Objective
Separating the two enantiomeric versions of a chiral molecule is crucial for ensuring the safety of pharmacological drugs and agrochemicals for the human body and the environment. However, the enantiomeric separation process at industrial level through chiral chromatography is costly and slow. As a result, 90% of chiral pharmaceutical drugs and agrochemicals are being sold as racemic mixtures.
The PiEs-on-chip project aims at exploiting enantio-selective optical forces produced in silicon-based Photonic Integrated Circuits (PICs) to separate enantiomers. The chiral light-matter interaction, between the light guided throughout the PIC and the enantiomers results in a momentum transfer due to optical forces that move the particles of opposite chirality in opposite directions, leading to their Photo-induced Enantiomeric Separation (PiES). The PIC would be easy to mass-produce at low cost per device, thus, making optical enantiomeric separation more viable at industry level.
Guided modes along integrated rectangular waveguides demonstrated inherent transversal and/or longitudinal spin which generates chiral optical forces that could be used for separating chiral particles in the transversal and/or longitudinal direction. Although the use of silicon-based waveguides is promising, they still lack more strength in the optical forces that can exert on smaller particles like molecules, partially due to the simple designs of the tested PICs. This requires new strategies to enhance enantio-selective interactions.
The PiES-on-chip novel approach consists in inversely designing the PIC with topology optimization with the objective of maximizing the produced enantio-selective optical forces. Next, we will fabricate the optimized PIC and measure the generated chiral optical forces with Photo-induced Force Microscopy. Finally, we will deliver the chiral particles over the PIC with a microfluidic layer and experimentally verify the laser-driven enantiomeric-separation on chip.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences mathematics pure mathematics topology
- natural sciences physical sciences optics microscopy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
46022 VALENCIA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.