Project description
The role of primary cilia in disease
Primary cilia are microtubule-based organelles that sense nutrient availability and influence metabolism. Their dysfunction can lead to genetic disorders known as ciliopathies. Recent studies have revealed that primary cilia communicate with mitochondria to drive metabolic changes during nutrient stress, particularly when glutamine (Q) is used as a critical carbon source. With this in mind, the ERC-funded QtCilia project aims to investigate why mammalian cells rely on a sensory monocilium to perceive their environment and how this communication occurs with mitochondria. Focusing on renal epithelia affected by ciliopathies, the project will explore the mechanisms of nutrient response and the role of primary cilia in mitochondrial communication. Ultimately, it seeks to enhance the understanding of fundamental biological processes and their implications for disease.
Objective
Primary cilia are single, microtubule-based, organelles protruding as antennae at the surface of most cells. Their dysfunction is associated with several genetic disorders, called the ciliopathies.
We recently identified a new, previously undescribed, role for primary cilia as sensors of cellular nutrient availability. In this novel mTORC1-independent pathway, cilia directly communicate with mitochondria to drive metabolic reprogramming under nutrient stress, when glutamine (Q) becomes an obligated carbon source.
Here, we will tackle two fundamental questions: i. why mammalian cells “taste” the extracellular milieu via a sensory monocilium, and how is the resulting information conveyed to mitochondria? ii. what are the consequences when the cross-communication is impaired?
While our newly identified cilia pathway is relevant in multiple cell types, here we focus on renal epithelia, because the kidney is severely affected in the ciliopathies and because we contributed defining the crucial role of metabolic balancing in this organ. The goals are: 1) to identify the precise mechanism(s) underlying the ciliary response to nutrients; 2) to test the hypothesis that primary cilia directly cross-communicate with mitochondria via protein exchange; 3) to define the relevance of this pathway for the pathogenesis and treatment of ciliopathies.
We will use newly developed methods and combine high-throughput with hypothesis-driven approaches in a broad program designed to balance high-risk/high-gain with low-risk/high-gain tasks. The project has two inherent souls: one devoted to the understanding of a novel, very basic biological process; the second to the translation of novel basic concepts to decipher disease pathophysiology.
QtCilia (Q tasting Cilia) benefits from a unique across-disciplines background and expertise of the PI, who positions herself strategically to make paradigm-changing discoveries, for which exceptional resources via innovative funding schemes are sought.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine physiology pathophysiology
- natural sciences biological sciences biochemistry biomolecules proteins
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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HORIZON.1.1 - European Research Council (ERC)
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(opens in new window) ERC-2023-ADG
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20132 Milano
Italy
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