Project description
Bone-on-chip technology for osteoporosis-driven bone loss
Osteoporosis leads to fragile bones and a higher risk of fractures. Traditional methods such as animal testing fall short in accurately replicating the human bone environment, especially for studying bone loss caused by the disease. Organ-on-chip technology has emerged as a promising solution to animal testing, but current models lack the ability to represent exacerbated bone degradation. With the support of the Marie Skłodowska-Curie Actions programme, the ReModel-OP project plans to develop a cutting-edge bone-on-chip model with integrated sensors to track bone loss biomarkers. ReModel-OP will combine techniques from microfabrication, tissue engineering, molecular biology and electrochemistry to design tools that can track bone loss and work in models that mimic real bones.
Objective
Osteoporosis is a common skeletal disorder characterized by imbalanced bone remodeling, where osteoclast activity is exacerbated leading to increased bone degradation and fracture risk. The socio-economic burden of this disease is elevated in the EU and is expected to further increase in coming years, highlighting the need of improved disease models and drug screening platforms in pre-clinical research. Organ-on-chip (OoC) technology has been demonstrating high potential to replace anima testing in drug screening and pathophysiological modeling, but current output measurements in OoC applications are still mostly limited to end-point assays or require large volume of sample. In addition, bone OoC models competent for exacerbated bone resorption, the main consequence of osteoporosis, are still lacking, indicating a need for improved and more representative models.
To address this issue, in this project I aim to identify and validate potential strategies to reduce osteoporosis-driven bone loss, through the establishment of a bone-on-chip model with integrated sensors for online detection of bone degradation biomarkers. I will combine knowledge from disciplines ranging from microfabrication, tissue engineering, molecular biology, imaging and electrochemistry to fabricate osteoclast resorption biomarker sensors and integrate them in OoC models that faithfully replicate the bone microenvironment. My experience in osteoclast biology will be integrated with the extensive expertise of the Brigham and Women´s Hospital - Harvard Medical School in tissue engineering, microfabrication and materials science for the successful implementation of this proposal. These experiences will provide the optimal training environment not only to become a leader in organ-on-chip disease modelling but also to position myself advantageously to succeed in non-academic sectors.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences electrochemistry
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
- engineering and technology other engineering and technologies microtechnology organ on a chip
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
7522 NB Enschede
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.