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Real-time biomarker detection systems for rapid medical decision-making in cancer and cardiac diseases

Project description

Next-gen diagnostics for rapid, real-time care

Doctors often face critical challenges in detecting life-threatening conditions like cancer and cardiac diseases quickly and accurately. Traditional diagnostic methods can be slow, require specialised laboratories, and may not provide real-time insights in urgent care settings. Patients in surgery rooms, ICUs, and even their homes need faster, more efficient solutions to improve treatment outcomes. The demand for compact, reliable, and intelligent diagnostic tools has never been greater. The EU-funded RealCare project will develop next-generation point-of-care (PoC) systems. Using cutting-edge biosensors, AI-driven analytics, and extended reality interfaces, RealCare enables real-time biomarker detection in human biofluids. Designed for clinical precision, portability, and interoperability, these systems promise to revolutionise patient monitoring and medical decision-making worldwide.

Objective

RealCare is a cutting-edge research initiative focused on developing and validating next-generation point-of-care (PoC) systems that detect essential biomarkers in human biofluids in real-time. These systems are designed to be compact, energy-efficient, and integrated with extended reality interfaces, with a specific emphasis on cancer and cardiac diseases in demanding clinical settings. RealCare's approach includes advanced biomarker detection technologies, such as microfluidics and new generations of microneedles, label-free electrochemical biosensors using 2D materials, optical sensors utilizing CRISPR, biological amplifiers combined with fluorescent microscopy, and scalable SPR with energy-efficient electronic readouts, AI data processing, and wireless communication units. Additionally, RealCare will design portable, interoperable, and adaptable PoC systems that integrate the biomarker detection technology with vital sign monitoring, including advanced data analytics and AI methods. The initiative also focuses on developing intuitive extended reality interfaces, such as augmented and virtual reality, to visualize biomarker data in real-time and facilitate rapid medical decision-making in integrated in-care environments and workflows. Rigorous clinical validation studies will be conducted in relevant clinical settings, including the surgery room, ICU, and patient's home, to ensure accuracy, reliability, usability, and impact on patient outcomes.
RealCare places special attention on including a diverse patient population in their studies to validate the effectiveness of the developed systems. Data quality, interoperability, and medical data protection are key considerations in RealCare's strategy. Based on our unique PoC technological platform and our strong, multidisciplinary consortium partnership, we propose promising lab-to-market paths with the potential for significant societal impact.

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Keywords

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Programme(s)

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Topic(s)

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Funding Scheme

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HORIZON-IA - HORIZON Innovation Actions

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) HORIZON-HLTH-2023-TOOL-05

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Coordinator

UNIVERSITEIT TWENTE
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 1 660 675,00
Address
DRIENERLOLAAN 5
7522 NB Enschede
Netherlands

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Region
Oost-Nederland Overijssel Twente
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 1 660 675,00

Participants (8)

Partners (2)

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