Project description
Photocatalysis improves complex polyene reactions
Biosynthetic polyene cyclisation helps transform linear polyenes into complex, multi-ring structures through a series of chemical reactions. Organic chemists seek to emulate this process by developing synthetic methodologies based on these cascades. Research has shown that photoinduced electron transfer can achieve polyene cyclisations under mild conditions, as plants do in photosynthesis. Combining fluorinated alcohols (known for their strong H-bonding donor ability and low nucleophilicity) with PET processes creates a unique strategy for biomimetic polyene cyclisation. Funded under the Marie Skłodowska-Curie Actions programme, the PhotoCage project aims to design supramolecular cage photocatalysts that enhance these reactions. Researchers will apply these photocatalysts to polyene cyclisations, study reaction mechanisms and develop an asymmetric version.
Objective
Biosynthetic polyene cycllization, where complex structures are obtained, represents an impressive example of Nature's a chemist. Organic chemists are trying to emulate the Nature to develop synthetic methodologies base on these cascades. It has been demonstrated that Photoinduced Electron Transfer (PET) can achieve this polyene cyclizations under milder conditions, as plants do during photosynthesis. In this context, fluorinated alcohols are very special solvents in organic chemistry due to their particular chemical and physical properties (e. g. strong H-bonding donor ability, low nucleophylicity). The combination of fluorinated alcohols with PET processes make this strategy unique for develop new biomimetic polyzene cyclization. To achieve PhotoCage 4 main research objectives should be implemented: (a) Design of the supramolecular cage photocatalyst and study of the interaction between them; (b) Application of the designed supramolecular cage - photocatalyst to polyene cyclizations; (c) Study of the reaction mechanims; (d) Impementation and development of an asymmetric version.
The proposal also offers me a unique opportunity to develop transferable skills thanks to the courses proposed by Saarland University and Professor T. Gulder wich will be a valuable asset for continuing my academic career.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural scienceschemical sciencescatalysisphotocatalysis
- natural scienceschemical sciencesorganic chemistryalcohols
- natural sciencesbiological sciencesbotany
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Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsCoordinator
66123 Saarbrucken
Germany