Project description
Tackling osteoarthritis with innovative immunotherapy
Osteoarthritis, a debilitating joint disease affecting over 250 million people globally, is a major cause of disability and strains healthcare systems, consuming nearly 0.5 % of GDP. Addressing this challenge, the EIC-funded Anti-IL-6 project, spearheaded by Peptinov, is developing a groundbreaking immunotherapy. Their approach targets the pro-inflammatory protein IL-6, which drives cartilage destruction. By using a vaccine-like method, Peptinov’s treatment prompts the patient’s immune system to produce antibodies against IL-6, halting disease progression. Notably, this therapy costs only 5-10 % of conventional options by using cost-effective, immunogenic peptides. Promising results from Phase I trials on patients support the project’s advancement to Phase II trials, bringing the therapy closer to market readiness.
Objective
Osteoarthritis is a debilitating disease affecting the joint and a leading cause of disability worldwide. It affects at least 250m people and incurs healthcare costs of toward 0.5% of the GDP.
Peptinov is developing an active immunotherapy that can halt inflammation-driven destruction of the cartilage in the joints. We use a unique approach to neutralise a key pro-inflammatory protein (IL-6) driving chronic inflammation. Our vaccine-like approach stimulates the patients own immune system to produce antibodies against excess IL-6 and neutralise its biological function. By doing so we will halt disease progression.
Our treatment will cost 5-10% of conventional immunotherapies as we inject patients with inexpensive, immunogenic peptides to stimulate production of endogenous antibodies. Phase I clinical trial yielded very encouraging preliminary safety and tolerability data on 24 patients. This project will implement the Phase II clinical trial and make our therapy out-licensing ready.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology immunotherapy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-EIC-ACC-BF - HORIZON EIC Accelerator Blended Finance
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2023-ACCELERATOR-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75009 PARIS
France
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.