Project description
A clean brain is a healthy brain
Cerebrospinal fluid and interstitial fluid in the brain play a crucial role in maintaining brain homeostasis, nutrient delivery and waste clearance. Impaired fluid dynamics are associated with conditions such as Alzheimer's disease, suggesting that waste must be cleared during sleep or otherwise accumulates and contributes to disease progression. Therefore, advanced tools are required to fully understand and manipulate brain fluid dynamics for clinical benefits. The ERC-funded aCleanBrain project aims to investigate new fluid dynamics mechanisms and develop novel mathematical tools for brain simulations. Project findings have important implications for neurological health and for understanding and treating neurological disorders.
Objective
"Scientific breakthroughs in neuroscience explain the need for sleep and the development of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases in terms of fluid dynamics: the waste created during the day is cleared away as we sleep or it accumulates. However, a decade of research after the original theory was posed has revealed that the underlying physical mechanisms are still not understood and that the advanced mathematical tools are needed.
In this project we propose a research program addressing 1) new fluid dynamics mechanisms, 2) novel numerical analysis for advanced multi-physics brain simulations, and 3) a framework for patient-specific simulations. We will exploit reduced order and machine learning methods in addition to finite element solutions. With
successful delivery, the ""aCleanBrain"" will establish the main drivers of brain fluid dynamics, provide a foundation for accurate, efficient and robust algorithms for multi-physics problems and develop a software framework for advanced biomechanical brain simulations."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences computer and information sciences software
- medical and health sciences basic medicine neurology dementia alzheimer
- medical and health sciences basic medicine neurology parkinson
- natural sciences computer and information sciences computational science multiphysics
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2023-ADG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
0164 OSLO
Norway
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.