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Psilocybin Therapy for Psychological Distress in Palliative Care Patients

Descrizione del progetto

Affrontare le dimensioni trascurate delle cure palliative

Alleviare le gravi sofferenze legate alla salute dei pazienti nelle cure palliative e di fine vita è una responsabilità etica che comprende dimensioni fisiche, psicologiche, sociali e spirituali. Ciononostante, gli operatori sanitari e la comunità scientifica spesso trascurano questo aspetto della cura. I pazienti e i loro cari devono affrontare disturbi dell’umore e dell’ansia senza che siano disponibili interventi efficaci. In quest’ottica, il progetto PsyPal, finanziato dall’UE, si basa sulle sperimentazioni condotte con la psilocibina per sviluppare una terapia con psilocibina personalizzata. Attraverso uno studio clinico randomizzato multicentrico, mira ad alleviare le sofferenze dei pazienti affetti da BPCO, disturbi parkinsoniani atipici, SLA e sclerosi multipla. Questo approccio integra psichiatria, psicologia, neuroscienze e cure spirituali, promuovendo un ecosistema multidisciplinare sostenibile per far progredire la ricerca psichedelica etica ed economica nelle cure palliative in Europa.

Obiettivo

Relieving serious health-related suffering for patients in palliative and end-of-life care, be it physical, psychological, social, or spiritual, is a global ethical responsibility. However, the profound psycho-emotional and existential distress entailed by such suffering, despite often being an enormous burden for both patients and their loved ones, remains a field largely overlooked by health care providers and the scientific community. Those people may develop mood or anxiety disorder for which neither non-pharmacological nor pharmacological interventions exist. In this context, we believe it is now time to target these unmet needs in the palliative care population. We want to initiate a paradigm shift at the boundaries between palliative care, psychiatry, psychology, neuroscience, and spiritual care. Our starting point is the preliminary results being reported for administration of psilocybin, the main psychoactive compound of so-called ‘psychedelic mushrooms’, in patients with depression. The objective of our project is thus to examine the clinical effect of a cutting-edge, individualised and patient-centred, open and standardised Psilocybin Therapy, addressing these unmet needs of patients in palliative care. We will show high quality evidence via a multi-centre Randomised Clinical Trial of the value of our therapeutic model in patients (and for the following four conditions: COPD, Atypical Parkinsonian Disorders, ALS, and Multiple Sclerosis), their loved ones and care providers, in a diverse sample of the European population, in addition to better understand the mechanisms of therapeutic change of our model. Finally, our project will establish a sustainable, multi-disciplinary, ecosystem of key European stakeholders jointly contributing to the medical use of psychedelic research and innovation, paving the way towards an ethical and cost-effective deployment of such a new line of care for patients in European palliative care service providers.

Campo scientifico (EuroSciVoc)

CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP. Cfr.: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

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Meccanismo di finanziamento

HORIZON-RIA -

Coordinatore

ACADEMISCH ZIEKENHUIS GRONINGEN
Contributo netto dell'UE
€ 1 753 913,75
Costo totale
€ 1 753 913,75

Partecipanti (19)