Project description
Understanding microbial interactions affecting plant health
Plants depend on microbes for their growth and health. The EU aims to replace 50 % of pesticides with biological solutions by 2030. Research into plant-microbe interactions seeks to develop tailored microbial communities to protect crops and reduce pesticide use, using CRISPR-Cas-derived genetic tools to better understand these interactions. Supported by the Marie Skłodowska-Curie Actions programme, the SEEDITING project aims to adapt reverse genetics tools, originally developed for synthetic bacterial communities, to native seed microbiota. The project will develop an efficient microbiome editing tool for synthetic communities and apply it to natural seed microbiota to observe its effects on microbiome dynamics and microbial interactions. It will also evaluate the impact of seed microbiota editing on transmission rates to seedlings and the resulting plant phenotypes.
Objective
Over 80% of human food relies on plants, but up to 40% of crops are lost to pests and diseases. Chemical pesticides have boosted yields but pose health and environmental risks. To address this, the EU aims to replace 50% of pesticides with biological solutions by 2030. As a result of hundreds of millions years of coevolution, plants host a diverse microbiota coming from soil, offering biotechnological potential. Exploring plant-microbe and microbe-microbe interactions can revolutionize agriculture, enhancing food security. The discovered plant-beneficial microbial interactions could be used to generate tailored microbial communities, capable of protecting plants and reducing the need for pesticides. CRISPR-Cas derived genetic tools to edit the plant seed microbiome in order to decipher the main microbial interactions affecting plant health. SEEDITING aims to adapt these tools, analogous to reverse genetics, from simplified synthetic bacterial communities to native seed microbiota. The main outcomes of the SEEDITING project will be to master an efficient tool for microbiome editing on SynComs (WP1) and to deploy this editing tool on extracted seed natural microbiota (WP2) to observe the consequences of editing on microbiome dynamics and microbial interactions in vitro. Finally, I will assess the impact of seed microbiota editing on the microbial transmission rates to the seedlings and the resulting plant phenotypes (WP3). This project will lead to major breakthroughs in microbiome sciences and plant-microorganisms interactions in agriculture by generating three main outputs opening new research avenues: 1) Validation of a microbiome editing tool transferrable to multiple ecosystems to decipher microbial interactions in natural communities. 2) Identification of microorganisms responsible for the modulation of host phenotypes. 3) Identification of microbial functions responsible for the phenotypes or involved in host colonization and survival.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences evolutionary biology
- agricultural sciences agriculture, forestry, and fisheries agriculture
- natural sciences biological sciences microbiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75007 PARIS CEDEX 07
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.