Project description
A new approach to cardiovascular imaging with advance MRI techniques
Cardiovascular diseases (CVDs) like heart attacks and strokes require precise diagnosis and treatment planning. Traditional 4D Flow MRI, while valuable, is limited by the trade-off between resolution, image quality and scan time. Current methods achieve only moderate resolution and take about 10 minutes per scan. With the support of the Marie Skłodowska-Curie Actions programme, the SBI-Cardio project aims to overcome these limitations using simulation-based imaging (SBI). By integrating computational fluid dynamics with low-resolution 4D Flow MRI data, SBI can generate high-resolution velocity fields. This novel method promises ultra-high-resolution images and faster scan times, revolutionising CVD diagnosis and treatment, leading to more accurate clinical decisions and improved patient outcomes.
Objective
The 3D, time-resolved blood flow measurement technique known as 4D Flow Magnetic Resonance Imaging (MRI) is highly valuable for research and can play a crucial role in cardiovascular disease (CVD) diagnosis and treatment planning. However, it is limited by the fundamental trade-off between resolution, image quality, and scan time since current 4D Flow MRI methods use compressed sensing or spatiotemporal acceleration to achieve only a spatial resolution of 1-3mm and temporal resolution of 25-100ms in a scan time of ~10 minutes. To overcome this challenge, simulation-based imaging (SBI) may provide a method to augment 4D flow MRI data by fitting computational fluid dynamics (CFD) simulation to low-resolution and noisy 4D Flow MRI data.
The primary objective of SBI is to generate a high-resolution velocity field by optimizing the simulation to closely match the available data. This approach overcomes the aforementioned limitations of 4D Flow MRI, which often suffers from inherent errors in resolution and scan time, leading to both quantitative and qualitative discrepancies. By utilizing SBI, a more precise and comprehensive visualization of blood flow can be achieved.
Therefore, the ultimate goal of this project is to develop a novel SBI method for MRI that will be used to address a wide range of cardiovascular (CVDs) such as heart attacks, strokes, and congenital heart defects; providing high-quality images of structure and function with ultra-high resolution and fast scan time. The long-term impact of the proposed SBI framework is expected to revolutionize clinical diagnosis and surgical decision-making leading to more effective treatments and improved outcomes for CVD patients.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3036 Lemesos
Cyprus
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.