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Microfluidic Platform for Analyzing Sperm Flagellar Beating in a Chemical Gradient

Project description

Computer vision to see how sperms move

The follicular fluid (FF) biochemical signals guide sperm through the egg complex. This fluid contains various substances, and more research is needed to fully understand how sperm move. Supported by the Marie Skłodowska-Curie Actions programme, the MicroBeaCh project aims to use biomimicry to study the coordinated beating of sperm cells during natural fertilisation. The project will investigate the fundamental aspects of sperm cell movement and will be the first to use computer vision and AI to analyse the natural beating patterns of sperm cells. Success in this project could lead to new parameters for selecting high-quality sperm for assisted reproduction, ultimately improving the success rates of these techniques.

Objective

MicroBeaCh aims to exploit the biomimetic approach to unravel harmonized spermatozoa beating that favors natural fertilization. Biochemical stimuli in follicular fluid (FF) are pivotal in guiding sperm cells for their traversal through the cumulus-oocyte complex. FF contains peptides, proteins, steroid hormones, polysaccharides, metabolites, antioxidants, and reactive oxygen species. Despite some preliminary investigations and the potential advantages afforded by microfluidics approaches, a noticeable dearth exists in the unraveling mechanism of spermatozoa beating. MicroBeaCh intends to explore the fundamental beating contributions in sperm cell migration. This will be the first study exploiting computer vision and artificial intelligence approaches to obtain the natural beating behaviors of sperm cells. We believe that the successful accomplishment of MicroBeaCh will establish the foundation of novel parameters for quality sperm selection in application to assisted reproduction, where identifying specific beating patterns will advance the outcomes of the practices.

Fields of science (EuroSciVoc)

Keywords

Programme(s)

Topic(s)

Funding Scheme

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Call for proposal

(opens in new window) HORIZON-MSCA-2023-PF-01

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Coordinator

BEEZ BIOTECH
Net EU contribution
€ 211 754,88
Address
6 RUE PIERRE JOSEPH COLIN LOCAUX C3
35000 RENNES
France
SME
Yes
Region
Bretagne Bretagne Ille-et-Vilaine
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Links
Total cost
No data