Project description
Advanced methods for modifying drug molecules
Late-stage functionalisation (LSF) is a method used to make small, specific changes to complex molecules, often near the end of their synthesis. In bioactive compounds, such as drugs, LSF enables the addition or modification of functional groups without altering the core structure. This is useful for fine-tuning the properties of a compound, saving time while improving its effectiveness or reducing side effects. With the support of the Marie Skłodowska-Curie Actions programme, the LateFun project aims to pioneer an LSF method for adding versatile functional groups to alkenes and 1,3-dienes, organic molecules with a unique structure that allows for diverse chemical reactions.
Objective
The late-stage functionalization (LSF) of bioactive compounds is currently a hot topic in the chemistry community, as it allows for the rapid and divergent construction of molecule complexity and avoids the need for time-consuming de novo synthesis. This is especially relevant in the fields of drug discovery and medicinal chemistry where the fast identification of structure-activity relationships is crucial. Especially intriguing in this context are alkenes and 1,3-dienes, as they are frequently occurring motifs in natural products and drug molecules including important antibiotics and antivirals. However, methods for the introduction of a broad variety of functional groups via the LSF of these moieties remain underdeveloped. LateFun aims to create new chemical space by developing a first-in-class methodology for the incorporation of a highly versatile functional handle via the LSF of alkenes and 1,3-dienes, whose well-established subsequent transformations will allow for the rapid assembly of diverse structures. Applying this innovative protocol to the LSF of complex natural products and drug molecules will be of great importance and impact, going beyond the current state of art. The real-life applications of this cutting-edge research proposal will be explored during a secondment phase in Novartis (Basel), providing for valuable industry insights and interdisciplinary aspects. The host’s expertise in late-stage functionalization of bioactive molecules using catalytically generated carbyne equivalents perfectly complements the applicant’s strong background in photocatalysis and therefore guarantees two-way-transfer of knowledge between the host group and the ER (Experienced Researcher). The successful implementation of this action in the highly international and interdisciplinary environment of ICIQ and Novartis will enable the fellow to develop a unique research profile and will be crucial in building an independent academic career.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences chemical sciences catalysis photocatalysis
- medical and health sciences basic medicine medicinal chemistry
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antivirals
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
43007 TARRAGONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.