Project description
Transforming the field of C-H functionalisation
Current methods of organic synthesis are essential for creating new drugs, agrochemicals and sustainable materials. However, the process of C-H functionalisation, which modifies carbon-hydrogen bonds, faces challenges. Most approaches rely on directing groups attached to the substrate, limiting the scope of reactions. Additionally, some methods depend on costly and rare metal catalysts. In this context, the ERC-funded C-HANCE project aims to overcome these limitations by introducing a new concept: charge control. This approach steers C-H bond reactivity without the need for directing groups, opening up new possibilities for reactions. With this breakthrough, C-HANCE could transform the field and produce valuable compounds for a wide range of uses.
Objective
Organic synthesis stands as the beating heart of technological and societal advancement, driving breakthroughs in drug discovery, agrochemistry, materials design, and the pursuit of a more sustainable world. In a world where C–H bonds are the main functional groups available, the field of C–H functionalisation has experienced exponential growth over the past two decades. While state-of-the-art methods have led to remarkable achievements, they remain confined by the dominance of substrate-controlled reactions driven by directing group logic, and by being largely reliant on precious metal catalysts.
C-HANCE proposes to open a new page in C–H functionalisation, exploiting the emerging concept of charge control as a mode to influence and steer reactivity of C–H bonds. This will usher in a new logic for C–H bond functionalisation, where reagent control can address substrates devoid of directing groups and where entirely novel reactions will emerge. This will not only reshape our fundamental understanding of C–H functionalisation, but also yield valuable products for downstream applications. Given my unique expertise and documented track-record of achievements – especially in the exploration of out-of-the-box, non-mainstream fields of synthetic chemistry –, I am in a unique position to lead in the unfolding of this new era.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2023-ADG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1010 WIEN
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.