Objective Relieving serious health-related suffering for patients in palliative and end-of-life care, be it physical, psychological, social, or spiritual, is a global ethical responsibility. However, the profound psycho-emotional and existential distress entailed by such suffering, despite often being an enormous burden for both patients and their loved ones, remains a field largely overlooked by health care providers and the scientific community. Those people may develop mood or anxiety disorder for which neither non-pharmacological nor pharmacological interventions exist. In this context, we believe it is now time to target these unmet needs in the palliative care population. We want to initiate a paradigm shift at the boundaries between palliative care, psychiatry, psychology, neuroscience, and spiritual care. Our starting point is the preliminary results being reported for administration of psilocybin, the main psychoactive compound of so-called ‘psychedelic mushrooms’, in patients with depression. The objective of our project is thus to examine the clinical effect of a cutting-edge, individualised and patient-centred, open and standardised Psilocybin Therapy, addressing these unmet needs of patients in palliative care. We will show high quality evidence via a multi-centre Randomised Clinical Trial of the value of our therapeutic model in patients (and for the following four conditions: COPD, Atypical Parkinsonian Disorders, ALS, and Multiple Sclerosis), their loved ones and care providers, in a diverse sample of the European population, in addition to better understand the mechanisms of therapeutic change of our model. Finally, our project will establish a sustainable, multi-disciplinary, ecosystem of key European stakeholders jointly contributing to the medical use of psychedelic research and innovation, paving the way towards an ethical and cost-effective deployment of such a new line of care for patients in European palliative care service providers. Fields of science natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicineneurologymultiple sclerosissocial sciencespsychologynatural sciencesbiological sciencesecologyecosystemsmedical and health sciencesclinical medicinepsychiatryanxiety disorders Keywords Mental Health Depression Anxiety Randomized Controlled Trial Psilocybin Programme(s) HORIZON.2.1 - Health Main Programme HORIZON.2.1.3 - Non-Communicable and Rare Diseases Topic(s) HORIZON-HLTH-2023-DISEASE-03-01 - Novel approaches for palliative and end-of-life care for non-cancer patients Call for proposal HORIZON-HLTH-2023-DISEASE-03 See other projects for this call Funding Scheme HORIZON-RIA - HORIZON Research and Innovation Actions Coordinator ACADEMISCH ZIEKENHUIS GRONINGEN Net EU contribution € 1 753 913,75 Address HANZEPLEIN 1 9713 GZ Groningen Netherlands See on map Region Noord-Nederland Groningen Overig Groningen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 753 913,75 Participants (18) Sort alphabetically Sort by Net EU contribution Expand all Collapse all HK LABS AB Sweden Net EU contribution € 683 925,25 Address STORSKIFTESVAGEN 30 75647 Uppsala See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Östra Sverige Östra Mellansverige Uppsala län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 683 925,25 KOBENHAVNS UNIVERSITET Denmark Net EU contribution € 804 797,50 Address NORREGADE 10 1165 Kobenhavn See on map Region Danmark Hovedstaden Byen København Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 804 797,50 A+ SCIENCE AB Sweden Net EU contribution € 328 089,00 Address LUNTMAKARGATAN 22 111 37 Stockholm See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Östra Sverige Stockholm Stockholms län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 328 089,00 STICHTING OPEN: ONDERZOEK NAAR DE PSYCHEDELISCHE ERVARING NEDERLAND Netherlands Net EU contribution € 160 375,00 Address SINDERENSTRAAT 6 1107TN AMSTERDAM See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 160 375,00 UNIVERSIDAD DE NAVARRA Spain Net EU contribution € 240 250,00 Address CAMPUS UNIVERSITARIO EDIFICIO CENTRAL 31080 Pamplona See on map Region Noreste Comunidad Foral de Navarra Navarra Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 240 250,00 UPPSALA UNIVERSITET Sweden Net EU contribution € 150 000,00 Address VON KRAEMERS ALLE 4 751 05 Uppsala See on map Region Östra Sverige Östra Mellansverige Uppsala län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 150 000,00 FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD Portugal Net EU contribution € 506 737,50 Address AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD 1400-038 Lisboa See on map Region Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 506 737,50 STOCKHOLMS UNIVERSITET Sweden Net EU contribution € 57 500,00 Address UNIVERSITETSVAGEN 10 10691 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 57 500,00 RIJKSUNIVERSITEIT GRONINGEN Netherlands Net EU contribution € 300 013,75 Address Broerstraat 5 9712CP Groningen See on map Region Noord-Nederland Groningen Overig Groningen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 300 013,75 NARODNI USTAV DUSEVNIHO ZDRAVI Czechia Net EU contribution € 550 311,25 Address TOPOLOVA 748 250 67 Klecany See on map Region Česko Střední Čechy Středočeský kraj Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 550 311,25 EUROPEAN ASSOCIATION FOR PALLIATIVE CARE Belgium Net EU contribution € 141 950,00 Address AIRPORTLAAN 10 1800 Vilvoorde See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Halle-Vilvoorde Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 141 950,00 CENTRE EXPERT EN TECHNOLOGIES ET SERVICES POUR LE MAINTIEN EN AUTONOMIE A DOMICILE DES PERSONNES AGEES France Net EU contribution € 197 500,00 Address RUE GUSTAVE EIFFEL 2 10430 Rosiere Pres Troyes See on map Region Grand Est Champagne-Ardenne Aube Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 197 500,00 REGION HOVEDSTADEN Denmark Net EU contribution € 250 000,00 Address KONGENS VAENGE 2 3400 Hillerod See on map Region Danmark Hovedstaden Nordsjælland Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 250 000,00 EUROPEAN FEDERATION OF NEUROLOGICAL ASSOCIATIONS Belgium Net EU contribution € 80 000,00 Address RUE D' EGMONT 11 1000 BRUSSELS See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 80 000,00 STIFTELSEN 29K FOUNDATION Sweden Net EU contribution € 161 268,75 Address BIRGER JARLSGATAN 57 C 114 32 STOCKHOLM See on map Region Östra Sverige Stockholm Stockholms län Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 161 268,75 LONG ALLIANTIE NEDERLAND Netherlands Net EU contribution € 35 000,00 Address STATIONSPLEIN 125 3818 LE AMERSFOORT See on map Region West-Nederland Utrecht Utrecht Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 35 000,00 ASSOCIATION EUROPEENNE DE PSYCHIATRIE France Net EU contribution € 99 275,00 Address AVENUE DE LA LIBERTE 15 67000 Strasbourg See on map Region Grand Est Alsace Bas-Rhin Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 99 275,09 STIFTELSEN NORRSKEN MIND Sweden Net EU contribution € 46 250,00 Address C O SEB STIFTELSER KG 5 106 40 STOCKHOLM See on map Region Östra Sverige Stockholm Stockholms län Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 46 250,00
