Project description
Understanding the long arm of childhood
Children from low-income households face lifelong health disparities, a phenomenon known as the ‘long arm of childhood’. This complex issue arises because the effects of early socioeconomic disadvantage often only become apparent in adulthood, making it challenging for researchers to track and address these impacts. With the support of the Marie Skłodowska-Curie Actions programme, the EpiSoDi project will use DNA-methylation (DNAm) as a ‘molecular wormhole’ to connect early-life socioeconomic conditions with health outcomes later in life. This study will integrate methylation profile scores into a trial assessing the effects of cash transfers on early childhood health, while also examining the associations of these profiles with adult health.
Objective
Children who grow up in low-income homes are at risk for worse mental and physical health for their entire lives, a phenomenon known as the “long arm of childhood”. But, understanding and intervening on this process is enormously difficult, as the effects of childhood environments can take decades to become visible in adult morbidity and mortality. What researchers need is a “wormhole”, i.e. a passage through time that connects childhood and adulthood. In the proposed research project, I will examine the utility of DNA-methylation (DNAm) as a “molecular wormhole” for investigating how socioeconomic disadvantage in childhood is linked with (mental)health across the lifespan. The proposed “Epigenetic pathways of Socioeconomic Disparities across the lifespan” (EpiSoDi) project allows me to conduct my independent research project with leading scientists at the Max Planck Institute in Berlin. Building on the Baby’s First Years Study (N=850), I will, for the first time, integrate methylation profile scores (MPS) into a randomized controlled trial testing whether unconditional cash transfers to low-income mothers for the first 4 years of the child’s life cause changes in the child’s methylome in early childhood. Additionally, I will travel forward through the wormhole, by developing MPSs that index the socioeconomic conditions of childhood, and testing their associations with mental and physical health in older adulthood (Health and Retirement Study, N= 4,018). This will generate important and novel insights in the way social inequality shape differential outcomes in (mental) health across the lifespan. Throughout my research, I have sought to bridge social and genetic science to better understand child development. The project fits this aspiration and is an indispensable step in my career as it allows me to extend my current academic pursuits, further grow into an independent researcher and help me to specialize in the exciting field of epigenetics.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- natural sciences physical sciences astronomy planetary sciences celestial mechanics
- natural sciences biological sciences genetics epigenetics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.