Skip to main content
Go to the home page of the European Commission (opens in new window)
English English
CORDIS - EU research results
CORDIS

Deciphering the role of regulatory factors driving epigenetic inheritance of alternative chromatin states

Objective

Epigenetics, the study of molecules and mechanisms that perpetuate alternative gene activity states in the context of the same DNA sequence, is an exciting field with important epistemological and biomedical implications, but the molecular mechanisms underlying epigenetic inheritance are still little understood. Polycomb group proteins are pleiotropic chromatin components that have been suggested to be capable of driving epigenetic inheritance and their dysregulation leads to cell fate changes and is associated with cancer. Recently, we discovered that a transient decrease in expression of a Polycomb gene can drive the formation of tumors of epigenetic nature, i.e. in the absence of DNA mutations. The goal of WaddingtonMemory is to decipher how epigenetic components can lead to stable changes in cell fate. Specifically, we will:

Aim 1: Identify the molecular steps leading to epigenetic cell fate derailment following transient Polycomb protein depletion in Drosophila. We will perform a time-course study using bulk and single-cell multiomic and imaging approaches in order to dissect the dynamics of cell fate transformation.
Aim 2: Identify the Polycomb-targets leading to cell fate dysregulation and decipher their mechanistic role. We will test candidate factors identified in Aim 1 in order to identify those that drive cell fate derailment and to elucidate their mode of action.
Aim 3: Test the role of epigenetic inheritance in mammalian cell differentiation. We will analyse the role of epigenetic inheritance in mouse gastruloids, an in vitro system that reflects cell differentiation events typically found in early embryogenesis.

Together, this groundbreaking project will reveal how epigenetic components drive cell fate derailment and it will establish robust paradigms that can be utilized by the scientific community to discriminate between epigenetic inheritance and DNA sequence-mediated cell transformation.lli

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

You need to log in or register to use this function

Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

HORIZON-ERC - HORIZON ERC Grants

See all projects funded under this funding scheme

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) ERC-2023-ADG

See all projects funded under this call

Host institution

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 2 499 764,00
Address
RUE MICHEL ANGE 3
75794 PARIS
France

See on map

Region
Ile-de-France Ile-de-France Hauts-de-Seine
Activity type
Research Organisations
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 2 499 764,00

Beneficiaries (1)

My booklet 0 0