Objective
Stem cells and organoids have revolutionized our ability to build tissues and organ-like structures ‘in a dish’. Organoid models of a wide range of human tissues are increasingly applied to drug and treatment development and to fundamental and translational studies. However, the challenge of simultaneously growing more than one different tissues in a single functional organoid remains. Human neuromuscular organoids (NMOs) represent a landmark discovery toward building more complex and physiologically relevant human tissues in vitro. NMOs closely capture the cellular repertoire and structural and functional properties of the neuromuscular system, but, similar to other organoids, they do not reach adult tissue stages of maturation, at least in part, due to lack of connectivity and in vivo-like sensory inputs, including bioelectrical cues, essential in physiological phenomena. In a multi-disciplinary approach, the eNeuroMus project aims to test the hypothesis that delivery of brain-like input, currently excluded from NMO models, will enhance the complexity and maturation status of NMOs toward adult tissue stages. To this end, NMOs will be interfaced with conformable multielectrode arrays, based on organic conducting polymers, to expose NMOs to brain-like input via electrical stimulation and to record NMO electrophysiological activity in a growth stage-dependent manner. To decipher the effects of electrical stimulation on tissue maturation, electrophysiology assays will be combined with cutting-edge technologies, including spatial transcriptomics, optogenetics and advanced imaging. This analysis pipeline will result in a rich dataset, unravelling the long-term effects of electrical stimulation and the molecular pathways involved in the maturation of human neuromuscular organoids. Overall, the eNeuroMus project will deliver a novel and sophisticated framework for engineering the next generation of biohybrid organoids as tools for modelling human development and disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences polymer sciences
- medical and health sciences medical biotechnology cells technologies stem cells
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
13125 Berlin
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.