Objective
Molecules are chiral if they exist in two forms, called enantiomers, which behave like image and mirror image. In many applications, e.g. in medicine, nutrition, and crop protection, chiral molecules are required as a single enantiomer (enantiomerically pure compound) but not as a mixture (racemate). The market for enantiomerically pure compounds exceeds 100 billion annually and continues to grow rapidly. Despite significant recent advances in asymmetric catalysis, many chiral compounds are for cost reasons prepared as racemates and separated thereafter. If only one enantiomer is required, the other enantiomer remains as waste. The aim of the CALIDE project is to provide for the first time a comprehensive set of methods for the quantitative conversion of racemates into single enantiomers employing exclusively light and a photocatalyst. The process includes the light-induced formation of short-lived achiral intermediates which decay to the starting materials on a thermal reaction channel. By employing two intrinsically different channels for formation and decay, the transformation overcomes issues of microscopic reversibility which render related thermal deracemization reactions impossible. The photocatalyst interacts with the racemic substrates and enables the destruction and reformation of the stereogenic element. A first objective (work package I) is to identify suitable binding motifs to achieve the required proximity in the energy transfer step for compounds displaying an axis or plane of chirality. The second objective (work package II) aims at a deracemization of compounds with a stereogenic carbon center via a reversible cleavage of carbon-carbon or carbon-heteroatom bonds. The bond cleavage can be initiated by energy or electron transfer. The third objective (work package III) tackles substrates with a carbon-hydrogen bond at the stereogenic carbon atom. Bond fission by hydrogen abstraction from the catalyst is proposed as the key feature of this method.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences catalysis photocatalysis
- medical and health sciences health sciences nutrition
- agricultural sciences agriculture, forestry, and fisheries agriculture
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2023-ADG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80333 Muenchen
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.