Project description
Oral insulin diabetes treatment
Diabetes affects millions of people worldwide. While insulin injections are the standard treatment, they can hinder patient compliance. Oral insulin is preferred, but challenges in the gastrointestinal tract prevent its availability. Supported by the Marie Skłodowska-Curie Actions programme, the Micro-Insulin project will develop an oral insulin delivery system using microneedle technology. It will investigate the physicochemical properties, preliminary safety in in vitro and ex vivo models, as well as pharmacokinetics and efficacy in rodent models. The project aims for high insulin absorption through polymeric needle microcapsules, using a piercing mechanism for controlled and localised release, enhanced by a polymer matrix and cationic cyclodextrin polymer. It aligns with the EU’s Horizon 2020 Health, Demographic Change, and Well-being Programme.
Objective
Diabetes is a chronic metabolic syndrome with millions of people affected globally, caused by impaired glucose metabolism due to insufficient pancreatic insulin release or the development of insulin resistance. To control the glycaemic load in the diabetic patient, insulin needs to be administered by parenteral injection which causes patient compliance issues. Oral administration of insulin is the preferred route but there is no oral insulin on the market because of the hurdles it faces in the gastro-intestinal tract. Oral administration is the preferred route but until now there is no oral insulin in the market because of the hurdle (gastric pH and enzymatic degradation, low permeability) it faces in the gastrointestinal tract. Therefore, there is an unmet need for oral insulin development. To solve these problems, we will use microneedle technology for development of oral insulin delivery (Micro-Insulin). Oral administration of Micro-insulin will be investigated at the level of physicochemical characterization, preliminary safety assessment in in vitro and ex vivo models, and pharmacokinetics and efficacy in in vivo rodent models. High insulin intestinal absorption will be expected from the polymeric needle microcapsule via its piercing mechanism with controlled and localised release of insulin, which will be facilitated by a polymer matrix and the permeating-enhancing cationic cyclodextrin polymer. The objective of the project is aligned with the EUs Horizon 2020 Programme focus area - Health, Demographic Change and Wellbeing and UN Sustainable Development Goal - Good Health and Well-Being. The Global Marie Curie Fellowship research will be conducted in partnership with the outgoing phase at a renowned institution from a third countries and incoming phase at EU country. The team is well equipped with skill and infrastructure required for the project. This will help bring advanced skills to EU countries and will have a significant impact on the fellow's career.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine endocrinology diabetes
- natural sciences chemical sciences polymer sciences
- medical and health sciences basic medicine pharmacology and pharmacy pharmacokinetics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
4 DUBLIN
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.