Project description
Transforming the field of C-H functionalisation
Current methods of organic synthesis are essential for creating new drugs, agrochemicals and sustainable materials. However, the process of C-H functionalisation, which modifies carbon-hydrogen bonds, faces challenges. Most approaches rely on directing groups attached to the substrate, limiting the scope of reactions. Additionally, some methods depend on costly and rare metal catalysts. In this context, the ERC-funded C-HANCE project aims to overcome these limitations by introducing a new concept: charge control. This approach steers C-H bond reactivity without the need for directing groups, opening up new possibilities for reactions. With this breakthrough, C-HANCE could transform the field and produce valuable compounds for a wide range of uses.
Objective
Organic synthesis stands as the beating heart of technological and societal advancement, driving breakthroughs in drug discovery, agrochemistry, materials design, and the pursuit of a more sustainable world. In a world where C–H bonds are the main functional groups available, the field of C–H functionalisation has experienced exponential growth over the past two decades. While state-of-the-art methods have led to remarkable achievements, they remain confined by the dominance of substrate-controlled reactions driven by directing group logic, and by being largely reliant on precious metal catalysts.
C-HANCE proposes to open a new page in C–H functionalisation, exploiting the emerging concept of charge control as a mode to influence and steer reactivity of C–H bonds. This will usher in a new logic for C–H bond functionalisation, where reagent control can address substrates devoid of directing groups and where entirely novel reactions will emerge. This will not only reshape our fundamental understanding of C–H functionalisation, but also yield valuable products for downstream applications. Given my unique expertise and documented track-record of achievements – especially in the exploration of out-of-the-box, non-mainstream fields of synthetic chemistry –, I am in a unique position to lead in the unfolding of this new era.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
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Programme(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Topic(s)
Funding Scheme
HORIZON-ERC - HORIZON ERC GrantsHost institution
1010 Wien
Austria