Project description
Novel image-guided system for neurosurgery
Neuronavigation systems are advanced medical tools used during neurosurgery to aid surgeons in precisely navigating and targeting areas within the brain. These systems integrate preoperative imaging, such as MRI or CT scans, with real-time information during surgery. Although they enhance surgical precision, they cannot account for brain deformation. Funded by the Marie Skłodowska-Curie Actions programme, the SafeREG project proposes to combine computational science and clinical expertise to develop a novel image registration method using intraoperative ultrasound. By focusing on the resection of brain tumours, the goal is to preserve patients’ cognitive function and improve surgical outcomes.
Objective
Brain tumors strike people in the prime of life. Surgical resection is the initial treatment for nearly all brain tumors and aims at maximizing the extent of tumor resection while preserving the patient's cognitive function. To optimize this tradeoff, neuronavigation systems have been developed to provide intraoperative guidance to surgeons. These systems allow for the visualization of the position of surgeons' surgical tools relative to the tumor and critical brain areas visible in preoperative Magnetic Resonance Imaging. However, these systems become inaccurate as the surgery progresses since they do not account for brain deformation and tissue resection occurring during surgery.
In an interdisciplinary effort, project SafeREG combines the researcher's background to the expertise of computational scientists from INRIA and clinicians from Parisian hospitals. Its objective is to invent a novel image registration methodology with intraoperative ultrasound that is rich enough to capture complex deformations occurring at the tumor and resection cavity boundaries, fast enough to be employable clinically, and interpretable enough for informed decision-making by neurosurgeons. This will be accomplished by pushing the envelope of scientific knowledge in (1) cross-modality domain adaptation for weakly- and unsupervised image segmentation; (2) modality-invariance representation learning using contrastive learning; (3) non-rigid registration with discrete probabilistic methods; (4) simulated-based variational inference for registration uncertainty quantification that leverages biomechanical knowledge. This research has the potential to deliver accurate and informed image-guided surgery, conferring a lower risk of new neurologic deficits and improved patient prognosis. Beyond neurosurgery, it has broad applications to additional areas of image-guided therapy, including spine, liver, and prostate surgery.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine surgery
- natural sciences physical sciences acoustics ultrasound
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
78153 Le Chesnay Cedex
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.