Project description
A new path for colorectal cancer diagnostics
Colorectal cancer (CRC) is a leading cause of cancer-related deaths, highlighting the urgent need for improved diagnostic methods. Supported by the Marie Skłodowska-Curie Actions programme, the μQuantEV project seeks to address this challenge by developing a groundbreaking platform that uses extracellular vesicles as biomarkers for CRC. This initiative combines advanced microfluidic technology with sophisticated analytical methods to facilitate the rapid and cost-effective detection of CRC-specific EVs. The project features a microfluidic EV enrichment module for capturing CRC-associated EVs and a fluorescence-based detection system for real-time analysis. With a strong focus on translational research and collaboration with clinical partners, μQuantEV aims to transform CRC diagnostics and advance personalised medicine, offering non-invasive screening alternatives.
Objective
The μQuantEV project aims to revolutionize the landscape of colorectal cancer (CRC) diagnostics through the development of a groundbreaking Point-of-Care (PoC) platform. Leveraging the emerging potential of extracellular vesicles (EVs) as robust biomarkers for CRC, this interdisciplinary endeavor combines cutting-edge microfluidic technology with advanced analytical methods to enable the sensitive, rapid, and cost-effective detection of CRC-specific EVs.
By designing, fabricating, and characterizing a microfluidic EV enrichment module, the project pioneers an innovative approach for the selective capture of CRC-associated EVs from patient-derived samples. Simultaneously, a state-of-the-art fluorescence-based EV detection and quantification module is developed to provide accurate and real-time analysis of the captured EVs. These two modules are seamlessly integrated to create a Lab-on-a-Chip diagnostic platform capable of detecting CRC at early stages with exceptional sensitivity and specificity.
Furthermore, μQuantEV places a strong emphasis on translational research, collaborating closely with clinical partners to validate the platform's performance using patient samples. The project also incorporates extensive open science practices to foster collaboration, transparency, dissemination of research outcomes.
Upon successful completion, the μQuantEV platform holds the potential to revolutionize CRC diagnostics, offering a cost-effective, non-invasive, and efficient alternative to current screening methods. Beyond CRC, the technology developed in this project can pave the way for the application of EV-based diagnostics in various other diseases, driving advancements in personalized medicine and improving healthcare outcomes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology other engineering and technologies microtechnology lab on a chip
- natural sciences biological sciences cell biology
- medical and health sciences clinical medicine oncology colorectal cancer
- medical and health sciences health sciences personalized medicine
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
33003 OVIEDO
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.