; Adam Ponzi; Claudia Casellato; Claudia Casellato; Fulvia Palesi; Daniela Gandolfi; Claudia A. M. Gandini Wheeler Kingshott; Claudia A. M. Gandini Wheeler Kingshott; Claudia A. M. Gandini Wheeler Kingshott; Jonathan Mapelli; Egidio D'Angelo; Michele Migliore; Alain Destexhe
Published in: Frontiers in Computational Neuroscience, 2024, ISSN 1662-5188
Publisher: Frontiers Research Foundation
DOI: 10.3389/FNCOM.2024.1432593

Inference on the Macroscopic Dynamics of Spiking Neurons

Author(s): Nina Baldy, Martin Breyton, Marmaduke M. Woodman, Viktor K. Jirsa, Meysam Hashemi
Published in: Neural Computation, 2024, ISSN 0899-7667
Publisher: MIT Press
DOI: 10.1162/NECO_A_01701

Inference on the Macroscopic Dynamics of Spiking Neurons

Author(s): Nina Baldy, Martin Breyton, Marmaduke M. Woodman, Viktor K. Jirsa, Meysam Hashemi
Published in: Neural Computation, 2024, ISSN 0899-7667
Publisher: MIT Press
DOI: 10.1162/NECO_A_01701

Entropy and Complexity Tools Across Scales in Neuroscience: A Review

Author(s): Rodrigo Cofré, Alain Destexhe
Published in: Entropy, Issue 27, 2025, ISSN 1099-4300
Publisher: MDPI AG
DOI: 10.3390/E27020115

Modeling impairment of ionic regulation with extended Adaptive Exponential integrate-and-fire models

Author(s): Damien Depannemaecker; Federico Tesler; Mathieu Desroches; Viktor Jirsa; Alain Destexhe
Published in: Journal of Computational Neuroscience, 2024, ISSN 1573-6873
Publisher: Springer Nature
DOI: 10.1007/S10827-025-00893-7

The virtual multiple sclerosis patient

Author(s): Sorrentino, P.; Pathak, A.; Ziaeemehr, A.; Troisi Lopez, E.; Cipriano, L.; Romano, A.; Sparaco, M.; Quarantelli, M.; Banerjee, A.; Sorrentino, G.; Jirsa, V.; Hashemi, M.
Published in: iScience, 2024, ISSN 2589-0042
Publisher: Cell Press Elsevier Inc.
DOI: 10.1016/j.isci.2024.110101

Virtual epilepsy patient cohort: generation and evaluation

Author(s): Borana Dollomaja; Huifang E. Wang; Maxime Guye; Julia Makhalova; Fabrice Bartolomei; Viktor K. Jirsa
Published in: PLOS Computational Biology, 2024, ISSN 1553-7358
Publisher: PLOS
DOI: 10.1371/JOURNAL.PCBI.1012911

Symmetry breaking organizes the brain’s resting state manifold

Author(s): Jan Fousek, Giovanni Rabuffo, Kashyap Gudibanda, Hiba Sheheitli, Spase Petkoski, Viktor Jirsa
Published in: Scientific Reports, Issue 14, 2024, ISSN 2045-2322
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41598-024-83542-W

White matter changes after Gamma Knife Capsulotomy in patients with intractable obsessive-compulsive disorder

Author(s): Giorgio Spatola; Paul Triebkorn; Raphaelle Richieri; Christelle Baunez; Jean Farisse; Axelle Cretol; Eric Guedj; Viktor Jirsa; Jean Regis
Published in: Heliyon, 2024, ISSN 2405-8440
Publisher: Cell Press
DOI: 10.1016/J.HELIYON.2024.E34699

Mapping Brain Lesions to Conduction Delays: The Next Step for Personalized Brain Models in Multiple Sclerosis

Author(s): C. Mazzara, A. Ziaeemehr, E. Troisi Lopez, L. Cipriano, M. Angiolelli, M. Sparaco, M. Quarantelli, C. Granata, G. Sorrentino, M. Hashemi, V. Jirsa, P. Sorrentino
Published in: Human Brain Mapping, Issue 46, 2025, ISSN 1065-9471
Publisher: Wiley
DOI: 10.1002/HBM.70219

A computational approach to evaluate how molecular mechanisms impact large-scale brain activity

Author(s): Alain Destexhe; Maria Sacha; Federico Tesler; Rodrigo Cofre
Published in: Nature Computational Science, 2024, ISSN 2662-8457
Publisher: Springer Nature
DOI: 10.1038/S43588-025-00796-8

A lesion‐aware automated processing framework for clinical stroke magnetic resonance imaging

Author(s): Patrik Bey; Kiret Dhindsa; Amrit Kashyap; Michael Schirner; Jan Feldheim; Marlene Bönstrup; Robert Schulz; Bastian Cheng; Götz Thomalla; Christian Gerloff; Petra Ritter
Published in: Human Brain Mapping, 2024, ISSN 1097-0193
Publisher: Wiley Periodicals, LLC
DOI: 10.1002/HBM.26701

Virtual brain twins: from basic neuroscience to clinical use

Author(s): Wang, Huifang; Triebkorn, Paul; Breyton, Martin; Dollomaja, Borana; Lemarechal, Jean-Didier; Petkoski, Spase; Sorrentino, Pierpaolo; Depannemaecker, Damien; Hashemi, Meysam; Jirsa, Viktor
Published in: National Science Review, 2024, ISSN 2267-828X
Publisher: HAL
DOI: 10.1093/nsr/nwae079

A Multi-Scale Study of Thalamic State-Dependent Responsiveness

Author(s): Jorin Overwiening; Federico Tesler; Domenico Guarino; Alain Destexhe
Published in: PLOS Computational Biology, 2024, ISSN 1553-7358
Publisher: PLOS
DOI: 10.1101/2023.12.02.567941

Region-specific mean field models enhance simulations of local and global brain dynamics

Author(s): Roberta Maria Lorenzi, Fulvia Palesi, Claudia Casellato, Claudia A. M. Gandini Wheeler-Kingshott, Egidio D’Angelo
Published in: npj Systems Biology and Applications, Issue 11, 2025, ISSN 2056-7189
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41540-025-00543-9