Virtual Brain Twin for personalised treatment of Psychiatric Disorders

Informazioni relative al progetto

VIRTUAL BRAIN TWIN

ID dell’accordo di sovvenzione: 101137289

DOI

10.3030/101137289

Data della firma CE 22 Novembre 2023

Data di avvio 1 Gennaio 2024

Data di completamento 31 Dicembre 2027

Finanziato da

• Health

Costo totale

€ 10 000 000,00

Contributo UE

€ 10 000 000,00

Coordinato da

EBRAINS
Belgium

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (1)

Project website

Establishment of a website to disseminate the activities and results of the Virtual Brain Twin Project.

Other (2)

Integrative workflows GUI – first version

Front end integrative application, with multiscale graphic tools exposed uniformly

Virtual Brain Twin software ecosystem toolset – Backend first version

The 5 deliverables for WP6 are all working towards the same end-product (a Virtual Brain Twin software ecosystem) intended to be modular (with 2 larger components: front-end and backend) and developed in an agile manner. The Back-end offers an integrating solution for wrapping multiple tools under one reusable deployment solution.

Documents, reports (3)

Report on workflows

Report for workflows bridging from the molecular to cellular/microcircuit and to point neuron levels

Initial DCE Plan

Plan for dissemination and exploitation including communication activities

Project Launch

In-person consortium meeting to kick-off the project and agree operational plans.

Pubblicazioni

Peer reviewed articles (27)

Entropy and Complexity Tools Across Scales in Neuroscience: A Review

Autori: Rodrigo Cofré, Alain Destexhe
Pubblicato in: Entropy, Numero 27, 2025, ISSN 1099-4300
Editore: MDPI AG
DOI: 10.3390/E27020115

Would you publish unrealistic model?

Autori: Damien Depannemaecker
Pubblicato in: Biological Cybernetics, 2024, ISSN 1432-0770
Editore: Springer Nature
DOI: 10.1007/S00422-024-00999-8

Sharing brain imaging data in the Open Science era: how and why?

Autori: Giehl, Kathrin; Mutsaerts, Henk-Jan; Aarts, Kristien; Barkhof, Frederik; Caspers, Svenja; Chetelat, Gaël; Colin, Marie-Elisabeth; Düzel, Emrah; Frisoni, Giovanni B; Ikram, M Arfan; Jovicich, Jorge; Morbelli, Silvia; Oertel, Wolfgang; Paret, Christian; Perani, Daniela; Ritter, Petra; Segura, Bàrbara; Wisse, Laura E M; De Witte, Elke; Cappa, Stefano F; van Eimeren, Thilo
Pubblicato in: The Lancet Digital Health, 2024, ISSN 2589-7500
Editore: Elsevier
DOI: 10.34734/FZJ-2024-04789

Nature Communications

Autori: Dominik P. Koller; Michael Schirner; Petra Ritter
Pubblicato in: Nature Communications, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-47860-x

Simulation-based inference on virtual brain models of disorders

Autori: Meysam Hashemi; Abolfazl Ziaeemehr; Marmaduke M Woodman; Jan Fousek; Spase Petkoski; Viktor K Jirsa
Pubblicato in: Machine Learning: Science and Technology, 2024, ISSN 2632-2153
Editore: IOP
DOI: 10.1088/2632-2153/AD6230

Frontiers in Cellular Neuroscience

Autori: Pawan Faris; Doris Pischedda; Fulvia Palesi; Egidio D’Angelo; Egidio D’Angelo
Pubblicato in: Frontiers in Cellular Neuroscience, 2024, ISSN 1662-5102
Editore: Frontiers Media
DOI: 10.3389/fncel.2024.1386583

Mapping global brain reconfigurations following local targeted manipulations

Autori: Giovanni Rabuffo; Houefa-Armelle Lokossou; Zengmin Li; Abolfazl Ziaee-Mehr; Meysam Hashemi; Pascale P. Quilichini; Antoine Ghestem; Ouafae Arab; Monique Esclapez; Parul Verma; Ashish Raj; Alessandro Gozzi; Pierpaolo Sorrentino; Kai-Hsiang Chuang; Teodora-Adriana Perles-Barbacaru; Angèle Viola; Viktor K. Jirsa; Christophe Bernard
Pubblicato in: Proceedings of the National Academy of Sciences, 2025, ISSN 1091-6490
Editore: National Academy of Sciences
DOI: 10.1073/PNAS.2405706122

