Brain fluids - Transport and clearance

Project Information

aCleanBrain

Grant agreement ID: 101141807

DOI

10.3030/101141807

EC signature date 12 July 2024

Start date 1 August 2024

End date 31 July 2029

Funded under

• European Research Council (ERC)

Total cost

€ 2 493 750,00

EU contribution

€ 2 493 750,00

Coordinated by

SIMULA RESEARCH LABORATORY AS
Norway

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data Management Plan (1)

Data Management Plan

Publications

Peer reviewed articles (12)

Multiphasic transport in the human cranial dura: how meningeal lymphatic vessels drive waste clearance from brain cerebrospinal fluid

Author(s): Alberto Girelli, Andreas Solheim, Sofie Lysholm Lian, Tryggve Holck Storås, Kaja Nordengen, Kent-Andre Mardal
Published in: Fluids and Barriers of the CNS, 2026, ISSN 2045-8118
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S12987-026-00861-Y

The impact of human brain geometry on the transport of an intrathecal tracer

Author(s): Andreas Solheim, Geir Ringstad, Per Kristian Eide, Lars Magnus Valnes, Kent-Andre Mardal
Published in: Fluids and Barriers of the CNS, Issue 23, 2026, ISSN 2045-8118
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S12987-026-00764-Y

Stretch and flow at the gliovascular interface: High-fidelity modeling of astrocyte endfeet

Author(s): Marius Causemann, Rune Enger, Marie E. Rognes
Published in: Proceedings of the National Academy of Sciences, Issue 123, 2026, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/PNAS.2517059123

Modeling glioma-induced impairments on the glymphatic system

Author(s): Alexandre Poulain, Jørgen Riseth, Kyrre E. Emblem, Kent-Andre Mardal
Published in: Fluids and Barriers of the CNS, Issue 23, 2026, ISSN 2045-8118
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S12987-025-00736-8

<scp>T2</scp> ‐Weighted <scp>T1</scp> Mapping and Automated Segmentation of <scp>CSF</scp> : Assessment of Solute Gradients in the Healthy Brain

Author(s): Tryggve Holck Storås, Sofie Lysholm Lian, Ingrid Mossige, Jørgen Riseth, Siri Fløgstad Svensson, Grethe Løvland, Geir Ringstad, Kent‐André Mardal, Kyrre Eeg Emblem, Kaja Nordengen
Published in: Journal of Magnetic Resonance Imaging, Issue 64, 2026, ISSN 1053-1807
Publisher: Wiley
DOI: 10.1002/JMRI.70169

On the prospects of interpolatory spline bases for accurate mass lumping strategies in isogeometric analysis

Author(s): Yannis Voet, Espen Sande
Published in: Computer Methods in Applied Mechanics and Engineering, Issue 452, 2026, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.1016/J.CMA.2026.118762

Parameter-Robust Preconditioner for Stokes-Darcy Coupled Problem with Lagrange Multiplier

Author(s): Xiaozhe Hu, Miroslav Kuchta, Kent-Andre Mardal, Xue Wang
Published in: SIAM Journal on Scientific Computing, Issue 48, 2026, ISSN 1064-8275
Publisher: Society for Industrial & Applied Mathematics (SIAM)
DOI: 10.1137/25M1744393

Parameter-Robust Preconditioners for a Four-Field Thermo-Poroelasticity Model

Author(s): Mingchao Cai, Miroslav Kuchta, Jingzhi Li, Ziliang Li, Kent-Andre Mardal
Published in: SIAM Journal on Scientific Computing, Issue 48, 2026, ISSN 1064-8275
Publisher: Society for Industrial & Applied Mathematics (SIAM)
DOI: 10.1137/25M1726923

Parameter-Robust Preconditioners for a Cell-by-Cell Poroelasticity Model with Interface Coupling

Author(s): Marius Causemann, Miroslav Kuchta
Published in: SIAM Journal on Scientific Computing, Issue 48, 2026, ISSN 1064-8275
Publisher: Society for Industrial & Applied Mathematics (SIAM)
DOI: 10.1137/25M1770151

Estimation of fluid flow velocities in cortical brain tissue driven by the microvasculature

Author(s): Timo Koch, Kent-André Mardal
Published in: Interface Focus, Issue 15, 2025, ISSN 2042-8901
Publisher: The Royal Society
DOI: 10.1098/RSFS.2024.0042

In-silico solute transport via perivascular networks in the human intracranial space

Author(s): Marius Causemann, Miroslav Kuchta, Rami Masri, Marie E. Rognes
Published in: Nature Communications, 2026, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-77174-Z

A cut finite element method for the Biot system of poroelasticity

Author(s): Nanna Berre, Kent-Andre Mardal, André Massing, Ivan Yotov
Published in: Computer Methods in Applied Mechanics and Engineering, Issue 458, 2026, ISSN 0045-7825
Publisher: Elsevier BV
DOI: 10.1016/J.CMA.2026.119048

Book chapters (6)

Computing for Life: Modeling and Simulation of Electrodiffusion in Dense Reconstructions of Cerebral Tissue

Author(s): Halvor Herlyng, Marius Causemann, Gaute T. Einevoll, Ada J. Ellingsrud, Geir Halnes, Marie E. Rognes
Published in: Lecture Notes in Computational Science and Engineering, Numerical Analysis and Scientific Computing: an Anthology, 2026
Publisher: Springer Nature Switzerland
DOI: 10.1007/978-3-032-33428-2_14

Quantifying cerebrospinal fluid tracer concentration in the brain

Author(s): Bastian Zapf, Lars Magnus Valnes, Kent-Andre Mardal, & Ludmil Zikatanov
Publisher: Springer

Estimating molecular transport parameters using inverse PDE models

Author(s): Bastian Zapf, Marius Zeinhofer, Kent-Andre Mardal
Published in: Simula SpringerBriefs on Computing, Mathematical Modelling of the Human Brain II, 2025
Publisher: Springer Nature Switzerland
DOI: 10.1007/978-3-032-00679-0_7

Meshing the intracranial compartments: The cerebellum, cerebrum, brainstem, and cerebrospinal fluid

Author(s): Lars Magnus Valnes, & Kent-Andre Mardal
Published in: Meshing the intracranial compartments: The cerebellum, cerebrum, brainstem, and cerebrospinal fluid
Publisher: Springer Cham
DOI: 10.1007/978-3-0

Two-compartment modeling of tracer transport in the brain

Author(s): Jørgen N. Riseth, Timo Koch, Kent-Andre Mardal
Published in: Simula SpringerBriefs on Computing, Mathematical Modelling of the Human Brain II, 2025
Publisher: Springer Nature Switzerland
DOI: 10.1007/978-3-032-00679-0_8

Signal increase ratio prediction with CNNs

Author(s): Marius Zeinhofer, Kent-Andre Mardal
Published in: Simula SpringerBriefs on Computing, Mathematical Modelling of the Human Brain II, 2025
Publisher: Springer Nature Switzerland
DOI: 10.1007/978-3-032-00679-0_6