Project description
New paths in radical chemistry
Aliphatic molecules are essential in many chemical processes, but creating them can be difficult due to the behaviour of alkyl radicals. These radicals are typically nucleophilic, meaning they do not react well with electron-rich compounds such as aromatics and olefins. On the other hand, electrophilic radicals do react strongly with these compounds, but are not widely useful in synthetic chemistry. Supported by the Marie Skłodowska-Curie Actions programme, the BRAT project will develop a new method to reverse the behaviour of these radicals. By combining photoredox catalysis with boryl radical-mediated H-atom transfer, the project will generate new radicals that can react with electron-rich compounds. This will facilitate the creation of high-value aliphatic products and expand the possibilities of radical chemistry.
Objective
"Aliphatic molecules are integral to every aspect of chemistry and radical chemistry has strong impact in their preparation. However, radical reactions are heavily influenced by the polarity of these species, which ultimately controls their reactivty profile.Most notably, standard alkyl radicals are nucleophilic and therefore do not react with electron rich aromatics and olefins. Electrophilic radicals display strong reactivity with these species but they are of limited synthetic value.
This project seeks to address this challenge by developing an innovative approach for radical ""umpolung"". In particular, we will demonstrate the integration of photoredox catalysis and boryl radical-mediated H-atom transfer catalysis, as a unique blueprint for the activation of alpha,alpha-diborylated alkalnes. This will generate alpha,alpha-diborylated radicals that, owing to their strong electrophilic character, will (i) react with electron rich aromatics and olefins and then (ii) enable diverge functionalization. In this way we will overcome the fundamental issue that nucleophilic alkyl radicals do not react with electron rich olefins/aromatics. This reactivity will streamline the preparation of many high-value but difficult to make aliphatic products, will be used in late-stage functionalizations and will substantially expand the fields of photoredox catalysis and boryl radical chemistry.
This research capitalizes on recent developments of the Leonori group that has experience in the design of methodologies based on both H-atom transfer and boryl radical reactivity.
The completion of such an innovative and ambitious project at RWTH Aachen University will be facilitated by generating, transferring, sharing and disseminating knowledge, and will enhance my future career following the training plan envisioned.
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Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
52062 Aachen
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.