Simulating the impact of white matter connectivity on processing time scales using brain network models

Autori: Triebkorn, Paul; Jirsa, Viktor; Dominey, Peter
Pubblicato in: Communications Biology, 2025, ISSN 2399-3642
Editore: Springer Nature
DOI: 10.1038/S42003-025-07587-X

The Virtual Parkinsonian Patient

Autori: Marianna Angiolelli; Damien Depannemaecker; Hasnae Agouram; Jean Ŕegis; Romain Carron; Marmaduke Woodman; Letizia Chiodo; Paul Triebkorn; Abolfazl Ziaeemehr; Meysam Hashemi; Alexandre Eusebio; Viktor Jirsa; Pierpaolo Sorrentino
Pubblicato in: npj Systems Biology and Applications, 2025, ISSN 2056-7189
Editore: Springer Nature
DOI: 10.1038/S41540-025-00516-Y

Frontiers in Neuroanatomy

Autori: Ivan Velasco; Juan J. Garcia-Cantero; Juan J. Garcia-Cantero; Juan P. Brito; Juan P. Brito; Sofia Bayona; Sofia Bayona; Luis Pastor; Luis Pastor; Susana Mata; Susana Mata
Pubblicato in: Frontiers in Neuroanatomy, 2024, ISSN 1662-5129
Editore: Frontiers Media
DOI: 10.3389/fnana.2024.1342762

The impact of Parkinson’s disease on striatal network connectivity and cortico-striatal drive: an in-silico study

Autori: Ilaria Carannante; Martina Scolamiero; J. J. Johannes Hjorth; Alexander Kozlov; Bo Bekkouche; Lihao Guo; Arvind Kumar; Wojciech Chachólski; Jeanette Hellgren Kotaleski
Pubblicato in: Network Neuroscience, 2023, ISSN 2472-1751
Editore: MIT Press Direct
DOI: 10.1162/NETN_A_00394

Homeodynamic feedback inhibition control in whole-brain simulations

Autori: Jan Stasinski; Halgurd Taher; Jil Mona Meier; Michael Schirner; Dionysios Perdikis; Petra Ritter
Pubblicato in: PLOS Computational Biology, 2024, ISSN 1553-7358
Editore: PLOS Computational Biology
DOI: 10.1371/JOURNAL.PCBI.1012595

Frontiers in Computational Neuroscience

Autori: Federico Tesler; Roberta Maria Lorenzi; Adam Ponzi; Claudia Casellato; Claudia Casellato; Fulvia Palesi; Daniela Gandolfi; Claudia A. M. Gandini Wheeler Kingshott; Claudia A. M. Gandini Wheeler Kingshott; Claudia A. M. Gandini Wheeler Kingshott; Jonathan Mapelli; Egidio D'Angelo; Michele Migliore; Alain Destexhe
Pubblicato in: Frontiers in Computational Neuroscience, 2024, ISSN 1662-5188
Editore: Frontiers Research Foundation
DOI: 10.3389/FNCOM.2024.1432593

Inference on the Macroscopic Dynamics of Spiking Neurons

Autori: Nina Baldy, Martin Breyton, Marmaduke M. Woodman, Viktor K. Jirsa, Meysam Hashemi
Pubblicato in: Neural Computation, 2024, ISSN 0899-7667
Editore: MIT Press
DOI: 10.1162/NECO_A_01701

Inference on the Macroscopic Dynamics of Spiking Neurons

Autori: Nina Baldy, Martin Breyton, Marmaduke M. Woodman, Viktor K. Jirsa, Meysam Hashemi
Pubblicato in: Neural Computation, 2024, ISSN 0899-7667
Editore: MIT Press
DOI: 10.1162/NECO_A_01701

Entropy and Complexity Tools Across Scales in Neuroscience: A Review

Autori: Rodrigo Cofré, Alain Destexhe
Pubblicato in: Entropy, Numero 27, 2025, ISSN 1099-4300
Editore: MDPI AG
DOI: 10.3390/E27020115

Modeling impairment of ionic regulation with extended Adaptive Exponential integrate-and-fire models

Autori: Damien Depannemaecker; Federico Tesler; Mathieu Desroches; Viktor Jirsa; Alain Destexhe
Pubblicato in: Journal of Computational Neuroscience, 2024, ISSN 1573-6873
Editore: Springer Nature
DOI: 10.1007/S10827-025-00893-7

The virtual multiple sclerosis patient

Autori: Sorrentino, P.; Pathak, A.; Ziaeemehr, A.; Troisi Lopez, E.; Cipriano, L.; Romano, A.; Sparaco, M.; Quarantelli, M.; Banerjee, A.; Sorrentino, G.; Jirsa, V.; Hashemi, M.
Pubblicato in: iScience, 2024, ISSN 2589-0042
Editore: Cell Press Elsevier Inc.
DOI: 10.1016/j.isci.2024.110101

Virtual epilepsy patient cohort: generation and evaluation

Autori: Borana Dollomaja; Huifang E. Wang; Maxime Guye; Julia Makhalova; Fabrice Bartolomei; Viktor K. Jirsa
Pubblicato in: PLOS Computational Biology, 2024, ISSN 1553-7358
Editore: PLOS
DOI: 10.1371/JOURNAL.PCBI.1012911

Symmetry breaking organizes the brain’s resting state manifold

Autori: Jan Fousek, Giovanni Rabuffo, Kashyap Gudibanda, Hiba Sheheitli, Spase Petkoski, Viktor Jirsa
Pubblicato in: Scientific Reports, Numero 14, 2024, ISSN 2045-2322
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41598-024-83542-W

White matter changes after Gamma Knife Capsulotomy in patients with intractable obsessive-compulsive disorder

Autori: Giorgio Spatola; Paul Triebkorn; Raphaelle Richieri; Christelle Baunez; Jean Farisse; Axelle Cretol; Eric Guedj; Viktor Jirsa; Jean Regis
Pubblicato in: Heliyon, 2024, ISSN 2405-8440
Editore: Cell Press
DOI: 10.1016/J.HELIYON.2024.E34699

Mapping Brain Lesions to Conduction Delays: The Next Step for Personalized Brain Models in Multiple Sclerosis

Autori: C. Mazzara, A. Ziaeemehr, E. Troisi Lopez, L. Cipriano, M. Angiolelli, M. Sparaco, M. Quarantelli, C. Granata, G. Sorrentino, M. Hashemi, V. Jirsa, P. Sorrentino
Pubblicato in: Human Brain Mapping, Numero 46, 2025, ISSN 1065-9471
Editore: Wiley
DOI: 10.1002/HBM.70219

A computational approach to evaluate how molecular mechanisms impact large-scale brain activity

Autori: Alain Destexhe; Maria Sacha; Federico Tesler; Rodrigo Cofre
Pubblicato in: Nature Computational Science, 2024, ISSN 2662-8457
Editore: Springer Nature
DOI: 10.1038/S43588-025-00796-8

A lesion‐aware automated processing framework for clinical stroke magnetic resonance imaging

Autori: Patrik Bey; Kiret Dhindsa; Amrit Kashyap; Michael Schirner; Jan Feldheim; Marlene Bönstrup; Robert Schulz; Bastian Cheng; Götz Thomalla; Christian Gerloff; Petra Ritter
Pubblicato in: Human Brain Mapping, 2024, ISSN 1097-0193
Editore: Wiley Periodicals, LLC
DOI: 10.1002/HBM.26701

Virtual brain twins: from basic neuroscience to clinical use

Autori: Wang, Huifang; Triebkorn, Paul; Breyton, Martin; Dollomaja, Borana; Lemarechal, Jean-Didier; Petkoski, Spase; Sorrentino, Pierpaolo; Depannemaecker, Damien; Hashemi, Meysam; Jirsa, Viktor
Pubblicato in: National Science Review, 2024, ISSN 2267-828X
Editore: HAL
DOI: 10.1093/nsr/nwae079

A Multi-Scale Study of Thalamic State-Dependent Responsiveness

Autori: Jorin Overwiening; Federico Tesler; Domenico Guarino; Alain Destexhe
Pubblicato in: PLOS Computational Biology, 2024, ISSN 1553-7358
Editore: PLOS
DOI: 10.1101/2023.12.02.567941

Region-specific mean field models enhance simulations of local and global brain dynamics

Autori: Roberta Maria Lorenzi, Fulvia Palesi, Claudia Casellato, Claudia A. M. Gandini Wheeler-Kingshott, Egidio D’Angelo
Pubblicato in: npj Systems Biology and Applications, Numero 11, 2025, ISSN 2056-7189
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41540-025-00543-9